Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer

• Published in: Nature materials Vol. 5; no. 10; pp. 791 - 796
• Main Authors: Yang, Yi-Yan, Wang, Yong, Gao, Shujun, Ye, Wen-Hui, Yoon, Ho Sup
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2006; Nature Publishing Group
• Subjects: Absorbable Implants; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Biodegradation; Biomaterials; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cations; Cell Line, Tumor; Chemistry and Materials Science; Coated Materials, Biocompatible - chemistry; Condensed Matter Physics; Crystallization - methods; Cytotoxicity; Deoxyribonucleic acid; DNA; Drug Combinations; Drug Delivery Systems - methods; Drug therapy; Drugs; Gene expression; Humans; Interleukin-12 - administration & dosage; Interleukin-12 - chemistry; Interleukin-12 - genetics; letter; Materials Science; Medical research; Nanostructures - chemistry; Nanotechnology; Optical and Electronic Materials; Paclitaxel - administration & dosage; Paclitaxel - chemistry; Pharmaceutical Vehicles - chemistry; Plasmids - administration & dosage; Plasmids - genetics; Polymers - chemistry; Rodents; Transfection - methods

Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications. Co-delivery of drugs and DNA has been proposed to enhance gene expression or to achieve the synergistic/combined effect of dr...