Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer
Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications. Co-delivery of drugs and DNA has been proposed to enhance gene expression or to achieve the synergistic/combined effect of dr...
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| Published in | Nature materials Vol. 5; no. 10; pp. 791 - 796 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.10.2006
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications. Co-delivery of drugs and DNA has been proposed to enhance gene expression or to achieve the synergistic/combined effect of drug and gene therapies. Attempts have been made to deliver drugs and DNA simultaneously using liposomes. Here we report cationic core-shell nanoparticles that were self-assembled from a biodegradable amphiphilic copolymer. These nanoparticles offer advantages over liposomes, as they are easier to fabricate, and are more readily subject to modulation of their size and degree of positive charge. More importantly, they achieve high gene-transfection efficiency and the possibility of co-delivering drugs and genes to the same cells. Enhanced gene transfection with the co-delivery of paclitaxel has been demonstrated by in vitro and in vivo studies. In particular, the co-delivery of paclitaxel with an interleukin-12-encoded plasmid using these nanoparticles suppressed cancer growth more efficiently than the delivery of either paclitaxel or the plasmid in a 4T1 mouse breast cancer model. Moreover, the co-delivery of paclitaxel with Bcl-2-targeted small interfering RNA (siRNA) increased cytotoxicity in MDA-MB-231 human breast cancer cells. |
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| AbstractList | Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications
1
. Co-delivery of drugs and DNA has been proposed to enhance gene expression or to achieve the synergistic/combined effect of drug and gene therapies
2
,
3
,
4
,
5
,
6
. Attempts have been made to deliver drugs and DNA simultaneously using liposomes
7
. Here we report cationic core–shell nanoparticles that were self-assembled from a biodegradable amphiphilic copolymer. These nanoparticles offer advantages over liposomes, as they are easier to fabricate, and are more readily subject to modulation of their size and degree of positive charge. More importantly, they achieve high gene-transfection efficiency and the possibility of co-delivering drugs and genes to the same cells. Enhanced gene transfection with the co-delivery of paclitaxel has been demonstrated by
in vitro
and
in vivo
studies. In particular, the co-delivery of paclitaxel with an interleukin-12-encoded plasmid using these nanoparticles suppressed cancer growth more efficiently than the delivery of either paclitaxel or the plasmid in a 4T1 mouse breast cancer model. Moreover, the co-delivery of paclitaxel with Bcl-2-targeted small interfering RNA (siRNA) increased cytotoxicity in MDA-MB-231 human breast cancer cells. Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications. Co-delivery of drugs and DNA has been proposed to enhance gene expression or to achieve the synergistic/combined effect of drug and gene therapies. Attempts have been made to deliver drugs and DNA simultaneously using liposomes. Here we report cationic core-shell nanoparticles that were self-assembled from a biodegradable amphiphilic copolymer. These nanoparticles offer advantages over liposomes, as they are easier to fabricate, and are more readily subject to modulation of their size and degree of positive charge. More importantly, they achieve high gene-transfection efficiency and the possibility of co-delivering drugs and genes to the same cells. Enhanced gene transfection with the co-delivery of paclitaxel has been demonstrated by in vitro and innbsp;vivo studies. In particular, the co-delivery of paclitaxel with an interleukin-12-encoded plasmid using these nanoparticles suppressed cancer growth more efficiently than the delivery of either paclitaxel or the plasmid in a 4T1 mouse breast cancer model. Moreover, the co-delivery of paclitaxel with Bcl-2-targeted small interfering RNA (siRNA) increased cytotoxicity in MDA-MB-231 human breast cancer cells. [PUBLICATION ABSTRACT] Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited their applications. Co-delivery of drugs and DNA has been proposed to enhance gene expression or to achieve the synergistic/combined effect of drug and gene therapies. Attempts have been made to deliver drugs and DNA simultaneously using liposomes. Here we report cationic core-shell nanoparticles that were self-assembled from a biodegradable amphiphilic copolymer. These nanoparticles offer advantages over liposomes, as they are easier to fabricate, and are more readily subject to modulation of their size and degree of positive charge. More importantly, they achieve high gene-transfection efficiency and the possibility of co-delivering drugs and genes to the same cells. Enhanced gene transfection with the co-delivery of paclitaxel has been demonstrated by in vitro and in vivo studies. In particular, the co-delivery of paclitaxel with an interleukin-12-encoded plasmid using these nanoparticles suppressed cancer growth more efficiently than the delivery of either paclitaxel or the plasmid in a 4T1 mouse breast cancer model. Moreover, the co-delivery of paclitaxel with Bcl-2-targeted small interfering RNA (siRNA) increased cytotoxicity in MDA-MB-231 human breast cancer cells. |
| Author | Ye, Wen-Hui Yoon, Ho Sup Wang, Yong Yang, Yi-Yan Gao, Shujun |
| Author_xml | – sequence: 1 givenname: Yi-Yan surname: Yang fullname: Yang, Yi-Yan organization: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way – sequence: 2 givenname: Yong surname: Wang fullname: Wang, Yong organization: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way – sequence: 3 givenname: Shujun surname: Gao fullname: Gao, Shujun organization: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way – sequence: 4 givenname: Wen-Hui surname: Ye fullname: Ye, Wen-Hui organization: School of Biological Sciences, Nanyang Technological University – sequence: 5 givenname: Ho Sup surname: Yoon fullname: Yoon, Ho Sup organization: School of Biological Sciences, Nanyang Technological University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16998471$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Absorbable Implants Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Biodegradation Biomaterials Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cations Cell Line, Tumor Chemistry and Materials Science Coated Materials, Biocompatible - chemistry Condensed Matter Physics Crystallization - methods Cytotoxicity Deoxyribonucleic acid DNA Drug Combinations Drug Delivery Systems - methods Drug therapy Drugs Gene expression Humans Interleukin-12 - administration & dosage Interleukin-12 - chemistry Interleukin-12 - genetics letter Materials Science Medical research Nanostructures - chemistry Nanotechnology Optical and Electronic Materials Paclitaxel - administration & dosage Paclitaxel - chemistry Pharmaceutical Vehicles - chemistry Plasmids - administration & dosage Plasmids - genetics Polymers - chemistry Rodents Transfection - methods |
| Title | Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer |
| URI | http://dx.doi.org/10.1038/nmat1737 https://link.springer.com/article/10.1038/nmat1737 https://www.ncbi.nlm.nih.gov/pubmed/16998471 https://www.proquest.com/docview/222758954 https://search.proquest.com/docview/21247620 https://search.proquest.com/docview/35092902 https://search.proquest.com/docview/68915657 |
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