Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner

• Published in: Frontiers in immunology Vol. 13; p. 865386
• Main Authors: Quach, Huy Quang, Johnson, Christina, Ekholt, Karin, Islam, Rakibul, Mollnes, Tom Eirik, Nilsson, Per H
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media 04.04.2022; Frontiers Media S.A
• Subjects: acute inflammation; Biochemistry; Biokemi; Blood Platelets - metabolism; cytokines; Cytokines - metabolism; human whole blood; Humans; IL-8; Immunology; Interleukin-8 - metabolism; Leukocytes - metabolism; platelets; thrombin; Thrombin - metabolism; Thrombin - pharmacology; acute inflammation; human whole blood; cytokines; thrombin; IL-8; platelets

In a recent study, we found an elevated level of interleukin 8 (IL-8) in response to bacterial incubation in thrombin-sufficient human whole blood anticoagulated by the fibrin polymerization blocking peptide GPRP. Whether thrombin directly activated leukocytes or mediated the release thrombin-depend...