Quantifying individual differences in brain morphometry underlying symptom severity in Autism Spectrum Disorders

• Published in: Scientific reports Vol. 9; no. 1; pp. 9898 - 10
• Main Authors: Pua, Emmanuel Peng Kiat, Ball, Gareth, Adamson, Chris, Bowden, Stephen, Seal, Marc L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.07.2019; Nature Publishing Group
• Subjects: 59/57; 631/1647/245/1628; 692/699/476/1373; Adolescent; Adult; Anatomy; Autism; Autism Spectrum Disorder - pathology; Brain - pathology; Brain architecture; Brain Mapping - methods; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Cortex; Female; Humanities and Social Sciences; Humans; Image Processing, Computer-Assisted - methods; Individuality; Intelligence; Learning algorithms; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Morphometry; multidisciplinary; Nervous system; Neurobiology; Neurodevelopmental disorders; Neurosciences; Phenotypic variations; Science; Science (multidisciplinary); Severity of Illness Index; Young Adult

The neurobiology of heterogeneous neurodevelopmental disorders such as autism spectrum disorders (ASD) are still unclear. Despite extensive efforts, most findings are difficult to reproduce due to high levels of individual variance in phenotypic expression. To quantify individual differences in brai...