Engineered EVs from LncEEF1G - overexpressing MSCs promote fibrotic liver regeneration by upregulating HGF release from hepatic stellate cells

• Published in: Experimental & molecular medicine Vol. 57; no. 3; pp. 584 - 600
• Main Authors: Zhang, Jiebin, Qiu, Xiaotong, Lei, Yunguo, Chen, Haitian, Wu, Dongwei, Wang, Tingting, Sui, Xin, Xiao, Jiaqi, Jiang, Chenhao, Zhang, Huayao, Liu, Yasong, Liu, Xiaoquan, Zhang, Yingcai, Che, Xu, Lin, Ye, Yao, Jia, Pan, Zihao, Li, Rong, Zheng, Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2025; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 13; 13/100; 631/1647/350; 631/337/572; 631/532/2074; 64/60; Animals; Artificial intelligence; Biomedical and Life Sciences; Biomedicine; Carbon tetrachloride; Cell proliferation; Disease Models, Animal; Extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - metabolism; Fibrosis; Growth factors; Hepatectomy; Hepatic Stellate Cells - metabolism; Hepatocyte growth factor; Hepatocyte Growth Factor - genetics; Hepatocyte Growth Factor - metabolism; Hepatocytes; Humans; Liver cirrhosis; Liver Cirrhosis - genetics; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Cirrhosis - therapy; Liver diseases; Liver Regeneration - genetics; Male; Medical Biochemistry; Mesenchymal Stem Cells - metabolism; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular Medicine; Stellate cells; Stem Cells; Surgery; Up-Regulation; 생화학

Fibrosis is a disease that negatively affects liver regeneration, resulting in severe complications after liver surgery. However, there is still no clinically effective treatment for promoting fibrotic liver regeneration because the underlying hepatocellular mechanism remains poorly understood. Thro...