Short-term dietary restriction in old zebrafish changes cell senescence mechanisms

• Published in: Neuroscience Vol. 334; pp. 64 - 75
• Main Authors: Arslan-Ergul, Ayca, Erbaba, Begun, Karoglu, Elif Tugce, Halim, Dilara Ozge, Adams, Michelle M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 15.10.2016
• Subjects: aging; Aging - physiology; Animals; beta-Galactosidase - metabolism; Body Weight; brain; Brain - physiology; Caloric Restriction; cell proliferation; Cell Proliferation - physiology; Cellular Senescence - physiology; Cohort Studies; Danio rerio; dietary restriction; Neurology; Random Allocation; telomere; Telomere - metabolism; Time Factors; Zebrafish; cell proliferation; telomere; TRF; brain; DR; GFP; SA-β-gal; qPCR; aging; zebrafish; BrdU; gfap; dietary restriction; telomeric terminal restriction fragment; quantitative polymerase chain reaction; green fluorescent protein; bromodeoxyuridine; senescence associated β-galactosidase; glial fibrillary acidic protein

•Age but not short-term dietary restriction (DR) affects cell proliferation.•Short-term DR shortens telomere lengths in young subjects.•Impacts of DR may not always be beneficial for cellular senescence and organismal aging.•First study to systematically examine a short-term DR in zebrafish. Brain a...