The SarA protein family of Staphylococcus aureus
Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that S. aureus infections can now occur in other wise healthy individuals in the community setting. The success of this organism can be attributed to t...
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| Published in | The international journal of biochemistry & cell biology Vol. 40; no. 3; pp. 355 - 361 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.01.2008
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| Subjects | |
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| Abstract | Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that
S. aureus infections can now occur in other wise healthy individuals in the community setting. The success of this organism can be attributed to the large array of regulatory proteins, including the SarA protein family, used to respond to changing microenvironments. Sequence alignment and structural data reveal that the SarA protein family can be divided into three subfamilies: (1) single domain proteins; (2) double domain proteins; (3) MarR homologs. Structural studies have also demonstrated that SarA, SarR, SarS, MgrA and thus possibly all members of this protein family are winged helix proteins with minor variations. Mutagenesis studies of SarA disclose that the winged helix motifs are important for DNA binding and function. Recent progress concerning the functions and plausible mechanisms of regulation of SarA and its homologs are discussed. |
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| AbstractList | Staphylococcus aureus
is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that
S. aureus
infections can now occur in other wise healthy individuals in the community setting. The success of this organism can be attributed to the large array of regulatory proteins, including the SarA protein family, used to respond to changing microenvironments. Sequence alignment and structural data reveal that the SarA protein family can be divided into three subfamilies: 1) single domain proteins; 2) double domain proteins and 3) MarR homologs. Structural studies have also demonstrated that SarA, SarR, SarS, MgrA, and thus possibly all members of this protein family are winged helix proteins with minor variations. Mutagenesis studies of SarA disclose that the winged helix motifs are important for DNA binding and function. Recent progress concerning the functions and plausible mechanisms of regulation of SarA and its homologs are discussed. Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that S. aureus infections can now occur in other wise healthy individuals in the community setting. The success of this organism can be attributed to the large array of regulatory proteins, including the SarA protein family, used to respond to changing microenvironments. Sequence alignment and structural data reveal that the SarA protein family can be divided into three subfamilies: (1) single domain proteins; (2) double domain proteins; (3) MarR homologs. Structural studies have also demonstrated that SarA, SarR, SarS, MgrA and thus possibly all members of this protein family are winged helix proteins with minor variations. Mutagenesis studies of SarA disclose that the winged helix motifs are important for DNA binding and function. Recent progress concerning the functions and plausible mechanisms of regulation of SarA and its homologs are discussed. Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that S. aureus infections can now occur in other wise healthy individuals in the community setting. The success of this organism can be attributed to the large array of regulatory proteins, including the SarA protein family, used to respond to changing microenvironments. Sequence alignment and structural data reveal that the SarA protein family can be divided into three subfamilies: (1) single domain proteins; (2) double domain proteins; (3) MarR homologs. Structural studies have also demonstrated that SarA, SarR, SarS, MgrA and thus possibly all members of this protein family are winged helix proteins with minor variations. Mutagenesis studies of SarA disclose that the winged helix motifs are important for DNA binding and function. Recent progress concerning the functions and plausible mechanisms of regulation of SarA and its homologs are discussed. |
| Author | Nishina, Koren A. Cheung, Ambrose L. Tamber, Sandeep Trotonda, Maria Pilar |
| Author_xml | – sequence: 1 givenname: Ambrose L. surname: Cheung fullname: Cheung, Ambrose L. email: ambrose.cheung@dartmouth.edu – sequence: 2 givenname: Koren A. surname: Nishina fullname: Nishina, Koren A. – sequence: 3 givenname: Maria Pilar surname: Trotonda fullname: Trotonda, Maria Pilar – sequence: 4 givenname: Sandeep surname: Tamber fullname: Tamber, Sandeep |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18083623$$D View this record in MEDLINE/PubMed |
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| Snippet | Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that
S.... Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that S.... Staphylococcus aureus is widely appreciated as an opportunistic pathogen, primarily in hospital-related infections. However, recent reports indicate that S.... |
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| SubjectTerms | Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - metabolism Gene regulation Humans Molecular Sequence Data Protein Structure, Secondary SarA SarA protein family Sequence Alignment Staphylococcal Infections - microbiology Staphylococcus aureus - metabolism Staphylococcus aureus - pathogenicity Stapylococcus Virulence |
| Title | The SarA protein family of Staphylococcus aureus |
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