The Antifungal Activity of Naphthoquinones: An Integrative Review

Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synth...

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Published inAnais da Academia Brasileira de Ciências Vol. 90; no. 1 suppl 2; pp. 1187 - 1214
Main Authors FUTURO, DÉBORA O., FERREIRA, PATRICIA G., NICOLETTI, CAROLINE D., BORBA-SANTOS, LUANA P., SILVA, FERNANDO C. DA, ROZENTAL, SONIA, FERREIRA, VITOR FRANCISCO
Format Journal Article
LanguageEnglish
Published Brazil Academia Brasileira de Ciências 2018
Subjects
Antifungal Agents - chemistry
Antifungal Agents - classification
Antifungal Agents - pharmacology
Candida - drug effects
Candida spp
disc diffusion method
Humans
lapachol
lawsone
Microbial Sensitivity Tests
MULTIDISCIPLINARY SCIENCES
Naphthoquinones - chemistry
Naphthoquinones - classification
Naphthoquinones - pharmacology
Quinones
xanthenes
Candida spp
Quinones
disc diffusion method
lawsone
xanthenes
lapachol
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Abstract Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.
AbstractList Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.
ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.
Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.
Author FERREIRA, PATRICIA G.
BORBA-SANTOS, LUANA P.
SILVA, FERNANDO C. DA
NICOLETTI, CAROLINE D.
FUTURO, DÉBORA O.
ROZENTAL, SONIA
FERREIRA, VITOR FRANCISCO
AuthorAffiliation Universidade Federal Fluminense
Universidade Federal do Rio de Janeiro
AuthorAffiliation_xml – name: Universidade Federal Fluminense
– name: Universidade Federal do Rio de Janeiro
Author_xml – sequence: 1
  givenname: DÉBORA O.
  surname: FUTURO
  fullname: FUTURO, DÉBORA O.
  organization: Universidade Federal Fluminense, Brazil
– sequence: 2
  givenname: PATRICIA G.
  surname: FERREIRA
  fullname: FERREIRA, PATRICIA G.
  organization: Universidade Federal Fluminense, Brazil
– sequence: 3
  givenname: CAROLINE D.
  surname: NICOLETTI
  fullname: NICOLETTI, CAROLINE D.
  organization: Universidade Federal Fluminense, Brazil
– sequence: 4
  givenname: LUANA P.
  surname: BORBA-SANTOS
  fullname: BORBA-SANTOS, LUANA P.
  organization: Universidade Federal do Rio de Janeiro, Brazil
– sequence: 5
  givenname: FERNANDO C. DA
  surname: SILVA
  fullname: SILVA, FERNANDO C. DA
  organization: Universidade Federal Fluminense, Brazil
– sequence: 6
  givenname: SONIA
  surname: ROZENTAL
  fullname: ROZENTAL, SONIA
  organization: Universidade Federal do Rio de Janeiro, Brazil
– sequence: 7
  givenname: VITOR FRANCISCO
  surname: FERREIRA
  fullname: FERREIRA, VITOR FRANCISCO
  organization: Universidade Federal Fluminense, Brazil
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Issue 1 suppl 2
Keywords Candida spp
Quinones
disc diffusion method
lawsone
xanthenes
lapachol
Language English
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Snippet Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants,...
ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in...
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SubjectTerms Antifungal Agents - chemistry
Antifungal Agents - classification
Antifungal Agents - pharmacology
Candida - drug effects
Candida spp
disc diffusion method
Humans
lapachol
lawsone
Microbial Sensitivity Tests
MULTIDISCIPLINARY SCIENCES
Naphthoquinones - chemistry
Naphthoquinones - classification
Naphthoquinones - pharmacology
Quinones
xanthenes
Title The Antifungal Activity of Naphthoquinones: An Integrative Review
URI https://www.ncbi.nlm.nih.gov/pubmed/29873671
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