Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages

• Published in: PloS one Vol. 19; no. 5; p. e0303556
• Main Authors: Luo, Liuling, Wang, Huan, Xiong, Jinrui, Chen, Xiaorui, Shen, Xiaofei, Zhang, Hai
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.05.2024; Public Library of Science (PLoS)
• Subjects: Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Alveoli; Animals; Anti-Inflammatory Agents - pharmacology; Antibodies; Biology and Life Sciences; Cell culture; Cyclooxygenase-2; Cytokines; Gene expression; Growth factors; Heme oxygenase (decyclizing); Heme Oxygenase-1 - metabolism; Herbal medicine; IL-1β; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Inflammatory diseases; Injuries; Interleukin 6; Kelch-Like ECH-Associated Protein 1 - metabolism; Kinases; Lipopolysaccharides; Lungs; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Male; MAP kinase; MAP Kinase Kinase Kinases - metabolism; Medicine and Health Sciences; Membrane Proteins - metabolism; Mice; Molecular modelling; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; NF-κB protein; Nitric oxide; Nitric-oxide synthase; Oxidative stress; Physical Sciences; Prostaglandin E2; Proteins; RAW 264.7 Cells; Reagents; Signal Transduction - drug effects; TAK1 protein; Traditional Chinese medicine; Western blotting; United States > US; China; Germany

Echinatin is an active ingredient in licorice, a traditional Chinese medicine used in the treatment of inflammatory disorders. However, the protective effect and underlying mechanism of echinatin against acute lung injury (ALI) is still unclear. Herein, we aimed to explore echinatin-mediated anti-in...