Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages - Luo, Liuling; Wang, Huan; Xiong, Jinrui; Chen, Xiaorui; Shen, Xiaofei; Zhang, Hai (PloS one, 2024)
Keywords: Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Alveoli; Animals; Anti-Inflammatory Agents - pharmacology; Antibodies; Biology and Life Sciences; Cell culture; Cyclooxygenase-2; Cytokines; Gene expression; Growth factors; Heme oxygenase (decyclizing); Heme Oxygenase-1 - metabolism; Herbal medicine; IL-1β; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Inflammatory diseases; Injuries; Interleukin 6; Kelch-Like ECH-Associated Protein 1 - metabolism; Kinases; Lipopolysaccharides; Lungs; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Male; MAP kinase; MAP Kinase Kinase Kinases - metabolism; Medicine and Health Sciences; Membrane Proteins - metabolism; Mice; Molecular modelling; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; NF-κB protein; Nitric oxide; Nitric-oxide synthase; Oxidative stress; Physical Sciences; Prostaglandin E2; Proteins; RAW 264.7 Cells; Reagents; Signal Transduction - drug effects; TAK1 protein; Traditional Chinese medicine; Western blotting; United States--US; China; Germany