Towards Scarless Wound Healing : A Comparison of Protein Expression between Human, Adult and Foetal Fibroblasts

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 10
• Main Authors: Ho, Sonia, Marçal, Helder, Foster, Leslie John Ray
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Adult; Cicatrix - genetics; Cicatrix - metabolism; Collagen; Electrophoresis, Gel, Two-Dimensional; Extracellular matrix; Fetus - metabolism; Fibroblasts; Fibroblasts - metabolism; Gene expression; Gene Expression Regulation, Developmental; Humans; Protein Biosynthesis - genetics; Protein expression; Protein Processing, Post-Translational; Proteins; Proteomics; RNA, Messenger - metabolism; Skin; Studies; Tissue engineering; Wound healing; Wound Healing - genetics; Australia

Proteins from human adult and foetal fibroblast cell lines were compared, focusing on those involved in wound healing. Proteins were separated through two-dimensional gel electrophoresis (2DE). Differences in protein spot intensity between the lineages were quantified through 3D gel scanning densito...