Integrating Epidermal Growth Factor Receptor Assay With Clinical Parameters Improves Risk Classification for Relapse and Survival in Head-and-Neck Squamous Cell Carcinoma

• Published in: International journal of radiation oncology, biology, physics Vol. 81; no. 2; pp. 331 - 338
• Main Authors: Chung, Christine H., Zhang, Qiang, Hammond, Elizabeth M., Trotti, Andy M., Wang, Huijun, Spencer, Sharon, Zhang, Hua-Zhong, Cooper, Jay, Jordan, Richard, Rotman, Marvin H., Ang, K. Kian
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2011; Elsevier
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - metabolism; BODY; Carcinoma, Squamous Cell - blood supply; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; CARCINOMAS; CLINICAL TRIALS; Disease-Free Survival; DISEASES; Dose Fractionation, Radiation; Epidermal growth factor receptor; ErbB Receptors - metabolism; Female; GROWTH FACTORS; HAZARDS; HEAD; Head and Neck Neoplasms - blood supply; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Head-and-neck squamous cell carcinoma; Hematology, Oncology and Palliative Medicine; Humans; Karnofsky Performance Status; Ki-67 Antigen - metabolism; Male; Medical sciences; MEDICINE; MEMBRANE PROTEINS; Microvessels - pathology; Middle Aged; MITOGENS; NECK; Neoplasm Recurrence, Local - mortality; NEOPLASMS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Prognosis; Proportional Hazards Models; PROTEINS; RADIOLOGY; RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; RECEPTORS; Reproducibility of Results; Risk Assessment - classification; Risk classification; TESTING; THERAPY; Tumor Suppressor Protein p53 - metabolism; Tumors; Risk classification; Head-and-neck squamous cell carcinoma; Prognosis; Epidermal growth factor receptor; Risk factor; ENT disease; Head and neck cancer; Head and neck squamous cell carcinoma; Malignant tumor; Survival; Cancer

Epidermal growth factor receptor (EGFR) overexpression has been consistently found to be an independent predictor of local-regional relapse (LRR) after radiotherapy. We assessed the extent by which it can refine risk classification for overall survival (OS) and LRR in patients with head-and-neck squ...