Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 21; p. 5075
• Main Authors: Feng, Liwen, Pomel, Sébastien, Latre de Late, Perle, Taravaud, Alexandre, Loiseau, Philippe M, Maes, Louis, Cho-Ngwa, Fidelis, Bulman, Christina A, Fischer, Chelsea, Sakanari, Judy A, Ziniel, Peter D, Williams, David L, Davioud-Charvet, Elisabeth
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2020; MDPI
• Subjects: Amastigotes; Animals; Anthelmintics - chemistry; Anthelmintics - pharmacology; anti-amoeba; anti-helminth; anti-leishmanial; anti-trypanosomal; anticancer; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; antiparasitic; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Auranofin - chemistry; Auranofin - pharmacology; Bacterial infections; Bioavailability; Brain tumors; Breast; Cattle; Cell Line, Tumor; Chemical Sciences; Coordination chemistry; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Drug Evaluation; Drug resistance; Enzymes; Gold; Gold - chemistry; Gold - pharmacology; Helminthiasis - drug therapy; Helminthiasis - metabolism; Helminthiasis - pathology; Humans; Infections; Life Sciences; Ligands; Medication; Metabolism; Molecular weight; Nematodes; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Oral administration; Organic chemistry; Parasites; Parasitic diseases; Pharmaceutical sciences; Proteins; Protozoa; Protozoan Infections - drug therapy; Protozoan Infections - metabolism; Protozoan Infections - pathology; Public health; Reductases; Selenium; Thioredoxin; Tropical diseases; Worms; anti-leishmanial; auranofin; gold(I) complex; thioredoxin; glutathione; antiparasitic; anti-amoeba; anti-helminth; anti-trypanosomal; anticancer; redox equilibrium

Neglected parasitic diseases remain a major public health issue worldwide, especially in tropical and subtropical areas. Human parasite diversity is very large, ranging from protozoa to worms. In most cases, more effective and new drugs are urgently needed. Previous studies indicated that the gold(I...