Exclusion of Actin-Binding Protein p57/Coronin-1 from Bacteria-Containing Phagosomes in Macrophages Infected with Legionella

• Published in: Biological & pharmaceutical bulletin Vol. 31; no. 5; pp. 861 - 865
• Main Authors: Hayashi, Tsuyoshi, Miyake, Masaki, Fukui, Takashi, Sugaya, Noriko, Daimon, Takashi, Itoh, Saotomo, Oku, Teruaki, Tsuji, Tsutomu, Toyoshima, Satoshi, Imai, Yasuyuki
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.05.2008; Japan Science and Technology Agency
• Subjects: 4-Butyrolactone - analogs & derivatives; 4-Butyrolactone - metabolism; Actin; Actins - metabolism; Bacteria; Bacteria - metabolism; Carrier Proteins - metabolism; Cell Line; cytochalasin D; Cytochalasins - metabolism; F-actin; Fluorescent Dyes; Humans; Legionella gratiana; Legionella pneumophila; Legionella pneumophila - metabolism; Legionnaires' Disease - metabolism; Legionnaires' Disease - microbiology; Macrophages - metabolism; Macrophages - microbiology; Microfilament Proteins - metabolism; Microscopy, Confocal; p57/coronin-1; Phagosomes - metabolism; Xanthenes; Zymosan - metabolism

Legionella pneumophila, the causative agent of Legionnaires' disease, is a human pathogen that multiplies within alveolar macrophages. L. pneumophila establishes specialized phagosomes in which it evades the host defense through largely unknown mechanisms. Here we analyzed the role of an actin-...