Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker

• Published in: Nature nanotechnology Vol. 5; no. 11; pp. 778 - 782
• Main Authors: He, Yu, Liu, David R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2010
• Subjects: 631/92/60; 639/638/403; 639/925/350; 639/925/927/339; Base Sequence; Chemistry and Materials Science; Chemistry, Organic - methods; DNA - chemical synthesis; DNA - chemistry; Hybridization, Genetic; letter; Mass Spectrometry; Materials Science; Nanotechnology; Nanotechnology - methods; Nanotechnology and Microengineering; Solutions; Templates, Genetic

Multistep synthesis in the laboratory typically requires numerous reaction vessels, each containing a different set of reactants. In contrast, cells are capable of performing highly efficient and selective multistep biosynthesis under mild conditions with all reactants simultaneously present in solu...