Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment

• Published in: Biomedicine & pharmacotherapy Vol. 142; p. 112074
• Main Authors: Yang, Shuxian, Xiao, Haiyan, Cao, Li
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2021
• Subjects: Animals; Antineoplastic Agents - pharmacology; Biomarker; Biomarkers, Tumor - metabolism; Cancer diagnosis and prognosis; Cancer metabolism; Disease Progression; Heat shock proteins (HSPs); Heat-Shock Proteins - chemistry; Heat-Shock Proteins - metabolism; HSP inhibitors; HSP-based immunotherapies; Humans; Molecular Targeted Therapy; Molecular Weight; Neoplasms - diagnosis; Neoplasms - pathology; Neoplasms - therapy; Prognosis; CLL; Heat shock proteins (HSPs); OXPHOS; HIF-1α; DFS; TNM; PI3K; Cancer metabolism; SDH; VEGFR; MCLs; HSF; HSP inhibitors; HBV; PSA; CML; HSR; EAC; BCG; HCC; ER; GRP94; ESCC; 17-DMAG; BCR; AR; RD; PDAC; HSEs; 17-AAG; HCV; Cancer diagnosis and prognosis; NK; IVM; Biomarker; nChap; HSPs; HSP-based immunotherapies; GA; OSCC; APCs; SCLC; TRAP1; OS; NSCLC; PKM2; AKT; MHC I; ccRCC; gp96; PES

Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and lar...