Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment

Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and lar...

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Published inBiomedicine & pharmacotherapy Vol. 142; p. 112074
Main Authors Yang, Shuxian, Xiao, Haiyan, Cao, Li
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.10.2021
Subjects
Animals
Antineoplastic Agents - pharmacology
Biomarker
Biomarkers, Tumor - metabolism
Cancer diagnosis and prognosis
Cancer metabolism
Disease Progression
Heat shock proteins (HSPs)
Heat-Shock Proteins - chemistry
Heat-Shock Proteins - metabolism
HSP inhibitors
HSP-based immunotherapies
Humans
Molecular Targeted Therapy
Molecular Weight
Neoplasms - diagnosis
Neoplasms - pathology
Neoplasms - therapy
Prognosis
CLL
Heat shock proteins (HSPs)
OXPHOS
HIF-1α
DFS
TNM
PI3K
Cancer metabolism
SDH
VEGFR
MCLs
HSF
HSP inhibitors
HBV
PSA
CML
HSR
EAC
BCG
HCC
ER
GRP94
ESCC
17-DMAG
BCR
AR
RD
PDAC
HSEs
17-AAG
HCV
Cancer diagnosis and prognosis
NK
IVM
Biomarker
nChap
HSPs
HSP-based immunotherapies
GA
OSCC
APCs
SCLC
TRAP1
OS
NSCLC
PKM2
AKT
MHC I
ccRCC
gp96
PES
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Abstract Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. Previous studies have revealed that HSPs play important roles in oncogenesis and malignant progression because they can modulate all six hallmark traits of cancer. Because of this, HSPs have been propelled into the spotlight as biomarkers for cancer diagnosis and prognosis, as well as an exciting anticancer drug target. However, the relationship between the expression level of HSPs and their activity and cancer diagnosis, prognosis, metabolism and treatment is not clear and has not been completely established. Herein, this review summarizes and discusses recent advances and perspectives in major HSPs as biomarkers for cancer diagnosis, as regulators for cancer metabolism or as therapeutic targets for cancer therapy, which may provide new directions to improve the accuracy of cancer diagnosis and develop more effective and safer anticancer therapeutics. [Display omitted] •HSF-1 and HSPs can be used as biomarkers for cancer diagnosis and prognosis.•HSPs, particularly HSP70 and HSP90, participate in and regulate cancer metabolism.•Two approaches are employed to target HSPs for cancer therapy, including HSP inhibitors and HSP-based immunotherapies.•The combination of the HSP inhibitors with conventional therapies will help improve the therapeutic outcome.•HSP-based targeting or immunotherapy will remain a major focus in the field of cancer therapy.
AbstractList Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. Previous studies have revealed that HSPs play important roles in oncogenesis and malignant progression because they can modulate all six hallmark traits of cancer. Because of this, HSPs have been propelled into the spotlight as biomarkers for cancer diagnosis and prognosis, as well as an exciting anticancer drug target. However, the relationship between the expression level of HSPs and their activity and cancer diagnosis, prognosis, metabolism and treatment is not clear and has not been completely established. Herein, this review summarizes and discusses recent advances and perspectives in major HSPs as biomarkers for cancer diagnosis, as regulators for cancer metabolism or as therapeutic targets for cancer therapy, which may provide new directions to improve the accuracy of cancer diagnosis and develop more effective and safer anticancer therapeutics.Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. Previous studies have revealed that HSPs play important roles in oncogenesis and malignant progression because they can modulate all six hallmark traits of cancer. Because of this, HSPs have been propelled into the spotlight as biomarkers for cancer diagnosis and prognosis, as well as an exciting anticancer drug target. However, the relationship between the expression level of HSPs and their activity and cancer diagnosis, prognosis, metabolism and treatment is not clear and has not been completely established. Herein, this review summarizes and discusses recent advances and perspectives in major HSPs as biomarkers for cancer diagnosis, as regulators for cancer metabolism or as therapeutic targets for cancer therapy, which may provide new directions to improve the accuracy of cancer diagnosis and develop more effective and safer anticancer therapeutics.
Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. Previous studies have revealed that HSPs play important roles in oncogenesis and malignant progression because they can modulate all six hallmark traits of cancer. Because of this, HSPs have been propelled into the spotlight as biomarkers for cancer diagnosis and prognosis, as well as an exciting anticancer drug target. However, the relationship between the expression level of HSPs and their activity and cancer diagnosis, prognosis, metabolism and treatment is not clear and has not been completely established. Herein, this review summarizes and discusses recent advances and perspectives in major HSPs as biomarkers for cancer diagnosis, as regulators for cancer metabolism or as therapeutic targets for cancer therapy, which may provide new directions to improve the accuracy of cancer diagnosis and develop more effective and safer anticancer therapeutics. [Display omitted] •HSF-1 and HSPs can be used as biomarkers for cancer diagnosis and prognosis.•HSPs, particularly HSP70 and HSP90, participate in and regulate cancer metabolism.•Two approaches are employed to target HSPs for cancer therapy, including HSP inhibitors and HSP-based immunotherapies.•The combination of the HSP inhibitors with conventional therapies will help improve the therapeutic outcome.•HSP-based targeting or immunotherapy will remain a major focus in the field of cancer therapy.
Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to stresses or high temperature. According to their molecular weights, mammalian HSPs are classified into HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. Previous studies have revealed that HSPs play important roles in oncogenesis and malignant progression because they can modulate all six hallmark traits of cancer. Because of this, HSPs have been propelled into the spotlight as biomarkers for cancer diagnosis and prognosis, as well as an exciting anticancer drug target. However, the relationship between the expression level of HSPs and their activity and cancer diagnosis, prognosis, metabolism and treatment is not clear and has not been completely established. Herein, this review summarizes and discusses recent advances and perspectives in major HSPs as biomarkers for cancer diagnosis, as regulators for cancer metabolism or as therapeutic targets for cancer therapy, which may provide new directions to improve the accuracy of cancer diagnosis and develop more effective and safer anticancer therapeutics.
ArticleNumber 112074
Author Yang, Shuxian
Cao, Li
Xiao, Haiyan
Author_xml – sequence: 1
  givenname: Shuxian
  surname: Yang
  fullname: Yang, Shuxian
  organization: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
– sequence: 2
  givenname: Haiyan
  surname: Xiao
  fullname: Xiao, Haiyan
  organization: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
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  surname: Cao
  fullname: Cao, Li
  email: lcao@implad.ac.cn
  organization: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
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Keywords CLL
Heat shock proteins (HSPs)
OXPHOS
HIF-1α
DFS
TNM
PI3K
Cancer metabolism
SDH
VEGFR
MCLs
HSF
HSP inhibitors
HBV
PSA
CML
HSR
EAC
BCG
HCC
ER
GRP94
ESCC
17-DMAG
BCR
AR
RD
PDAC
HSEs
17-AAG
HCV
Cancer diagnosis and prognosis
NK
IVM
Biomarker
nChap
HSPs
HSP-based immunotherapies
GA
OSCC
APCs
SCLC
TRAP1
OS
NSCLC
PKM2
AKT
MHC I
ccRCC
gp96
PES
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
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OpenAccessLink https://www.sciencedirect.com/science/article/pii/S075333222100857X
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crossref_primary_10_1016_j_biopha_2021_112074
elsevier_sciencedirect_doi_10_1016_j_biopha_2021_112074
elsevier_clinicalkey_doi_10_1016_j_biopha_2021_112074
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PublicationCentury 2000
PublicationDate October 2021
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2021-Oct
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PublicationDateYYYYMMDD 2021-10-01
PublicationDate_xml – month: 10
  year: 2021
  text: October 2021
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PublicationTitle Biomedicine & pharmacotherapy
PublicationTitleAlternate Biomed Pharmacother
PublicationYear 2021
Publisher Elsevier Masson SAS
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Snippet Heat shock proteins (HSPs) are a group of proteins, also known as molecular chaperones, which participate in protein folding and maturation in response to...
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SubjectTerms Animals
Antineoplastic Agents - pharmacology
Biomarker
Biomarkers, Tumor - metabolism
Cancer diagnosis and prognosis
Cancer metabolism
Disease Progression
Heat shock proteins (HSPs)
Heat-Shock Proteins - chemistry
Heat-Shock Proteins - metabolism
HSP inhibitors
HSP-based immunotherapies
Humans
Molecular Targeted Therapy
Molecular Weight
Neoplasms - diagnosis
Neoplasms - pathology
Neoplasms - therapy
Prognosis
Title Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment
URI https://www.clinicalkey.com/#!/content/1-s2.0-S075333222100857X
https://dx.doi.org/10.1016/j.biopha.2021.112074
https://www.ncbi.nlm.nih.gov/pubmed/34426258
https://www.proquest.com/docview/2564131490
Volume 142
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