ancient autosomal haplotype bearing a rare achromatopsia-causing founder mutation is shared among Arab Muslims and Oriental Jews

• Published in: Human genetics Vol. 128; no. 3; pp. 261 - 267
• Main Authors: Zelinger, Lina, Greenberg, Alex, Kohl, Susanne, Banin, Eyal, Sharon, Dror
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.09.2010; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Alleles; Analysis; Arabs - genetics; Biomedical and Life Sciences; Biomedicine; Color blindness; Color Vision Defects - genetics; Consanguinity; Cyclic Nucleotide-Gated Cation Channels - genetics; Founder Effect; Gene Frequency; Gene Function; Genes; Genetic aspects; Genomics; Haplotypes; Homozygote; Human Genetics; Humans; Islam; Israel; Jews; Jews - genetics; Metabolic Diseases; Middle East; Molecular Medicine; Muslims; Original Investigation; Point Mutation; Polymorphism, Single Nucleotide; Time Factors; Middle East; Israel; Single Nucleotide Polymorphism Analysis; Jewish Patient; Jewish Population; Single Nucleotide Polymorphism Marker; Founder Mutation

Numerous cultural aspects, mainly based on historical records, suggest a common origin of the Middle-Eastern Arab Muslim and Jewish populations. This is supported, to some extent, by Y-chromosome haplogroup analysis of Middle-Eastern and European samples. Up to date, no genomic regions that are shar...