The roles of ZEB1 in tumorigenic progression and epigenetic modifications
Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and activation of ZEB1 play important roles in cancer transformation and epithelial-mesenchymal transition (EMT). Emerging evidence suggests that ZEB1 d...
Saved in:
| Published in | Biomedicine & pharmacotherapy Vol. 110; pp. 400 - 408 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
France
Elsevier Masson SAS
01.02.2019
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0753-3322 1950-6007 1950-6007 |
| DOI | 10.1016/j.biopha.2018.11.112 |
Cover
Loading…
| Abstract | Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and activation of ZEB1 play important roles in cancer transformation and epithelial-mesenchymal transition (EMT). Emerging evidence suggests that ZEB1 drives the induction of EMT with activation of stem cell traits, immune evasion and epigenetic reprogramming. As an ideal target for EMT research, ZEB1 has been extensively studied for decades. However, the link between ZEB1 and epigenetic regulation of EMT has only recently been discovered. ZEB1 facilitates the epigenetic silencing of E-cadherin by recruiting multiple chromatin enzymes of E-cadherin promoter, such as histone deacetylases (HDACs), DNA methyltransferase (DNMT) and ubiquitin ligase. Destruction of the connection between ZEB1 and these chromatin-modifying enzymes may represent an efficient for treating cancer. In this review, we outlined the biological function of ZEB1 in tumorigenic progression and epigenetic modifications and elucidate its transcriptional network, which is a suitable potential target for the design of novel anticancer drugs. |
|---|---|
| AbstractList | Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and activation of ZEB1 play important roles in cancer transformation and epithelial-mesenchymal transition (EMT). Emerging evidence suggests that ZEB1 drives the induction of EMT with activation of stem cell traits, immune evasion and epigenetic reprogramming. As an ideal target for EMT research, ZEB1 has been extensively studied for decades. However, the link between ZEB1 and epigenetic regulation of EMT has only recently been discovered. ZEB1 facilitates the epigenetic silencing of E-cadherin by recruiting multiple chromatin enzymes of E-cadherin promoter, such as histone deacetylases (HDACs), DNA methyltransferase (DNMT) and ubiquitin ligase. Destruction of the connection between ZEB1 and these chromatin-modifying enzymes may represent an efficient for treating cancer. In this review, we outlined the biological function of ZEB1 in tumorigenic progression and epigenetic modifications and elucidate its transcriptional network, which is a suitable potential target for the design of novel anticancer drugs.Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and activation of ZEB1 play important roles in cancer transformation and epithelial-mesenchymal transition (EMT). Emerging evidence suggests that ZEB1 drives the induction of EMT with activation of stem cell traits, immune evasion and epigenetic reprogramming. As an ideal target for EMT research, ZEB1 has been extensively studied for decades. However, the link between ZEB1 and epigenetic regulation of EMT has only recently been discovered. ZEB1 facilitates the epigenetic silencing of E-cadherin by recruiting multiple chromatin enzymes of E-cadherin promoter, such as histone deacetylases (HDACs), DNA methyltransferase (DNMT) and ubiquitin ligase. Destruction of the connection between ZEB1 and these chromatin-modifying enzymes may represent an efficient for treating cancer. In this review, we outlined the biological function of ZEB1 in tumorigenic progression and epigenetic modifications and elucidate its transcriptional network, which is a suitable potential target for the design of novel anticancer drugs. Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and activation of ZEB1 play important roles in cancer transformation and epithelial-mesenchymal transition (EMT). Emerging evidence suggests that ZEB1 drives the induction of EMT with activation of stem cell traits, immune evasion and epigenetic reprogramming. As an ideal target for EMT research, ZEB1 has been extensively studied for decades. However, the link between ZEB1 and epigenetic regulation of EMT has only recently been discovered. ZEB1 facilitates the epigenetic silencing of E-cadherin by recruiting multiple chromatin enzymes of E-cadherin promoter, such as histone deacetylases (HDACs), DNA methyltransferase (DNMT) and ubiquitin ligase. Destruction of the connection between ZEB1 and these chromatin-modifying enzymes may represent an efficient for treating cancer. In this review, we outlined the biological function of ZEB1 in tumorigenic progression and epigenetic modifications and elucidate its transcriptional network, which is a suitable potential target for the design of novel anticancer drugs. |
| Author | Xu, Lei Li, Anqi Han, Xiuzhen Zhang, Yu |
| Author_xml | – sequence: 1 givenname: Yu surname: Zhang fullname: Zhang, Yu organization: Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, Shandong Province, China – sequence: 2 givenname: Lei surname: Xu fullname: Xu, Lei organization: Pharmaceutical Preparation Section, Hospital of Laiwu Steel Group, 68 Xinxing Road, Laigang 271126, Shandong Province, China – sequence: 3 givenname: Anqi surname: Li fullname: Li, Anqi organization: Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, Shandong Province, China – sequence: 4 givenname: Xiuzhen surname: Han fullname: Han, Xiuzhen email: xzyhan@sdu.edu.cn organization: Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, Shandong Province, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30530042$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU9r3DAQxUVJaTZ_vkEpPvbi7YxkyXIphTSkbSDQS3rJRcjSONHWtraSt5BvXzubXHJZGNDhvd9D8-aEHY1xJMbeI6wRUH3arNsQtw92zQH1GnEe_oatsJFQKoD6iK2glqIUgvNjdpLzBgCkEvodOxYgBUDFV-z69oGKFHvKReyKu6tvWISxmHZDTOGexuCKbYr3iXIOcSzs6AvaLgJNszREH7rg7DRr-Yy97Wyf6fz5PWW_v1_dXv4sb379uL68uCmd5PVUSu8brXXbqI6g84hONb7mWgskqLQVLTS8FV5qVSspdC3Ra0et4m1rlW_EKfu4z50_9ndHeTJDyI763o4Ud9lwlBJlVcnF-uHZumsH8mabwmDTo3lZfzZ83htcijkn6owL09M6U7KhNwhm6dpszL5rs3RtEOdZ4OoV_JJ_APu6x2gu6V-gZLILNDryIZGbjI_hUMCXVwGuD_OlbP-HHg_j_wHR-a2a |
| CitedBy_id | crossref_primary_10_1210_endocr_bqae116 crossref_primary_10_1002_cbf_3544 crossref_primary_10_1038_s41598_019_53915_7 crossref_primary_10_1242_dmm_045989 crossref_primary_10_1113_EP090212 crossref_primary_10_3390_ijms22073591 crossref_primary_10_1016_j_envint_2024_108656 crossref_primary_10_1016_j_lfs_2023_122407 crossref_primary_10_3389_fonc_2021_762817 crossref_primary_10_18632_aging_205029 crossref_primary_10_3390_jcm12175652 crossref_primary_10_3390_ijms22179589 crossref_primary_10_1038_s41419_021_03601_2 crossref_primary_10_1186_s13045_020_00858_6 crossref_primary_10_1039_D1NH00254F crossref_primary_10_1016_j_semcancer_2022_11_001 crossref_primary_10_1016_j_critrevonc_2022_103598 crossref_primary_10_1038_s41598_020_75286_0 crossref_primary_10_1080_15384047_2024_2427415 crossref_primary_10_37349_ei_2025_1003187 crossref_primary_10_1007_s12272_024_01514_0 crossref_primary_10_3390_cancers12061586 crossref_primary_10_4049_jimmunol_2200682 crossref_primary_10_1038_s41598_024_56511_6 crossref_primary_10_1007_s10565_021_09680_3 crossref_primary_10_3390_biology12060818 crossref_primary_10_1186_s13578_022_00913_4 crossref_primary_10_1007_s11033_022_07563_2 crossref_primary_10_2147_OTT_S250370 crossref_primary_10_1038_s41388_021_02128_2 crossref_primary_10_3390_cancers13163996 crossref_primary_10_3390_genes12091302 crossref_primary_10_1158_2767_9764_CRC_24_0272 crossref_primary_10_1016_S1470_2045_21_00343_0 crossref_primary_10_1016_j_canlet_2021_03_015 crossref_primary_10_1186_s13046_020_1521_4 crossref_primary_10_3892_mmr_2019_10381 crossref_primary_10_3390_ijms21217872 crossref_primary_10_3389_fcell_2021_701175 crossref_primary_10_1002_med_21966 crossref_primary_10_1186_s12860_022_00420_x crossref_primary_10_18632_aging_204035 crossref_primary_10_4103_ijpm_ijpm_530_21 crossref_primary_10_1186_s12967_024_05389_z crossref_primary_10_3389_fphar_2019_00137 crossref_primary_10_1002_mc_23364 crossref_primary_10_3390_cancers13194985 crossref_primary_10_1002_1878_0261_13486 crossref_primary_10_1038_s41598_021_90047_3 crossref_primary_10_1016_j_ejphar_2019_172745 crossref_primary_10_1016_j_bcp_2022_115262 crossref_primary_10_1177_1533033820956988 crossref_primary_10_3390_pathogens13121070 crossref_primary_10_3390_ijms23010103 crossref_primary_10_1007_s12094_023_03110_y crossref_primary_10_3390_cancers13205099 crossref_primary_10_3390_cells10040925 crossref_primary_10_1007_s10528_023_10507_5 crossref_primary_10_1016_j_compbiolchem_2022_107714 crossref_primary_10_1515_hsz_2019_0350 crossref_primary_10_1016_j_jare_2024_02_022 crossref_primary_10_2174_1566523221999210120210017 crossref_primary_10_3390_ijms222212604 crossref_primary_10_1186_s13148_023_01605_7 crossref_primary_10_3389_fcell_2020_570305 crossref_primary_10_3389_fmolb_2020_00036 crossref_primary_10_3390_cancers13153688 crossref_primary_10_1007_s00432_022_04398_z crossref_primary_10_1016_j_colsurfb_2020_111421 crossref_primary_10_1016_j_bioadv_2024_213829 crossref_primary_10_1007_s12272_023_01427_4 crossref_primary_10_3390_genes12121900 crossref_primary_10_1007_s13205_024_03941_8 crossref_primary_10_1002_jcp_30177 crossref_primary_10_1186_s13046_019_1375_9 crossref_primary_10_1007_s43032_021_00713_0 crossref_primary_10_1186_s12974_022_02636_2 crossref_primary_10_3390_ijms22136768 crossref_primary_10_22141_2224_0721_20_7_2024_1451 crossref_primary_10_3389_fcell_2023_1034604 crossref_primary_10_2174_1568009621666210601114631 crossref_primary_10_1016_j_cclet_2021_02_004 crossref_primary_10_3390_biomedicines9020178 crossref_primary_10_1155_2022_6048017 crossref_primary_10_1177_15330338241252423 crossref_primary_10_1186_s13046_024_03241_2 crossref_primary_10_3389_fphar_2022_879704 crossref_primary_10_15430_JCP_2023_28_4_150 crossref_primary_10_3390_biology9070143 crossref_primary_10_1016_j_tox_2020_152521 crossref_primary_10_3389_fonc_2022_854773 crossref_primary_10_1016_j_trsl_2020_12_003 crossref_primary_10_1111_jcmm_15491 crossref_primary_10_1111_jog_14639 crossref_primary_10_1007_s40944_021_00574_0 crossref_primary_10_1016_j_lfs_2023_122115 crossref_primary_10_3390_mps3030063 crossref_primary_10_1007_s12017_022_08716_z crossref_primary_10_3390_cells11223699 crossref_primary_10_1080_09553002_2020_1793015 crossref_primary_10_1038_s41388_022_02559_5 crossref_primary_10_1186_s13046_021_02006_5 crossref_primary_10_1111_his_14388 crossref_primary_10_1016_j_abb_2024_109896 crossref_primary_10_1016_j_jphs_2022_07_001 crossref_primary_10_1016_j_prp_2025_155838 |
| Cites_doi | 10.1007/s10555-008-9179-y 10.4161/cc.25405 10.1038/s41419-017-0087-3 10.1136/gutjnl-2011-300060 10.1002/ijc.28782 10.1093/abbs/gmv090 10.18632/oncotarget.8143 10.18632/oncotarget.14563 10.15252/emmm.201505971 10.1038/s41598-017-00079-x 10.1136/gutjnl-2011-301576 10.1073/pnas.97.12.6391 10.3892/ijo.2015.3187 10.18632/oncotarget.2825 10.1136/gutjnl-2015-310838 10.4161/cc.9.5.10839 10.3892/ijo.2016.3331 10.1172/JCI97225 10.18632/oncotarget.5968 10.1016/j.bbrc.2016.12.017 10.1016/j.bcp.2014.05.011 10.1053/j.gastro.2017.03.004 10.1038/ncomms12231 10.1038/onc.2012.334 10.18632/oncotarget.2696 10.1038/onc.2016.100 10.1016/j.pathophys.2018.05.004 10.1038/onc.2016.414 10.1016/j.oraloncology.2012.07.012 10.1172/JCI63608 10.1055/s-0029-1237423 10.1016/j.bbrc.2015.08.071 10.1016/j.biopha.2018.09.030 10.1074/jbc.M114.598383 10.1038/cdd.2014.228 10.1158/2159-8290.CD-15-1297 10.1038/bjc.2013.770 10.1080/15384101.2015.1006048 10.1158/0008-5472.CAN-16-0246 10.1038/ncb3513 10.1158/1078-0432.CCR-13-3173 10.1038/onc.2014.215 10.1146/annurev-pathol-012513-104715 10.1038/s41598-017-18101-7 10.1038/nature01550 10.18632/oncotarget.3774 10.15252/emmm.201404396 10.1002/1878-0261.12030 10.1016/j.biopha.2016.11.100 10.1091/mbc.e11-02-0103 10.1080/19336918.2015.1016686 10.1038/nature16064 10.1016/j.cell.2013.06.005 10.3322/caac.21387 10.1016/j.molcel.2015.01.023 10.1038/ncomms6660 10.1038/ncomms6241 10.3892/ijo.2017.4099 10.1093/nar/gku1293 10.1038/s41389-018-0048-4 10.18632/oncotarget.12116 10.1074/jbc.M307356200 10.1038/nrclinonc.2017.44 10.1172/JCI76725 10.1158/1078-0432.CCR-12-2675 10.1038/onc.2017.241 10.1073/pnas.1108977108 10.1158/0008-5472.CAN-3627-2 10.1016/j.cellsig.2012.08.004 10.3892/ol.2015.3943 10.1016/j.bbrc.2018.02.120 10.1038/cddis.2014.395 10.1002/iub.1917 10.1002/jcp.26634 10.1128/MCB.00079-16 10.7150/jca.18762 10.1038/srep13024 10.1038/cddis.2017.154 10.1007/s10549-013-2442-0 10.1002/jcp.21223 10.18632/oncotarget.1463 10.1074/jbc.M113.533505 10.1016/j.ccr.2014.02.025 10.1038/ncomms3650 10.1038/srep19874 10.1084/jem.20110235 10.1182/blood-2016-05-714493 10.18632/oncotarget.10521 10.3390/cancers5020334 10.1038/onc.2017.47 10.1242/jcs.100115 10.1016/j.canlet.2017.01.016 10.3892/mmr.2015.4733 10.1038/ncb3013 10.1016/j.bbadis.2018.05.013 10.1016/S0888-7543(05)80307-6 10.1007/s12032-014-0250-y 10.1016/j.pharmthera.2017.08.009 10.1038/labinvest.2016.109 10.1136/gutjnl-2011-301846 10.1172/JCI72171 10.3892/or.2013.2267 10.1016/j.stem.2009.02.015 10.1038/nrc3603 10.1186/s12885-017-3701-y 10.1186/s13046-016-0329-8 10.1002/ijc.29642 |
| ContentType | Journal Article |
| Copyright | 2018 The Authors Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
| Copyright_xml | – notice: 2018 The Authors – notice: Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.biopha.2018.11.112 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1950-6007 |
| EndPage | 408 |
| ExternalDocumentID | 30530042 10_1016_j_biopha_2018_11_112 S0753332218362048 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABMAC ABMZM ABWVN ABXDB ABZDS ACDAQ ACIEU ACIUM ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGYEJ AHHHB AI. AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALCLG ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OD~ OGGZJ OK1 OO0 OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SDF SDG SDP SEM SES SEW SPT SSH SSP SSZ T5K VH1 WUQ Z5R ~02 ~G- 0SF 6I. AACTN AAFTH AAIAV AFCTW AFKWA AFPKN AJOXV AMFUW GROUPED_DOAJ NCXOZ RIG AAYXX AGRNS CITATION NPM 7X8 |
| ID | FETCH-LOGICAL-c527t-5dd9888b96fe0fd11c69d728831e048a3b092b3d58676538751d8ceb62bba6d93 |
| IEDL.DBID | .~1 |
| ISSN | 0753-3322 1950-6007 |
| IngestDate | Fri Jul 11 03:40:55 EDT 2025 Mon Jul 21 06:18:16 EDT 2025 Thu Apr 24 23:06:42 EDT 2025 Tue Jul 01 03:23:09 EDT 2025 Sat Jun 29 15:30:30 EDT 2024 Tue Aug 26 16:34:16 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | ZEB1 MicroRNA Epigenetic EMT E-cadherin HDAC |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c527t-5dd9888b96fe0fd11c69d728831e048a3b092b3d58676538751d8ceb62bba6d93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0753332218362048 |
| PMID | 30530042 |
| PQID | 2155154459 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_2155154459 pubmed_primary_30530042 crossref_citationtrail_10_1016_j_biopha_2018_11_112 crossref_primary_10_1016_j_biopha_2018_11_112 elsevier_sciencedirect_doi_10_1016_j_biopha_2018_11_112 elsevier_clinicalkey_doi_10_1016_j_biopha_2018_11_112 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-02-01 |
| PublicationDateYYYYMMDD | 2019-02-01 |
| PublicationDate_xml | – month: 02 year: 2019 text: 2019-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | France |
| PublicationPlace_xml | – name: France |
| PublicationTitle | Biomedicine & pharmacotherapy |
| PublicationTitleAlternate | Biomed Pharmacother |
| PublicationYear | 2019 |
| Publisher | Elsevier Masson SAS |
| Publisher_xml | – name: Elsevier Masson SAS |
| References | Joseph, Conroy, Tomar, Eggens-Meijer, Bhat, Copray (bib0480) 2014; 5 Li, Mar, Zhang, Puram, Vazquez, Weir (bib0575) 2017; 129 Singh, Yelle, Venugopal, Singh (bib0025) 2018; 182 Zhang, Wei, Wang, Debeb, Yuan, Zhang (bib0120) 2014; 16 Richard, Dalle, Monet, Ligier, Boespflug, Pommier (bib0445) 2016; 8 Gao, Zhao, Zhang, Lu, Liu, Geng (bib0090) 2016; 6 Moon, Rao, Kim, Shim, Park, An (bib0410) 2015; 22 Liu, Clem, Zuba-Surma, El-Naggar, Telang, Jenson (bib0385) 2009; 4 Chen, Wong, Liu, House, Sceneay, Bowtell (bib0330) 2015; 6 Jägle, Dertmann, Schrempp, Hecht (bib0560) 2017; 482 Dong, Karaayvaz, Jia, Kaneuchi, Hamada, Watari (bib0300) 2013; 32 Yang, Ahn, Chen, Tan, Guo, Gibbons (bib0285) 2014; 124 Pan, Jiang, Cheng, Wang, Ren, Li (bib0525) 2016; 7 Yun, Baek, Xie, Tseng, Dobin, Hernandez (bib0030) 2015; 34 Bai, Ye, Zhang, Zhu, Xi, Huang (bib0110) 2014; 135 Kim, Veronese, Pichiorri, Lee, Jeon, Volinia (bib0295) 2011; 208 Shi, Wang, Shen, Jiang, Ge, Li (bib0580) 2017; 36 Guo, Zhao, Cheng, Mu, Kuang, Feng (bib0345) 2017; 7 Zhang, Zhang, Li, Alvarez, Li, Wang (bib0255) 2016; 35 Ma, Zheng, Zhou, Zhang, Chen (bib0200) 2015; 8 Murai, Miyazaki, Nishinakamura, Sugahara, Miyauchi, Sako (bib0350) 2004; 279 Di Leva, Garofalo, Croce (bib0245) 2014; 9 Wang, Chen, Qiao, Kong, Sun, Li (bib0585) 2017; 17 Tian, Pan, Shang, Zhu, Ye, Liu (bib0250) 2014; 289 Schneider, Krämer, Saur (bib0045) 2012; 61 Hou, Li, Yu, Li, Zhang (bib0240) 2016; 13 Kalra, Chaudhary, Yoon, Bhargava, Omar, Garg (bib0395) 2018; 7 Kondo, Ogino, Ogawa, Afroj, Toyoda, Sakaguchi (bib0040) 2018; 25 Chandra Mangalhara, Manvati, Saini, Ponnusamy, Agarwal, Abraham (bib0310) 2017; 391 Xu, Zhu, Zhao, Chen, Zhang, Yuan (bib0325) 2015; 6 Fang (bib0435) 2016; 48 Arteaga, Engelman (bib0455) 2014; 25 Hanrahan, O’Neill, Prencipe, Bugler, Murphy, Fabre (bib0125) 2017; 11 Wu, You, Cheng, Lee, Lin, Hu (bib0555) 2017; 7 Wu, Lin, Cheng, Huang, Wang, Lee (bib0430) 2016; 7 Karihtala, Auvinen, Kauppila, Haapasaari, Jukkola-Vuorinen, Soini (bib0165) 2013; 138 Shibue, Weinberg (bib0105) 2017; 14 Shargh, Sakizl, Khalaj, Movafagh, Yazdi, Hagigatjou (bib0060) 2014; 31 Pickup, Novitskiy, Moses (bib0475) 2013; 13 Larsen, Nathan, Osborne, Farrow, Deb, Sullivan (bib0070) 2016; 126 Zhang, Zhang, Zhang, Zhang, Sun, Xiang (bib0115) 2018; 9 Meidhof, Brabletz, Lehmann, Preca, Mock, Ruh (bib0135) 2015; 7 Zhong, Zheng, Shen, Zhang, Xiong, Zhang (bib0465) 2016; 36 Pieraccioli, Imbastari, Antonov, Melino, Raschellà (bib0265) 2013; 12 Liu, Lu, Huang, Wang, Jiang, Dean (bib0520) 2014; 5 Wu, Li, Tian, Shi, Jiang, Zhang (bib0570) 2018; 1864 Li, Mao, Wang, Su, Mo, Cao (bib0185) 2018; 15 Ye, Wei, Shang, Pan, Yang, Tian (bib0280) 2017; 36 Postigo, Dean (bib0055) 2000; 97 Chen, Gibbons, Goswami, Cortez, Ahn, Byers (bib0270) 2014; 5 Qu, Li, An, Zhao, Zhong, Gu (bib0305) 2015; 47 Chu, Hu, Yu, Tsai, Yu, Wu (bib0080) 2013; 49 Zhang, Guo, Creighton, Lu, Gibbons, Yi (bib0470) 2016; 7 Maturi, Enroth, Heldin, Moustakas (bib0075) 2018; 233 Wu, Fan, Zhang, Ning, Zeng, Zhou (bib0515) 2012; 24 Williams, Montoya, Wu, Eddy, Byers, Shows (bib0050) 1992; 14 Chen, Lu, Montoya-Durango, Liu, Dean, Darling (bib0380) 2017; 7 Harb, Elfeky, El Shafaay, Taha, Osman, Harera (bib0160) 2018 Ebbing, Steins, Fessler, Stathi, Lesterhuis, Krishnadath (bib0460) 2017; 153 Han, Luo, Wang, Chen, Li, Jiang (bib0440) 2016; 11 Roche, Nasarre, Gemmill, Baldys, Pontis, Korch (bib0225) 2013; 5 Lin, Chen, Lin, Chen, Dong (bib0170) 2018; 70 Wang, Huang, Li, Cao, Mo, Jiang (bib0190) 2018 Nishijima, Seike, Soeno, Chiba, Miyanaga, Noro (bib0290) 2016; 48 Nomura, Majumder, Giri, Dauer, Dudeja, Roy (bib0545) 2016; 96 Zhou, Zhang, Hu, Kim, Yao, Xiao (bib0335) 2017; 7 Liao, Jordaan, Srivastava, Dubinett, Sharma, Sharma (bib0220) 2013; 3 Canel, Serrels, Frame, Brunton (bib0010) 2013; 126 Preca, Bajdak, Mock, Sundararajan, Pfannstiel, Maurer (bib0355) 2015; 137 Sahay, Leblanc, Grunewald, Ambatipudi, Ribeiro, Clézardin (bib0150) 2015; 6 Bouillez, Rajabi, Jin, Samur, Tagde, Alam (bib0275) 2017; 36 Siegel, Miller, Jemal (bib0005) 2017; 67 Bae, Choi, Lee, Jo, Lee, Kim (bib0450) 2013; 4 Cong, Du, Zhang, Shen, Su, Pu (bib0400) 2013; 29 Gregory, Bracken, Smith, Bert, Wright, Roslan (bib0490) 2011; 22 Browne, Sayan, Tulchinsky (bib0095) 2010; 9 Zhang, Zhou, Jiang, Liang, Shi, Zhang (bib0230) 2017; 8 Hur, Toiyama, Takahashi, Balaguer, Nagasaka, Koike (bib0340) 2013; 62 Liu, Sánchez-Tilló, Lu, Clem, Telang, Jenson (bib0370) 2013; 4 Ichikawa, Kubota, Nakamura, Weng, Tomida, Saito (bib0215) 2015; 58 Fumarola, Bonelli, Petronini, Alfieri (bib0505) 2014; 90 Liu, Sánchez-Tilló, Lu, Huang, Clem, Telang (bib0375) 2014; 289 Liu, He, Dong, Ma, Wang, Liu (bib0530) 2016; 7 Wang, Ge, Zhang, Chen, Hu, Li (bib0100) 2016; 35 Zhou, Zhang, Guo, Huang, Xie, Yue (bib0260) 2017; 85 Zheng, Carstens, Kim, Scheible, Kaye, Sugimoto (bib0015) 2015; 527 Hugo, Ackland, Blick, Lawrence, Clements, Williams (bib0195) 2007; 213 Wang, Lin, Sun, Fan, Huang, Zhang (bib0535) 2014; 110 Sánchez-Tilló, de Barrios, Siles, Amendola, Darling, Cuatrecasas (bib0420) 2013; 19 Hiendlmeyer, Regus, Wassermann, Hlubek, Haynl, Dimmler (bib0415) 2004; 64 Lazarova, Bordonaro (bib0210) 2017; 8 Schmalhofer, Brabletz, Brabletz (bib0510) 2009; 28 Wang, Chen, Lin, Wang, Cui, Zhang (bib0130) 2017; 51 Su, Luo, Yang, Yang, Yao, Cheng (bib0180) 2016; 76 Tan, Kahata, Idås, Thuault, Heldin, Moustakas (bib0565) 2015; 43 Chaffer, Marjanovic, Lee, Bell, Kleer, Reinhardt (bib0085) 2013; 154 Agajanian, Runa, Kelber (bib0485) 2015; 465 Li, Jin, Yang, Xu, Meng, Deng (bib0145) 2018; 497 Preca, Bajdak, Mock, Lehmann, Sundararajan, Bronsert (bib0360) 2017; 8 Zhang, Sun, Ma (bib0035) 2015; 14 de Barrios, Győrffy, Fernández-Aceñero, Sánchez-Tilló, Sánchez-Moral, Siles (bib0425) 2017; 66 Dupont, Armant, Brenner (bib0205) 2009; 27 Shi, Sawada, Sui, Affar, Whetstine, Lan (bib0065) 2003; 422 Xu, Yang, Lu (bib0500) 2015; 9 Qin, Tang, Hu, Xiao, Xie, Yong (bib0235) 2016; 7 Gu, Li, Shen, Liu, Cao, Jin (bib0540) 2015; 5 Krebs, Mitschke, Lasierra Losada, Schmalhofer, Boerries, Busch (bib0550) 2017; 19 Suzuki, Kawataki, Endo, Miyazawa, Kinouchi, Saitoh (bib0140) 2018; 16 Mishra, K, Kwiatkowski, Sullivan, Sams, Johns (bib0320) 2016; 6 Ahn, Gibbons, Chakravarti, Creighton, Rizvi, Adams (bib0175) 2012; 122 Sánchez-Tilló, de Barrios, Siles, Cuatrecasas, Castells, Postigo (bib0390) 2011; 108 Aghdassi, Sendler, Guenther, Mayerle, Behn, Heidecke (bib0155) 2012; 61 Sintov, Nathan, Knoller, Pasmanik-Chor, Russ, Efrat (bib0365) 2015; 5 Yang, Li, Huang, Xu, Cai, Zhang (bib0405) 2015; 5 Gao, Wang, Luo, Zhang, Xu (bib0495) 2018; 108 Tan, Banerjee, Liu, Yu, Gibbons, Wu (bib0315) 2018; 128 Jung, Fattet, Yang (bib0020) 2015; 21 Singh (10.1016/j.biopha.2018.11.112_bib0025) 2018; 182 Yun (10.1016/j.biopha.2018.11.112_bib0030) 2015; 34 Wang (10.1016/j.biopha.2018.11.112_bib0130) 2017; 51 Gao (10.1016/j.biopha.2018.11.112_bib0495) 2018; 108 Maturi (10.1016/j.biopha.2018.11.112_bib0075) 2018; 233 Shibue (10.1016/j.biopha.2018.11.112_bib0105) 2017; 14 Tan (10.1016/j.biopha.2018.11.112_bib0315) 2018; 128 Li (10.1016/j.biopha.2018.11.112_bib0185) 2018; 15 Han (10.1016/j.biopha.2018.11.112_bib0440) 2016; 11 Chen (10.1016/j.biopha.2018.11.112_bib0270) 2014; 5 Zhang (10.1016/j.biopha.2018.11.112_bib0230) 2017; 8 Liao (10.1016/j.biopha.2018.11.112_bib0220) 2013; 3 Dupont (10.1016/j.biopha.2018.11.112_bib0205) 2009; 27 Wu (10.1016/j.biopha.2018.11.112_bib0570) 2018; 1864 Dong (10.1016/j.biopha.2018.11.112_bib0300) 2013; 32 Wu (10.1016/j.biopha.2018.11.112_bib0430) 2016; 7 Yang (10.1016/j.biopha.2018.11.112_bib0405) 2015; 5 Jägle (10.1016/j.biopha.2018.11.112_bib0560) 2017; 482 Fang (10.1016/j.biopha.2018.11.112_bib0435) 2016; 48 Liu (10.1016/j.biopha.2018.11.112_bib0520) 2014; 5 Zhang (10.1016/j.biopha.2018.11.112_bib0120) 2014; 16 Moon (10.1016/j.biopha.2018.11.112_bib0410) 2015; 22 Postigo (10.1016/j.biopha.2018.11.112_bib0055) 2000; 97 Sintov (10.1016/j.biopha.2018.11.112_bib0365) 2015; 5 Bai (10.1016/j.biopha.2018.11.112_bib0110) 2014; 135 Yang (10.1016/j.biopha.2018.11.112_bib0285) 2014; 124 Shargh (10.1016/j.biopha.2018.11.112_bib0060) 2014; 31 Williams (10.1016/j.biopha.2018.11.112_bib0050) 1992; 14 Chu (10.1016/j.biopha.2018.11.112_bib0080) 2013; 49 Zheng (10.1016/j.biopha.2018.11.112_bib0015) 2015; 527 Li (10.1016/j.biopha.2018.11.112_bib0145) 2018; 497 Roche (10.1016/j.biopha.2018.11.112_bib0225) 2013; 5 Tan (10.1016/j.biopha.2018.11.112_bib0565) 2015; 43 Wang (10.1016/j.biopha.2018.11.112_bib0585) 2017; 17 Hou (10.1016/j.biopha.2018.11.112_bib0240) 2016; 13 Joseph (10.1016/j.biopha.2018.11.112_bib0480) 2014; 5 Canel (10.1016/j.biopha.2018.11.112_bib0010) 2013; 126 Ebbing (10.1016/j.biopha.2018.11.112_bib0460) 2017; 153 Liu (10.1016/j.biopha.2018.11.112_bib0530) 2016; 7 Siegel (10.1016/j.biopha.2018.11.112_bib0005) 2017; 67 Kim (10.1016/j.biopha.2018.11.112_bib0295) 2011; 208 Nomura (10.1016/j.biopha.2018.11.112_bib0545) 2016; 96 Cong (10.1016/j.biopha.2018.11.112_bib0400) 2013; 29 Zhang (10.1016/j.biopha.2018.11.112_bib0255) 2016; 35 Nishijima (10.1016/j.biopha.2018.11.112_bib0290) 2016; 48 Schmalhofer (10.1016/j.biopha.2018.11.112_bib0510) 2009; 28 Sahay (10.1016/j.biopha.2018.11.112_bib0150) 2015; 6 Xu (10.1016/j.biopha.2018.11.112_bib0500) 2015; 9 Wang (10.1016/j.biopha.2018.11.112_bib0535) 2014; 110 Zhang (10.1016/j.biopha.2018.11.112_bib0035) 2015; 14 Zhang (10.1016/j.biopha.2018.11.112_bib0470) 2016; 7 Tian (10.1016/j.biopha.2018.11.112_bib0250) 2014; 289 Richard (10.1016/j.biopha.2018.11.112_bib0445) 2016; 8 Mishra (10.1016/j.biopha.2018.11.112_bib0320) 2016; 6 Gregory (10.1016/j.biopha.2018.11.112_bib0490) 2011; 22 Karihtala (10.1016/j.biopha.2018.11.112_bib0165) 2013; 138 Ye (10.1016/j.biopha.2018.11.112_bib0280) 2017; 36 Preca (10.1016/j.biopha.2018.11.112_bib0360) 2017; 8 Hugo (10.1016/j.biopha.2018.11.112_bib0195) 2007; 213 Pickup (10.1016/j.biopha.2018.11.112_bib0475) 2013; 13 Jung (10.1016/j.biopha.2018.11.112_bib0020) 2015; 21 Zhou (10.1016/j.biopha.2018.11.112_bib0335) 2017; 7 Liu (10.1016/j.biopha.2018.11.112_bib0385) 2009; 4 Lazarova (10.1016/j.biopha.2018.11.112_bib0210) 2017; 8 Di Leva (10.1016/j.biopha.2018.11.112_bib0245) 2014; 9 Hur (10.1016/j.biopha.2018.11.112_bib0340) 2013; 62 Krebs (10.1016/j.biopha.2018.11.112_bib0550) 2017; 19 Chen (10.1016/j.biopha.2018.11.112_bib0380) 2017; 7 Xu (10.1016/j.biopha.2018.11.112_bib0325) 2015; 6 Liu (10.1016/j.biopha.2018.11.112_bib0375) 2014; 289 Pan (10.1016/j.biopha.2018.11.112_bib0525) 2016; 7 Harb (10.1016/j.biopha.2018.11.112_bib0160) 2018 Ma (10.1016/j.biopha.2018.11.112_bib0200) 2015; 8 Guo (10.1016/j.biopha.2018.11.112_bib0345) 2017; 7 Chaffer (10.1016/j.biopha.2018.11.112_bib0085) 2013; 154 Wang (10.1016/j.biopha.2018.11.112_bib0100) 2016; 35 Chen (10.1016/j.biopha.2018.11.112_bib0330) 2015; 6 Qin (10.1016/j.biopha.2018.11.112_bib0235) 2016; 7 Qu (10.1016/j.biopha.2018.11.112_bib0305) 2015; 47 Li (10.1016/j.biopha.2018.11.112_bib0575) 2017; 129 Zhang (10.1016/j.biopha.2018.11.112_bib0115) 2018; 9 Pieraccioli (10.1016/j.biopha.2018.11.112_bib0265) 2013; 12 Shi (10.1016/j.biopha.2018.11.112_bib0580) 2017; 36 Chandra Mangalhara (10.1016/j.biopha.2018.11.112_bib0310) 2017; 391 Su (10.1016/j.biopha.2018.11.112_bib0180) 2016; 76 Lin (10.1016/j.biopha.2018.11.112_bib0170) 2018; 70 Zhong (10.1016/j.biopha.2018.11.112_bib0465) 2016; 36 Wang (10.1016/j.biopha.2018.11.112_bib0190) 2018 Aghdassi (10.1016/j.biopha.2018.11.112_bib0155) 2012; 61 Hiendlmeyer (10.1016/j.biopha.2018.11.112_bib0415) 2004; 64 Wu (10.1016/j.biopha.2018.11.112_bib0515) 2012; 24 Sánchez-Tilló (10.1016/j.biopha.2018.11.112_bib0390) 2011; 108 de Barrios (10.1016/j.biopha.2018.11.112_bib0425) 2017; 66 Kondo (10.1016/j.biopha.2018.11.112_bib0040) 2018; 25 Ahn (10.1016/j.biopha.2018.11.112_bib0175) 2012; 122 Bae (10.1016/j.biopha.2018.11.112_bib0450) 2013; 4 Hanrahan (10.1016/j.biopha.2018.11.112_bib0125) 2017; 11 Shi (10.1016/j.biopha.2018.11.112_bib0065) 2003; 422 Larsen (10.1016/j.biopha.2018.11.112_bib0070) 2016; 126 Gu (10.1016/j.biopha.2018.11.112_bib0540) 2015; 5 Bouillez (10.1016/j.biopha.2018.11.112_bib0275) 2017; 36 Wu (10.1016/j.biopha.2018.11.112_bib0555) 2017; 7 Suzuki (10.1016/j.biopha.2018.11.112_bib0140) 2018; 16 Agajanian (10.1016/j.biopha.2018.11.112_bib0485) 2015; 465 Zhou (10.1016/j.biopha.2018.11.112_bib0260) 2017; 85 Preca (10.1016/j.biopha.2018.11.112_bib0355) 2015; 137 Gao (10.1016/j.biopha.2018.11.112_bib0090) 2016; 6 Fumarola (10.1016/j.biopha.2018.11.112_bib0505) 2014; 90 Kalra (10.1016/j.biopha.2018.11.112_bib0395) 2018; 7 Sánchez-Tilló (10.1016/j.biopha.2018.11.112_bib0420) 2013; 19 Arteaga (10.1016/j.biopha.2018.11.112_bib0455) 2014; 25 Schneider (10.1016/j.biopha.2018.11.112_bib0045) 2012; 61 Browne (10.1016/j.biopha.2018.11.112_bib0095) 2010; 9 Ichikawa (10.1016/j.biopha.2018.11.112_bib0215) 2015; 58 Meidhof (10.1016/j.biopha.2018.11.112_bib0135) 2015; 7 Liu (10.1016/j.biopha.2018.11.112_bib0370) 2013; 4 Murai (10.1016/j.biopha.2018.11.112_bib0350) 2004; 279 |
| References_xml | – volume: 8 start-page: e2732 year: 2017 ident: bib0230 article-title: ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer publication-title: Cell Death Dis. – volume: 5 start-page: 1169 year: 2015 end-page: 1179 ident: bib0540 article-title: Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-κB/ZEB1 signal pathway publication-title: Am. J. Cancer Res. – volume: 128 start-page: 1267 year: 2018 end-page: 1282 ident: bib0315 article-title: The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network publication-title: J. Clin. Invest. – volume: 7 start-page: 45 year: 2017 ident: bib0380 article-title: ZEB1 regulates multiple oncogenic components involved in uveal melanoma progression publication-title: Sci. Rep. – volume: 8 start-page: 11530 year: 2017 end-page: 11543 ident: bib0360 article-title: A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer publication-title: Oncotarget – volume: 4 start-page: 336 year: 2009 end-page: 347 ident: bib0385 article-title: Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype publication-title: Cell Stem Cell – volume: 13 start-page: 788 year: 2013 end-page: 799 ident: bib0475 article-title: The roles of TGFβ in the tumour microenvironment publication-title: Nat. Rev. Cancer – volume: 36 start-page: 2577 year: 2017 end-page: 2588 ident: bib0580 article-title: Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling publication-title: Oncogene – volume: 13 start-page: 1681 year: 2016 end-page: 1688 ident: bib0240 article-title: SET8 induces epithelial-mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1 publication-title: Mol. Med. Rep. – volume: 208 start-page: 875 year: 2011 end-page: 883 ident: bib0295 article-title: p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2 publication-title: J. Exp. Med. – volume: 61 start-page: 329 year: 2012 end-page: 330 ident: bib0045 article-title: A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer publication-title: Gut – volume: 126 start-page: 3219 year: 2016 end-page: 3235 ident: bib0070 article-title: ZEB1 drives epithelial-to-mesenchymal transition in lung cancer publication-title: J. Clin. Invest. – volume: 49 start-page: 34 year: 2013 end-page: 41 ident: bib0080 article-title: Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer publication-title: Oral Oncol. – volume: 5 start-page: e1443 year: 2014 ident: bib0480 article-title: TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion publication-title: Cell Death Dis. – volume: 51 start-page: 1239 year: 2017 end-page: 1248 ident: bib0130 article-title: Novel crosstalk between KLF4 and ZEB1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma publication-title: Int. J. Oncol. – volume: 62 start-page: 1315 year: 2013 end-page: 1326 ident: bib0340 article-title: MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis publication-title: Gut – volume: 137 start-page: 2566 year: 2015 end-page: 2577 ident: bib0355 article-title: A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells publication-title: Int. J. Cancer – volume: 35 start-page: 53 year: 2016 ident: bib0100 article-title: Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis publication-title: J. Exp. Clin. Cancer Res. – volume: 61 start-page: 439 year: 2012 end-page: 448 ident: bib0155 article-title: Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer publication-title: Gut – volume: 67 start-page: 7 year: 2017 end-page: 30 ident: bib0005 article-title: Cancer Statistics, 2017 publication-title: CA Cancer J. Clin. – volume: 5 start-page: 334 year: 2013 end-page: 356 ident: bib0225 article-title: Global decrease of histone H3K27 acetylation in ZEB1-Induced epithelial to mesenchymal transition in lung Cancer cells publication-title: Cancers (Basel) – year: 2018 ident: bib0160 article-title: SPOP, ZEB-1 and E-cadherin expression in clear cell renal cell carcinoma (cc-RCC): clinicopathological and prognostic significance publication-title: Pathophysiology – volume: 129 start-page: 497 year: 2017 end-page: 508 ident: bib0575 article-title: The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia publication-title: Blood – volume: 47 start-page: 2141 year: 2015 end-page: 2152 ident: bib0305 article-title: MicroRNA-33b inhibits lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/β-catenin/ZEB1 signaling publication-title: Int. J. Oncol. – volume: 6 start-page: 20604 year: 2015 end-page: 20620 ident: bib0150 article-title: The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer publication-title: Oncotarget – volume: 16 start-page: 864 year: 2014 end-page: 875 ident: bib0120 article-title: ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1 publication-title: Nat. Cell Biol. – volume: 90 start-page: 197 year: 2014 end-page: 207 ident: bib0505 article-title: Targeting PI3K/AKT /mTOR pathway in non small cell lung cancer publication-title: Biochem. Pharmacol. – volume: 7 start-page: 351 year: 2016 end-page: 361 ident: bib0235 article-title: An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to- mesenchymal transition (EMT) in colorectal cancer publication-title: Oncotarget – volume: 32 start-page: 3286 year: 2013 end-page: 3295 ident: bib0300 article-title: Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis publication-title: Oncogene – volume: 233 start-page: 7113 year: 2018 end-page: 7127 ident: bib0075 article-title: Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells publication-title: J. Cell. Physiol. – volume: 126 start-page: 393 year: 2013 end-page: 401 ident: bib0010 article-title: E-cadherin-integrin crosstalk in cancer invasion and metastasis publication-title: J. Cell. Sci. – volume: 279 start-page: 4541 year: 2004 end-page: 4550 ident: bib0350 article-title: Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration publication-title: J. Biol. Chem. – volume: 6 start-page: 862 year: 2015 end-page: 873 ident: bib0330 article-title: The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer publication-title: Oncotarget – volume: 5 start-page: 13024 year: 2015 ident: bib0365 article-title: Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro publication-title: Sci. Rep. – volume: 108 start-page: 19204 year: 2011 end-page: 19209 ident: bib0390 article-title: β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 48 start-page: 27 year: 2016 end-page: 38 ident: bib0435 article-title: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies, Acta Biochim publication-title: Biophys. Sin. (Shanghai) – volume: 7 start-page: 12231 year: 2016 ident: bib0470 article-title: A genetic cell context-dependent role for ZEB1 in lung cancer publication-title: Nat. Commun. – volume: 110 start-page: 695 year: 2014 end-page: 705 ident: bib0535 article-title: Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma publication-title: Br. J. Cancer – volume: 43 start-page: 162 year: 2015 end-page: 178 ident: bib0565 article-title: The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition publication-title: Nucleic Acids Res. – volume: 7 start-page: 39 year: 2018 ident: bib0395 article-title: CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target publication-title: Oncogenesis – volume: 19 start-page: 1071 year: 2013 end-page: 1082 ident: bib0420 article-title: ZEB1 promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1 publication-title: Clin. Cancer Res. – volume: 213 start-page: 374 year: 2007 end-page: 383 ident: bib0195 article-title: Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression publication-title: J. Cell. Physiol. – volume: 35 start-page: 5641 year: 2016 end-page: 5652 ident: bib0255 article-title: SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans publication-title: Oncogene – volume: 9 start-page: 317 year: 2015 end-page: 324 ident: bib0500 article-title: A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition publication-title: Cell Adh. Migr. – volume: 66 start-page: 666 year: 2017 end-page: 682 ident: bib0425 article-title: ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1 publication-title: Gut – volume: 1864 start-page: 2511 year: 2018 end-page: 2525 ident: bib0570 article-title: Epigenetic dysregulation of ZEB1 is involved in LMO2-promoted T-cell acute lymphoblastic leukaemia leukaemogenesis publication-title: Biochim. Biophys. Acta – volume: 124 start-page: 2696 year: 2014 end-page: 2708 ident: bib0285 article-title: ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism publication-title: J. Clin. Invest. – volume: 482 start-page: 1226 year: 2017 end-page: 1232 ident: bib0560 article-title: ZEB1 is neither sufficient nor required for epithelial- mesenchymal transition in LS174T colorectal cancer cells publication-title: Biochem. Biophys. Res. Commun. – volume: 153 start-page: 63 year: 2017 end-page: 76 ident: bib0460 article-title: Esophageal adenocarcinoma cells and xenograft tumors exposed to Erb-b2 receptor tyrosine kinase 2 and 3 inhibitors activate transforming growth factor beta signaling, which induces epithelial to mesenchymal transition publication-title: Gastroenterology – volume: 122 start-page: 3170 year: 2012 end-page: 3183 ident: bib0175 article-title: ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression publication-title: J. Clin. Invest. – volume: 28 start-page: 151 year: 2009 end-page: 166 ident: bib0510 article-title: E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer publication-title: Cancer Metastasis Rev. – volume: 182 start-page: 80 year: 2018 end-page: 94 ident: bib0025 article-title: EMT: mechanisms and therapeutic implications publication-title: Pharmacol. Ther. – volume: 9 start-page: 886 year: 2010 end-page: 891 ident: bib0095 article-title: ZEB proteins link cell motility with cell cycle control and cell survival in cancer publication-title: Cell Cycle – volume: 22 start-page: 1341 year: 2015 end-page: 1352 ident: bib0410 article-title: LAMC2 enhances the metastatic potential of lung adenocarcinoma publication-title: Cell Death Differ. – volume: 58 start-page: 35 year: 2015 end-page: 46 ident: bib0215 article-title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP publication-title: Mol. Cell – volume: 36 start-page: 4037 year: 2017 end-page: 4046 ident: bib0275 article-title: MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small cell lung cancer publication-title: Oncogene – volume: 135 start-page: 1356 year: 2014 end-page: 1368 ident: bib0110 article-title: MiR-200c suppresses TGF-β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer publication-title: Int. J. Cancer – volume: 29 start-page: 1579 year: 2013 end-page: 1587 ident: bib0400 article-title: Downregulated microRNA-200a promotes EMT and tumor growth through the Wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma publication-title: Oncol. Rep. – volume: 34 start-page: 2741 year: 2015 end-page: 2752 ident: bib0030 article-title: DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1 publication-title: Oncogene – volume: 11 start-page: 251 year: 2017 end-page: 265 ident: bib0125 article-title: The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer publication-title: Mol. Oncol. – volume: 4 start-page: 2512 year: 2013 end-page: 2522 ident: bib0450 article-title: Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer publication-title: Oncotarget – volume: 5 start-page: 748 year: 2015 end-page: 755 ident: bib0405 article-title: Wnt signaling through Snail1 and ZEB1 regulates bone metastasis in lung cancer publication-title: Am. J. Cancer Res. – volume: 7 start-page: 2020 year: 2017 end-page: 2031 ident: bib0335 article-title: USP51 promotes deubiquitination and stabilization of ZEB1 publication-title: Am. J. Cancer Res. – volume: 138 start-page: 81 year: 2013 end-page: 90 ident: bib0165 article-title: Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype publication-title: Breast Cancer Res. Treat. – volume: 7 start-page: 831 year: 2015 end-page: 847 ident: bib0135 article-title: ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat publication-title: EMBO Mol. Med. – volume: 289 start-page: 36101 year: 2014 end-page: 36115 ident: bib0250 article-title: MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells publication-title: J. Biol. Chem. – volume: 15 start-page: 5193 year: 2018 end-page: 5200 ident: bib0185 article-title: Vasculogenic mimicry in bladder cancer and its association with the aberrant expression of ZEB1 publication-title: Oncol. Lett. – volume: 48 start-page: 937 year: 2016 end-page: 944 ident: bib0290 article-title: miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells publication-title: Int. J. Oncol. – volume: 14 start-page: 611 year: 2017 end-page: 629 ident: bib0105 article-title: EMT, CSCs, and drug resistance: the mechanistic link and clinical implications publication-title: Nat. Rev. Clin. Oncol. – volume: 3 start-page: 374 year: 2013 end-page: 389 ident: bib0220 article-title: Effect of epigenetic histone modifications on E-cadherin splicing and expression in lung cancer publication-title: Am. J. Cancer Res. – volume: 12 start-page: 2309 year: 2013 end-page: 2320 ident: bib0265 article-title: Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation publication-title: Cell Cycle – year: 2018 ident: bib0190 article-title: ZEB1-mediated vasculogenic mimicry formation associates with epithelial-mesenchymal transition and cancer stem cell phenotypes in prostate cancer publication-title: J. Cell. Mol. Med. – volume: 25 start-page: 119 year: 2018 end-page: 121 ident: bib0040 article-title: A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial- mesenchymal transition publication-title: Respir. Med. Case Rep. – volume: 391 start-page: 59 year: 2017 end-page: 73 ident: bib0310 article-title: ERK2-ZEB1-miR-101-1 axis contributes to epithelial-mesenchymal transition and cell migration in cancer publication-title: Cancer Lett. – volume: 22 start-page: 1686 year: 2011 end-page: 1698 ident: bib0490 article-title: An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial- mesenchymal transition publication-title: Mol. Biol. Cell – volume: 19 start-page: 518 year: 2017 end-page: 529 ident: bib0550 article-title: The EMT-activator ZEB1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer publication-title: Nat. Cell Biol. – volume: 422 start-page: 735 year: 2003 end-page: 738 ident: bib0065 article-title: Coordinated histone modifications mediated by a CtBP co-repressor complex publication-title: Nature – volume: 154 start-page: 61 year: 2013 end-page: 74 ident: bib0085 article-title: Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity publication-title: Cell – volume: 14 start-page: 481 year: 2015 end-page: 487 ident: bib0035 article-title: ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance publication-title: Cell Cycle – volume: 108 start-page: 27 year: 2018 end-page: 35 ident: bib0495 article-title: miR-217 represses TGF-β1-induced airway smooth muscle cell proliferation and migration through targeting ZEB1 publication-title: Biomed. Pharmacother. – volume: 8 start-page: 11258 year: 2015 end-page: 11267 ident: bib0200 article-title: ZEB1 promotes the progression and metastasis of cervical squamous cell carcinoma via the promotion of epithelial-mesenchymal transition publication-title: Int. J. Clin. Exp. Pathol. – volume: 36 start-page: 2742 year: 2016 end-page: 2754 ident: bib0465 article-title: Suppression of MicroRNA 200 family expression by oncogenic KRAS activation promotes cell survival and epithelial-mesenchymal transition in KRAS-driven cancer publication-title: Mol. Cell. Biol. – volume: 527 start-page: 525 year: 2015 end-page: 530 ident: bib0015 article-title: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer publication-title: Nature – volume: 31 start-page: 250 year: 2014 ident: bib0060 article-title: Downregulation of E-cadherin expression in breast cancer by promoter hypermethylation and its relation with progression and prognosis of tumor publication-title: Med. Oncol. – volume: 6 start-page: 979 year: 2015 end-page: 994 ident: bib0325 article-title: Atypical ubiquitin E3 ligase complex Skp1-Pam- Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors publication-title: Oncotarget – volume: 7 start-page: 22687 year: 2016 end-page: 22699 ident: bib0430 article-title: DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the β-catenin/ZEB1 axis publication-title: Oncotarget – volume: 7 start-page: 17753 year: 2017 ident: bib0555 article-title: Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1 publication-title: Sci. Rep. – volume: 36 start-page: 6391 year: 2017 end-page: 6407 ident: bib0280 article-title: Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity publication-title: Oncogene – volume: 7 start-page: 49948 year: 2016 end-page: 49960 ident: bib0525 article-title: Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer publication-title: Oncotarget – volume: 85 start-page: 113 year: 2017 end-page: 119 ident: bib0260 article-title: miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K/Akt signaling pathway and inhibits cell migration via targeting ZEB1 publication-title: Biomed. Pharmacother. – volume: 8 start-page: 1453 year: 2017 end-page: 1459 ident: bib0210 article-title: ZEB1 mediates drug resistance and EMT in p300-deficient CRC publication-title: J. Cancer – volume: 16 start-page: 1758 year: 2018 end-page: 1764 ident: bib0140 article-title: Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade publication-title: Oncol. Lett. – volume: 14 start-page: 194 year: 1992 end-page: 196 ident: bib0050 article-title: The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2 publication-title: Genomics – volume: 27 start-page: 351 year: 2009 end-page: 357 ident: bib0205 article-title: Epigenetics: definition, mechanisms and clinical perspective publication-title: Semin. Reprod. Med. – volume: 64 start-page: 1209 year: 2004 end-page: 1214 ident: bib0415 article-title: Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors publication-title: Cancer Res. – volume: 497 start-page: 633 year: 2018 end-page: 638 ident: bib0145 article-title: GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma publication-title: Biochem. Biophys. Res. Commun. – volume: 5 start-page: 5241 year: 2014 ident: bib0270 article-title: Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression publication-title: Nat. Commun. – volume: 70 start-page: 1032 year: 2018 end-page: 1039 ident: bib0170 article-title: Overexpressing PRMT1 inhibits proliferation and invasion in pancreatic cancer by inverse correlation of ZEB1 publication-title: IUBMB Life – volume: 8 start-page: 1143 year: 2016 end-page: 1161 ident: bib0445 article-title: ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors publication-title: EMBO Mol. Med. – volume: 25 start-page: 282 year: 2014 end-page: 303 ident: bib0455 article-title: ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics publication-title: Cancer Cell – volume: 11 start-page: 753 year: 2016 end-page: 759 ident: bib0440 article-title: Hepatocyte growth factor increases the invasive potential of PC-3 human prostate cancer cells via an ERK/MAPK and Zeb-1 signaling pathway publication-title: Oncol. Lett. – volume: 24 start-page: 2273 year: 2012 end-page: 2282 ident: bib0515 article-title: PI3K/Akt to GSK3β/β-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription publication-title: Cell. Signal. – volume: 5 start-page: 5660 year: 2014 ident: bib0520 article-title: Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis publication-title: Nat. Commun. – volume: 6 start-page: 19874 year: 2016 ident: bib0090 article-title: The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1 publication-title: Sci. Rep. – volume: 76 start-page: 5054 year: 2016 end-page: 5067 ident: bib0180 article-title: MEF2D transduces microenvironment stimuli to ZEB1 to promote epithelial-mesenchymal transition and metastasis in colorectal cancer publication-title: Cancer Res. – volume: 7 start-page: 75210 year: 2016 end-page: 75220 ident: bib0530 article-title: Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway publication-title: Oncotarget – volume: 9 start-page: 287 year: 2014 end-page: 314 ident: bib0245 article-title: MicroRNAs in cancer publication-title: Annu. Rev. Pathol. – volume: 6 start-page: 986 year: 2016 end-page: 1005 ident: bib0320 article-title: Mechanism, consequences, and therapeutic targeting of abnormal IL15 signaling in cutaneous T-cell lymphoma publication-title: Cancer Discov. – volume: 9 start-page: 57 year: 2018 ident: bib0115 article-title: ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM publication-title: Cell Death Dis. – volume: 21 start-page: 962 year: 2015 end-page: 968 ident: bib0020 article-title: Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis publication-title: Clin. Cancer Res. – volume: 97 start-page: 6391 year: 2000 end-page: 6396 ident: bib0055 article-title: Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 96 start-page: 1268 year: 2016 end-page: 1278 ident: bib0545 article-title: Inhibition of NF-kappa B pathway leads to deregulation of epithelial-mesenchymal transition and neural invasion in pancreatic cancer publication-title: Lab. Invest. – volume: 17 start-page: 719 year: 2017 ident: bib0585 article-title: Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer publication-title: BMC Cancer – volume: 4 start-page: 2650 year: 2013 ident: bib0370 article-title: Rb1 family mutation is sufficient for sarcoma initiation publication-title: Nat. Commun. – volume: 7 start-page: 2234 year: 2017 end-page: 2244 ident: bib0345 article-title: AKIP1 promoted epithelial-mesenchymal transition of non-small-cell lung cancer via transactivating ZEB1 publication-title: Am. J. Cancer Res. – volume: 289 start-page: 4116 year: 2014 end-page: 4125 ident: bib0375 article-title: The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression publication-title: J. Biol. Chem. – volume: 465 start-page: 606 year: 2015 end-page: 612 ident: bib0485 article-title: Identification of a PEAK1/ZEB1 signaling axis during TGF /fibronectin-induced EMT in breast cancer publication-title: Biochem. Biophys. Res. Commun. – volume: 28 start-page: 151 year: 2009 ident: 10.1016/j.biopha.2018.11.112_bib0510 article-title: E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-008-9179-y – volume: 12 start-page: 2309 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0265 article-title: Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation publication-title: Cell Cycle doi: 10.4161/cc.25405 – volume: 5 start-page: 1169 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0540 article-title: Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-κB/ZEB1 signal pathway publication-title: Am. J. Cancer Res. – volume: 9 start-page: 57 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0115 article-title: ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM publication-title: Cell Death Dis. doi: 10.1038/s41419-017-0087-3 – volume: 61 start-page: 439 year: 2012 ident: 10.1016/j.biopha.2018.11.112_bib0155 article-title: Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer publication-title: Gut doi: 10.1136/gutjnl-2011-300060 – volume: 135 start-page: 1356 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0110 article-title: MiR-200c suppresses TGF-β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer publication-title: Int. J. Cancer doi: 10.1002/ijc.28782 – volume: 48 start-page: 27 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0435 article-title: RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies, Acta Biochim publication-title: Biophys. Sin. (Shanghai) doi: 10.1093/abbs/gmv090 – volume: 7 start-page: 22687 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0430 article-title: DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the β-catenin/ZEB1 axis publication-title: Oncotarget doi: 10.18632/oncotarget.8143 – volume: 8 start-page: 11530 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0360 article-title: A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer publication-title: Oncotarget doi: 10.18632/oncotarget.14563 – volume: 16 start-page: 1758 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0140 article-title: Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade publication-title: Oncol. Lett. – volume: 8 start-page: 1143 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0445 article-title: ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201505971 – volume: 7 start-page: 45 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0380 article-title: ZEB1 regulates multiple oncogenic components involved in uveal melanoma progression publication-title: Sci. Rep. doi: 10.1038/s41598-017-00079-x – volume: 61 start-page: 329 year: 2012 ident: 10.1016/j.biopha.2018.11.112_bib0045 article-title: A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer publication-title: Gut doi: 10.1136/gutjnl-2011-301576 – volume: 97 start-page: 6391 year: 2000 ident: 10.1016/j.biopha.2018.11.112_bib0055 article-title: Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.97.12.6391 – volume: 47 start-page: 2141 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0305 article-title: MicroRNA-33b inhibits lung adenocarcinoma cell growth, invasion, and epithelial-mesenchymal transition by suppressing Wnt/β-catenin/ZEB1 signaling publication-title: Int. J. Oncol. doi: 10.3892/ijo.2015.3187 – volume: 6 start-page: 979 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0325 article-title: Atypical ubiquitin E3 ligase complex Skp1-Pam- Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors publication-title: Oncotarget doi: 10.18632/oncotarget.2825 – volume: 66 start-page: 666 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0425 article-title: ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1 publication-title: Gut doi: 10.1136/gutjnl-2015-310838 – volume: 9 start-page: 886 year: 2010 ident: 10.1016/j.biopha.2018.11.112_bib0095 article-title: ZEB proteins link cell motility with cell cycle control and cell survival in cancer publication-title: Cell Cycle doi: 10.4161/cc.9.5.10839 – volume: 48 start-page: 937 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0290 article-title: miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells publication-title: Int. J. Oncol. doi: 10.3892/ijo.2016.3331 – volume: 128 start-page: 1267 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0315 article-title: The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network publication-title: J. Clin. Invest. doi: 10.1172/JCI97225 – volume: 7 start-page: 351 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0235 article-title: An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to- mesenchymal transition (EMT) in colorectal cancer publication-title: Oncotarget doi: 10.18632/oncotarget.5968 – volume: 482 start-page: 1226 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0560 article-title: ZEB1 is neither sufficient nor required for epithelial- mesenchymal transition in LS174T colorectal cancer cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2016.12.017 – volume: 90 start-page: 197 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0505 article-title: Targeting PI3K/AKT /mTOR pathway in non small cell lung cancer publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2014.05.011 – volume: 153 start-page: 63 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0460 article-title: Esophageal adenocarcinoma cells and xenograft tumors exposed to Erb-b2 receptor tyrosine kinase 2 and 3 inhibitors activate transforming growth factor beta signaling, which induces epithelial to mesenchymal transition publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.03.004 – volume: 7 start-page: 12231 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0470 article-title: A genetic cell context-dependent role for ZEB1 in lung cancer publication-title: Nat. Commun. doi: 10.1038/ncomms12231 – volume: 32 start-page: 3286 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0300 article-title: Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis publication-title: Oncogene doi: 10.1038/onc.2012.334 – volume: 6 start-page: 862 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0330 article-title: The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer publication-title: Oncotarget doi: 10.18632/oncotarget.2696 – volume: 35 start-page: 5641 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0255 article-title: SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans publication-title: Oncogene doi: 10.1038/onc.2016.100 – year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0160 article-title: SPOP, ZEB-1 and E-cadherin expression in clear cell renal cell carcinoma (cc-RCC): clinicopathological and prognostic significance publication-title: Pathophysiology doi: 10.1016/j.pathophys.2018.05.004 – volume: 36 start-page: 2577 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0580 article-title: Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling publication-title: Oncogene doi: 10.1038/onc.2016.414 – volume: 49 start-page: 34 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0080 article-title: Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer publication-title: Oral Oncol. doi: 10.1016/j.oraloncology.2012.07.012 – volume: 122 start-page: 3170 year: 2012 ident: 10.1016/j.biopha.2018.11.112_bib0175 article-title: ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression publication-title: J. Clin. Invest. doi: 10.1172/JCI63608 – volume: 27 start-page: 351 year: 2009 ident: 10.1016/j.biopha.2018.11.112_bib0205 article-title: Epigenetics: definition, mechanisms and clinical perspective publication-title: Semin. Reprod. Med. doi: 10.1055/s-0029-1237423 – volume: 465 start-page: 606 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0485 article-title: Identification of a PEAK1/ZEB1 signaling axis during TGF /fibronectin-induced EMT in breast cancer publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2015.08.071 – volume: 108 start-page: 27 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0495 article-title: miR-217 represses TGF-β1-induced airway smooth muscle cell proliferation and migration through targeting ZEB1 publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2018.09.030 – volume: 289 start-page: 36101 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0250 article-title: MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.598383 – volume: 22 start-page: 1341 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0410 article-title: LAMC2 enhances the metastatic potential of lung adenocarcinoma publication-title: Cell Death Differ. doi: 10.1038/cdd.2014.228 – volume: 7 start-page: 2234 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0345 article-title: AKIP1 promoted epithelial-mesenchymal transition of non-small-cell lung cancer via transactivating ZEB1 publication-title: Am. J. Cancer Res. – volume: 6 start-page: 986 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0320 article-title: Mechanism, consequences, and therapeutic targeting of abnormal IL15 signaling in cutaneous T-cell lymphoma publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-15-1297 – volume: 110 start-page: 695 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0535 article-title: Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma publication-title: Br. J. Cancer doi: 10.1038/bjc.2013.770 – volume: 14 start-page: 481 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0035 article-title: ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance publication-title: Cell Cycle doi: 10.1080/15384101.2015.1006048 – volume: 76 start-page: 5054 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0180 article-title: MEF2D transduces microenvironment stimuli to ZEB1 to promote epithelial-mesenchymal transition and metastasis in colorectal cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-0246 – volume: 19 start-page: 518 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0550 article-title: The EMT-activator ZEB1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer publication-title: Nat. Cell Biol. doi: 10.1038/ncb3513 – volume: 21 start-page: 962 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0020 article-title: Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-13-3173 – volume: 34 start-page: 2741 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0030 article-title: DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1 publication-title: Oncogene doi: 10.1038/onc.2014.215 – volume: 9 start-page: 287 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0245 article-title: MicroRNAs in cancer publication-title: Annu. Rev. Pathol. doi: 10.1146/annurev-pathol-012513-104715 – volume: 7 start-page: 17753 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0555 article-title: Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1 publication-title: Sci. Rep. doi: 10.1038/s41598-017-18101-7 – volume: 422 start-page: 735 year: 2003 ident: 10.1016/j.biopha.2018.11.112_bib0065 article-title: Coordinated histone modifications mediated by a CtBP co-repressor complex publication-title: Nature doi: 10.1038/nature01550 – volume: 6 start-page: 20604 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0150 article-title: The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer publication-title: Oncotarget doi: 10.18632/oncotarget.3774 – volume: 7 start-page: 831 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0135 article-title: ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201404396 – volume: 11 start-page: 251 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0125 article-title: The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer publication-title: Mol. Oncol. doi: 10.1002/1878-0261.12030 – volume: 85 start-page: 113 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0260 article-title: miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K/Akt signaling pathway and inhibits cell migration via targeting ZEB1 publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2016.11.100 – volume: 22 start-page: 1686 year: 2011 ident: 10.1016/j.biopha.2018.11.112_bib0490 article-title: An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial- mesenchymal transition publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e11-02-0103 – volume: 9 start-page: 317 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0500 article-title: A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition publication-title: Cell Adh. Migr. doi: 10.1080/19336918.2015.1016686 – volume: 527 start-page: 525 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0015 article-title: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer publication-title: Nature doi: 10.1038/nature16064 – year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0190 article-title: ZEB1-mediated vasculogenic mimicry formation associates with epithelial-mesenchymal transition and cancer stem cell phenotypes in prostate cancer publication-title: J. Cell. Mol. Med. – volume: 154 start-page: 61 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0085 article-title: Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity publication-title: Cell doi: 10.1016/j.cell.2013.06.005 – volume: 67 start-page: 7 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0005 article-title: Cancer Statistics, 2017 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21387 – volume: 58 start-page: 35 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0215 article-title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.01.023 – volume: 5 start-page: 5660 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0520 article-title: Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis publication-title: Nat. Commun. doi: 10.1038/ncomms6660 – volume: 15 start-page: 5193 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0185 article-title: Vasculogenic mimicry in bladder cancer and its association with the aberrant expression of ZEB1 publication-title: Oncol. Lett. – volume: 5 start-page: 5241 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0270 article-title: Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression publication-title: Nat. Commun. doi: 10.1038/ncomms6241 – volume: 51 start-page: 1239 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0130 article-title: Novel crosstalk between KLF4 and ZEB1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma publication-title: Int. J. Oncol. doi: 10.3892/ijo.2017.4099 – volume: 43 start-page: 162 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0565 article-title: The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1293 – volume: 7 start-page: 39 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0395 article-title: CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target publication-title: Oncogenesis doi: 10.1038/s41389-018-0048-4 – volume: 7 start-page: 75210 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0530 article-title: Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway publication-title: Oncotarget doi: 10.18632/oncotarget.12116 – volume: 279 start-page: 4541 year: 2004 ident: 10.1016/j.biopha.2018.11.112_bib0350 article-title: Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration publication-title: J. Biol. Chem. doi: 10.1074/jbc.M307356200 – volume: 14 start-page: 611 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0105 article-title: EMT, CSCs, and drug resistance: the mechanistic link and clinical implications publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2017.44 – volume: 126 start-page: 3219 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0070 article-title: ZEB1 drives epithelial-to-mesenchymal transition in lung cancer publication-title: J. Clin. Invest. doi: 10.1172/JCI76725 – volume: 19 start-page: 1071 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0420 article-title: ZEB1 promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-2675 – volume: 8 start-page: 11258 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0200 article-title: ZEB1 promotes the progression and metastasis of cervical squamous cell carcinoma via the promotion of epithelial-mesenchymal transition publication-title: Int. J. Clin. Exp. Pathol. – volume: 3 start-page: 374 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0220 article-title: Effect of epigenetic histone modifications on E-cadherin splicing and expression in lung cancer publication-title: Am. J. Cancer Res. – volume: 36 start-page: 6391 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0280 article-title: Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity publication-title: Oncogene doi: 10.1038/onc.2017.241 – volume: 108 start-page: 19204 year: 2011 ident: 10.1016/j.biopha.2018.11.112_bib0390 article-title: β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1108977108 – volume: 64 start-page: 1209 year: 2004 ident: 10.1016/j.biopha.2018.11.112_bib0415 article-title: Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-3627-2 – volume: 24 start-page: 2273 year: 2012 ident: 10.1016/j.biopha.2018.11.112_bib0515 article-title: PI3K/Akt to GSK3β/β-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2012.08.004 – volume: 11 start-page: 753 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0440 article-title: Hepatocyte growth factor increases the invasive potential of PC-3 human prostate cancer cells via an ERK/MAPK and Zeb-1 signaling pathway publication-title: Oncol. Lett. doi: 10.3892/ol.2015.3943 – volume: 497 start-page: 633 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0145 article-title: GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2018.02.120 – volume: 5 start-page: e1443 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0480 article-title: TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion publication-title: Cell Death Dis. doi: 10.1038/cddis.2014.395 – volume: 70 start-page: 1032 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0170 article-title: Overexpressing PRMT1 inhibits proliferation and invasion in pancreatic cancer by inverse correlation of ZEB1 publication-title: IUBMB Life doi: 10.1002/iub.1917 – volume: 7 start-page: 2020 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0335 article-title: USP51 promotes deubiquitination and stabilization of ZEB1 publication-title: Am. J. Cancer Res. – volume: 233 start-page: 7113 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0075 article-title: Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells publication-title: J. Cell. Physiol. doi: 10.1002/jcp.26634 – volume: 36 start-page: 2742 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0465 article-title: Suppression of MicroRNA 200 family expression by oncogenic KRAS activation promotes cell survival and epithelial-mesenchymal transition in KRAS-driven cancer publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00079-16 – volume: 8 start-page: 1453 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0210 article-title: ZEB1 mediates drug resistance and EMT in p300-deficient CRC publication-title: J. Cancer doi: 10.7150/jca.18762 – volume: 5 start-page: 13024 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0365 article-title: Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro publication-title: Sci. Rep. doi: 10.1038/srep13024 – volume: 8 start-page: e2732 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0230 article-title: ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer publication-title: Cell Death Dis. doi: 10.1038/cddis.2017.154 – volume: 138 start-page: 81 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0165 article-title: Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-013-2442-0 – volume: 25 start-page: 119 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0040 article-title: A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial- mesenchymal transition publication-title: Respir. Med. Case Rep. – volume: 213 start-page: 374 year: 2007 ident: 10.1016/j.biopha.2018.11.112_bib0195 article-title: Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression publication-title: J. Cell. Physiol. doi: 10.1002/jcp.21223 – volume: 4 start-page: 2512 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0450 article-title: Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer publication-title: Oncotarget doi: 10.18632/oncotarget.1463 – volume: 289 start-page: 4116 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0375 article-title: The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.533505 – volume: 25 start-page: 282 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0455 article-title: ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.02.025 – volume: 4 start-page: 2650 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0370 article-title: Rb1 family mutation is sufficient for sarcoma initiation publication-title: Nat. Commun. doi: 10.1038/ncomms3650 – volume: 6 start-page: 19874 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0090 article-title: The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1 publication-title: Sci. Rep. doi: 10.1038/srep19874 – volume: 208 start-page: 875 year: 2011 ident: 10.1016/j.biopha.2018.11.112_bib0295 article-title: p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2 publication-title: J. Exp. Med. doi: 10.1084/jem.20110235 – volume: 129 start-page: 497 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0575 article-title: The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia publication-title: Blood doi: 10.1182/blood-2016-05-714493 – volume: 5 start-page: 748 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0405 article-title: Wnt signaling through Snail1 and ZEB1 regulates bone metastasis in lung cancer publication-title: Am. J. Cancer Res. – volume: 7 start-page: 49948 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0525 article-title: Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer publication-title: Oncotarget doi: 10.18632/oncotarget.10521 – volume: 5 start-page: 334 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0225 article-title: Global decrease of histone H3K27 acetylation in ZEB1-Induced epithelial to mesenchymal transition in lung Cancer cells publication-title: Cancers (Basel) doi: 10.3390/cancers5020334 – volume: 36 start-page: 4037 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0275 article-title: MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small cell lung cancer publication-title: Oncogene doi: 10.1038/onc.2017.47 – volume: 126 start-page: 393 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0010 article-title: E-cadherin-integrin crosstalk in cancer invasion and metastasis publication-title: J. Cell. Sci. doi: 10.1242/jcs.100115 – volume: 391 start-page: 59 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0310 article-title: ERK2-ZEB1-miR-101-1 axis contributes to epithelial-mesenchymal transition and cell migration in cancer publication-title: Cancer Lett. doi: 10.1016/j.canlet.2017.01.016 – volume: 13 start-page: 1681 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0240 article-title: SET8 induces epithelial-mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1 publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2015.4733 – volume: 16 start-page: 864 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0120 article-title: ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1 publication-title: Nat. Cell Biol. doi: 10.1038/ncb3013 – volume: 1864 start-page: 2511 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0570 article-title: Epigenetic dysregulation of ZEB1 is involved in LMO2-promoted T-cell acute lymphoblastic leukaemia leukaemogenesis publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2018.05.013 – volume: 14 start-page: 194 year: 1992 ident: 10.1016/j.biopha.2018.11.112_bib0050 article-title: The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2 publication-title: Genomics doi: 10.1016/S0888-7543(05)80307-6 – volume: 31 start-page: 250 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0060 article-title: Downregulation of E-cadherin expression in breast cancer by promoter hypermethylation and its relation with progression and prognosis of tumor publication-title: Med. Oncol. doi: 10.1007/s12032-014-0250-y – volume: 182 start-page: 80 year: 2018 ident: 10.1016/j.biopha.2018.11.112_bib0025 article-title: EMT: mechanisms and therapeutic implications publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2017.08.009 – volume: 96 start-page: 1268 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0545 article-title: Inhibition of NF-kappa B pathway leads to deregulation of epithelial-mesenchymal transition and neural invasion in pancreatic cancer publication-title: Lab. Invest. doi: 10.1038/labinvest.2016.109 – volume: 62 start-page: 1315 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0340 article-title: MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis publication-title: Gut doi: 10.1136/gutjnl-2011-301846 – volume: 124 start-page: 2696 year: 2014 ident: 10.1016/j.biopha.2018.11.112_bib0285 article-title: ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism publication-title: J. Clin. Invest. doi: 10.1172/JCI72171 – volume: 29 start-page: 1579 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0400 article-title: Downregulated microRNA-200a promotes EMT and tumor growth through the Wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma publication-title: Oncol. Rep. doi: 10.3892/or.2013.2267 – volume: 4 start-page: 336 year: 2009 ident: 10.1016/j.biopha.2018.11.112_bib0385 article-title: Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.02.015 – volume: 13 start-page: 788 year: 2013 ident: 10.1016/j.biopha.2018.11.112_bib0475 article-title: The roles of TGFβ in the tumour microenvironment publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3603 – volume: 17 start-page: 719 year: 2017 ident: 10.1016/j.biopha.2018.11.112_bib0585 article-title: Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer publication-title: BMC Cancer doi: 10.1186/s12885-017-3701-y – volume: 35 start-page: 53 year: 2016 ident: 10.1016/j.biopha.2018.11.112_bib0100 article-title: Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis publication-title: J. Exp. Clin. Cancer Res. doi: 10.1186/s13046-016-0329-8 – volume: 137 start-page: 2566 year: 2015 ident: 10.1016/j.biopha.2018.11.112_bib0355 article-title: A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells publication-title: Int. J. Cancer doi: 10.1002/ijc.29642 |
| SSID | ssj0005638 |
| Score | 2.5407104 |
| SecondaryResourceType | review_article |
| Snippet | Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 400 |
| SubjectTerms | E-cadherin EMT Epigenetic HDAC MicroRNA ZEB1 |
| Title | The roles of ZEB1 in tumorigenic progression and epigenetic modifications |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0753332218362048 https://dx.doi.org/10.1016/j.biopha.2018.11.112 https://www.ncbi.nlm.nih.gov/pubmed/30530042 https://www.proquest.com/docview/2155154459 |
| Volume | 110 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEB5EQbyI1ld9sYJ4MrabxyZ7VLFUpSKoIF5CNruBiCbFtgcv_nZnsknVQ1GEXJLdIcnOZB7ZmW8ADjFoIKthHNqkwwBFCifhQjoJflwqDFOjIqp3HtyI_oN_9Rg8zsF5UwtDaZW17rc6vdLW9ZVOvZqdYZ537tDYeR7KIwolgapTwa_vhyTlJx_f0jxE1c2aJjs0uymfq3K8VF4SKBMawQh1B5XTzDJPs9zPygz1VmC59h_ZqX3EVZgzRQsWB_UOeQuObi0W9fsxu_8qrRodsyN2-4VS_b4GlzjMKLdwxMqMPV2ccZYXbDx5pVZZpshTVqVuWdgOlhSamSENUNEjey01pRjZv33r8NC7uD_vO3VfBScN3HDsBFpLDHyVFJnpZprzVEgdUtthbnAdE091pas8HUQiFMizMOA6Qq4JV6lEaOltwHxRFmYLWMZF4gsRoVsofd7tKpFFbqp5hIYx40naBq9ZzjitQcep98VL3GSXPceWCTExAeMRPNw2OFOqoQXd-GV-0HAqbgpKUQXGaBV-oQundD-E7g-UB41AxPg90iZLUphyMopd8kEJ4Ui2YdNKyvQdULcSwJm7_e_77sASnkmbNr4L8-O3idlDr2is9iux34eF08vr_s0nWNYJbw |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS-NAEB-0gt7LcX5e705dQXwytJs0m-yjJ0qrtghWEF-WbHYDOa5JubYP_vc3k01afBBFyFN2hyQ7s_ORnfkNwCkGDWQ1rEeHdBigSOElXEgvwc2loyi1OqZ65-FI9B97N0_h0xpcNrUwlFZZ636n0yttXd_p1KvZmeZ55wGNXRCgPKJQEqh6vA4bhE4VtmDjYnDbH60yPUTV0Jrme0TQVNBVaV46LwmXCe1gjOqDKmreslBveaCVJbr-Bl9rF5JduLfchjVb7MDmsD4k34GzewdH_XLOxqvqqtk5O2P3K6Dql10Y4DCj9MIZKzP2fPWbs7xg88WEumXZIk9Zlb3lkDtYUhhmpzRAdY9sUhrKMnI__Pbg8fpqfNn36tYKXhr60dwLjZEY-2opMtvNDOepkCaizsPc4lImge5KXwcmjEUkkG1RyE2MjBO-1okwMtiHVlEW9juwjIukJ0SMnqHs8W5Xiyz2U8NjtI0ZT9I2BM1yqrTGHaf2F39Vk2D2RzkmKGIChiR4-W3wllRTh7vxzvyw4ZRqakpRCyo0DO_QRUu6V3L3AcqTRiAUbkk6Z0kKWy5myic3lECOZBsOnKQsvwHVK2Gc-T8-_dxj2OqPh3fqbjC6_QlfcES6LPJf0Jr_W9hDdJLm-qjeBP8Ba5sMIA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+roles+of+ZEB1+in+tumorigenic+progression+and+epigenetic+modifications&rft.jtitle=Biomedicine+%26+pharmacotherapy&rft.au=Zhang%2C+Yu&rft.au=Xu%2C+Lei&rft.au=Li%2C+Anqi&rft.au=Han%2C+Xiuzhen&rft.date=2019-02-01&rft.eissn=1950-6007&rft.volume=110&rft.spage=400&rft_id=info:doi/10.1016%2Fj.biopha.2018.11.112&rft_id=info%3Apmid%2F30530042&rft.externalDocID=30530042 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0753-3322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0753-3322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0753-3322&client=summon |