Mechanical overload-induced release of extracellular mitochondrial particles from tendon cells leads to inflammation in tendinopathy

• Published in: Experimental & molecular medicine Vol. 56; no. 3; pp. 583 - 599
• Main Authors: Chen, Ziming, Li, Mengyuan, Chen, Peilin, Tai, Andrew, Li, Jiayue, Bassonga, Euphemie Landao, Gao, Junjie, Liu, Delin, Wood, David, Kennedy, Brendan F., Zheng, Qiujian, Zheng, Ming H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2024; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 13; 13/107; 14; 14/19; 14/34; 14/63; 38; 38/77; 38/91; 631/80/642/333/1465; 692/308/1426; 692/420/256/2515; 692/699/578; 82; 82/29; 96/21; Acetylcysteine; Artificial intelligence; Biomedical and Life Sciences; Biomedicine; Bioreactors; Chemotaxis; Confocal microscopy; Inflammation; Macrophages; Mechanical loading; Medical Biochemistry; Microenvironments; Mitochondria; Molecular Medicine; Muscles; Musculoskeletal diseases; Stem Cells; Tendons; 생화학

Tendinopathy is one of the most common musculoskeletal diseases, and mechanical overload is considered its primary cause. However, the underlying mechanism through which mechanical overload induces tendinopathy has not been determined. In this study, we identified for the first time that tendon cell...