Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains

• Published in: Biochimica et biophysica acta Vol. 1780; no. 3; pp. 421 - 433
• Main Authors: Regina Todeschini, Adriane, Hakomori, Sen-itiroh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2008
• Subjects: Animals; Caveolae - metabolism; Cell Adhesion; Cell Movement; Cell Proliferation; Ganglioside; Gangliosides - chemistry; Gangliosides - metabolism; Glycosphingolipids microdomain; Glycosylation; Glycosynapse; Humans; Integrin; Membrane Microdomains - metabolism; Tetraspanin; GPI; GSL; Ecad; LN; nOe; TSPs; HGF; CCI; Glycosphingolipids microdomain; Glycosylation; FGFR; EGFR; ECM; GEM; TD; Neu3; GFR; NMR; Integrin; Ganglioside; Le; Glycosynapse; Tetraspanin

At cell surface microdomains, glycosyl epitopes, carried either by glycosphingolipids, N- or O-linked oligosaccharides, are recognized by carbohydrate-binding proteins or complementary carbohydrates. In both cases, the carbohydrate epitopes may be clustered with specific signal transducers, tetraspa...