Epigenetic Inheritance and the Missing Heritability Problem

• Published in: Genetics (Austin) Vol. 182; no. 3; pp. 845 - 850
• Main Author: Slatkin, Montgomery
• Format: Journal Article
• Language: English
• Published: United States Genetics Soc America 01.07.2009; Genetics Society of America
• Subjects: Algorithms; Animals; Epigenesis, Genetic - genetics; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study - methods; Health risks; Humans; Investigations; Linkage Disequilibrium; Models, Genetic; Mutation; Polymorphism, Single Nucleotide; Time Factors

Epigenetic phenomena, and in particular heritable epigenetic changes, or transgenerational effects, are the subject of much discussion in the current literature. This article presents a model of transgenerational epigenetic inheritance and explores the effect of epigenetic inheritance on the risk an...