Regulation of Bone Mass, Osteoclast Function, and Ovariectomy-Induced Bone Loss by the Type 2 Cannabinoid Receptor

• Published in: Endocrinology (Philadelphia) Vol. 149; no. 11; pp. 5619 - 5626
• Main Authors: Idris, Aymen I, Sophocleous, Antonia, Landao-Bassonga, Euphemie, van't Hof, Robert J, Ralston, Stuart H
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.11.2008; Oxford University Press
• Subjects: Animals; Biological and medical sciences; Bone and Bones - anatomy & histology; Bone Density - genetics; Bone diseases; Bone growth; Bone loss; Bone Marrow Cells - drug effects; Bone mass; Bone resorption; Bone Resorption - etiology; Bone Resorption - genetics; Bone turnover; Cannabinoid CB2 receptors; Cannabinoids - pharmacology; Cells, Cultured; Coculture Techniques; Diseases of the osteoarticular system; Drug Evaluation, Preclinical; Drug Inverse Agonism; Endocannabinoid system; Female; Fundamental and applied biological sciences. Psychology; Indoles - pharmacology; Inverse agonists; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Oophorectomy; Organ Size - genetics; Osteoclasts; Osteoclasts - drug effects; Osteoclasts - metabolism; Osteoclasts - physiology; Osteoporosis. Osteomalacia. Paget disease; Ovariectomy; Ovariectomy - adverse effects; Piperidines - pharmacology; Pyrazoles - pharmacology; Receptor, Cannabinoid, CB2 - agonists; Receptor, Cannabinoid, CB2 - antagonists & inhibitors; Receptor, Cannabinoid, CB2 - genetics; Receptor, Cannabinoid, CB2 - physiology; Receptors; Vertebrates: endocrinology; Osteoarticular system; Bone mass; Ovariectomy; Cannabinoid receptor; Diseases of the osteoarticular system; Osteoclast; Bone; Osteopenia

The endocannabinoid system has recently been shown to play a role in the regulation of bone metabolism. The type 2 cannabinoid receptor (CB2) has been reported to regulate bone mass, but conflicting results have been reported with regard to its effects on bone resorption and osteoclast function. Her...