Salivary cortisol awakening levels are reduced in human subjects with intermittent explosive disorder compared with controls

• Published in: Psychoneuroendocrinology Vol. 151; p. 106070
• Main Authors: Meruelo, Alejandro D., Timmins, Matthew A., Irwin, Michael R., Coccaro, Emil F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2023
• Subjects: Adult; Aggression; Aggression - physiology; C-reactive protein; Cortisol; Disruptive, Impulse Control, and Conduct Disorders; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; IED; Impulsivity; Inflammation; Interleukin-6; Pituitary-Adrenal System; Research Subjects; IED; Impulsivity; Cortisol; C-reactive protein; Aggression

The role of the hypothalamic-pituitary-adrenal (HPA) axis in human aggressive behavior is poorly characterized, though some studies report that, unlike depression, circulating or salivary levels of cortisol are low compared with controls. In this study, we collected three salivary cortisol levels (t...