Red cell membrane: past, present, and future

• Published in: Blood Vol. 112; no. 10; pp. 3939 - 3948
• Main Authors: Mohandas, Narla, Gallagher, Patrick G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2008; American Society of Hematology
• Series: ASH 50th Anniversary Reviews
• Subjects: ASH 50th Anniversary Reviews; Biological Transport; Erythrocyte Membrane - metabolism; Erythrocyte Membrane - pathology; Erythrocytes, Abnormal - metabolism; Erythrocytes, Abnormal - pathology; Humans; Isoantigens - metabolism; Malaria - epidemiology; Malaria - metabolism; Membrane Proteins - metabolism; Selection, Genetic; Structure-Activity Relationship

As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma me...