Red cell membrane: past, present, and future

As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma me...

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Published in	Blood Vol. 112; no. 10; pp. 3939 - 3948
Main Authors	Mohandas, Narla, Gallagher, Patrick G.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 15.11.2008 American Society of Hematology
Series	ASH 50th Anniversary Reviews
Subjects	ASH 50th Anniversary Reviews Biological Transport Erythrocyte Membrane - metabolism Erythrocyte Membrane - pathology Erythrocytes, Abnormal - metabolism Erythrocytes, Abnormal - pathology Humans Isoantigens - metabolism Malaria - epidemiology Malaria - metabolism Membrane Proteins - metabolism Selection, Genetic Structure-Activity Relationship
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Abstract	As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types.
AbstractList	As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types. As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types.As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types.
Author	Mohandas, Narla Gallagher, Patrick G.
Author_xml	– sequence: 1 givenname: Narla surname: Mohandas fullname: Mohandas, Narla email: MNarla@NYBloodcenter.org organization: Red Cell Physiology Laboratory, New York Blood Center, New York, NY – sequence: 2 givenname: Patrick G. surname: Gallagher fullname: Gallagher, Patrick G. organization: Department of Pediatrics, Yale University School of Medicine, New Haven, CT
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18988878$$D View this record in MEDLINE/PubMed
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Snippet	As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell...
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SubjectTerms	ASH 50th Anniversary Reviews Biological Transport Erythrocyte Membrane - metabolism Erythrocyte Membrane - pathology Erythrocytes, Abnormal - metabolism Erythrocytes, Abnormal - pathology Humans Isoantigens - metabolism Malaria - epidemiology Malaria - metabolism Membrane Proteins - metabolism Selection, Genetic Structure-Activity Relationship
Title	Red cell membrane: past, present, and future
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