Molecular biology of bcr-abl1–positive chronic myeloid leukemia

• Published in: Blood Vol. 113; no. 8; pp. 1619 - 1630
• Main Authors: Quintás-Cardama, Alfonso, Cortes, Jorge
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.02.2009; American Society of Hematology
• Series: Review Article
• Subjects: Animals; Fusion Proteins, bcr-abl - genetics; Fusion Proteins, bcr-abl - metabolism; Gene Expression Regulation, Leukemic - physiology; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - physiopathology; Molecular Biology; Review; Signal Transduction - physiology

Chronic myeloid leukemia (CML) has been regarded as the paradigmatic example of a malignancy defined by a unique molecular event, the BCR-ABL1 oncogene. Decades of research zeroing in on the role of BCR-ABL1 kinase in the pathogenesis of CML have culminated in the development of highly efficacious t...