Evaluation of safe utilization of l-threonine for supplementation in healthy adults: a randomized double blind controlled trial

• Published in: Amino acids Vol. 57; no. 1; p. 30
• Main Authors: Matsumoto, Hideki, Miura, Naoki, Naito, Masaki, Elango, Rajavel
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 27.05.2025; Springer Nature B.V; Springer
• Subjects: Adult; Adults; Adverse events; Amino acid; Amino acids; Analytical Chemistry; Anthropometry; aspartate transaminase; Biochemical Engineering; Biochemistry; Biomedical and Life Sciences; blood; Blood pressure; Blood Pressure - drug effects; butylate; Clinical trials; Creatine; Creatine kinase; Creatine Kinase - blood; Cross-Over Studies; Dietary intake; Dietary supplements; Dietary Supplements - adverse effects; Double-Blind Method; Evaluation; Food intake; Healthy Volunteers; Heart rate; Human study; Humans; Kinases; Life Sciences; Male; males; Metabolites; Middle Aged; Neurobiology; no observed adverse effect level; NOAEL; Original; Original Article; Parameters; Physical examinations; placebos; Proteomics; Randomized controlled clinical trial; Threonine; Threonine - administration & dosage; Threonine - adverse effects; Threonine - blood; Randomized controlled clinical trial; Amino acid; Threonine; Human study; NOAEL

l -threonine is used in dietary supplements and nutritional products ingested by healthy consumers. The objective of this study was to determine in a randomized double blind controlled clinical trial the safety and tolerability of l -threonine used as graded doses in supplements for 4 weeks. Healthy...