Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice

• Published in: Life sciences (1973) Vol. 159; pp. 71 - 75
• Main Authors: Houde, Martin, Desbiens, Louisane, Schwertani, Adel, Pejler, Gunnar, Iglarz, Marc, D'Orléans-Juste, Pedro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.08.2016
• Subjects: actin; Animals; antagonists; Aorta - pathology; Apolipoprotein E; arteries; Atherosclerosis; Atherosclerosis - pathology; Chymase; Endothelin; Endothelin Receptor Antagonists - pharmacology; endothelin receptors; high fat diet; Immunologi inom det medicinska området; Immunology in the medical area; Macitentan; mast cells; Mice; Mice, Knockout; muscles; proteinases; Pyrimidines - pharmacology; Serine Endopeptidases - genetics; Serine Endopeptidases - metabolism; staining; Sudan dyes; Sulfonamides - pharmacology; Macitentan; Endothelin; Apolipoprotein E; Atherosclerosis; Chymase

To determine the impact of mixed endothelin receptor antagonist and mouse mast cell protease-4 (mMCP-4) in the development of atherosclerosis in the mouse model. Apolipoprotein E (ApoE) KO mice were crossed with mMCP-4 KO mice to generate ApoE/mMCP-4 double KO mice. Atherosclerosis was induced with...