Effect of catalpol on behavior and neurodevelopment in an ADHD rat model

• Published in: Biomedicine & pharmacotherapy Vol. 118; p. 109033
• Main Authors: Yuan, Haixia, Ni, Xinqiang, Zheng, Min, Han, Xinmin, Song, Yuchen, Yu, Minfeng
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2019
• Subjects: ADHD; Animals; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - physiopathology; Behavior, Animal - drug effects; Catalpol; Central Nervous System Stimulants - therapeutic use; Corpus Striatum - drug effects; Corpus Striatum - pathology; Disease Models, Animal; Iridoid Glucosides - therapeutic use; Male; Maze Learning - drug effects; Memory - drug effects; Methylphenidate - therapeutic use; Morris water maze; Motor Activity - drug effects; Neurodevelopment; Neurons - drug effects; Neurons - pathology; Neuroprotective Agents - therapeutic use; Open field test; Prefrontal Cortex - drug effects; Prefrontal Cortex - pathology; Rats, Inbred SHR; Rats, Inbred WKY; ADHD; MWM; Morris water maze; MPH; WKY; FGF; BDNF; H&E; Catalpol; Open field test; PFC; FGFR; Cdk5; Neurodevelopment; MBP; SHR; OFT

•Catalpol attenuated hyperactivity and impulsiveness in SHR.•Catalpol improved spatial learning and memory of SHR.•Catalpol alleviated histomorphological changes in PFC and striatum of SHR.•Catalpol displayed neuroprotective effects and contributed to myelination.•Catalpol affected regulatory protei...