Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization
[Display omitted] Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the restoration of cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage is a complex...
Saved in:
| Published in | Biomedicine & pharmacotherapy Vol. 125; p. 109945 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
France
Elsevier Masson SAS
01.05.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the restoration of cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage is a complex pathological process with an unclear physiological mechanism, more attention is currently focused on the neuroinflammatory response of an ischemia/reperfusion origin, and anti-inflammatory appears to be a potential therapeutic strategy following ischemic stroke. QiShenYiQi (QSYQ), a component-based Chinese medicine with Qi-tonifying and blood-activating property, has pharmacological actions of anti-inflammatory, antioxidant, mitochondrial protectant, anti-apoptosis, and antiplatelet aggregation. We have previously reported that the cardioprotective effect of QSYQ against ischemia/reperfusion injury is via improvement of mitochondrial functional integrity. In this research work, we aimed to investigate the possible mechanism involved in the neuroprotection of QSYQ in mice model of cerebral ischemia/reperfusion injury based on the inflammatory pathway. The cerebral protection was evaluated in the stroke mice after 24 h reperfusion by assessing the neurological deficit, cerebral infarction, brain edema, BBB functionality, and via histopathological assessment. TCM-based network pharmacology method was performed to establish and analyze compound-target-disease & function-pathway network so as to find the possible mechanism linking to the role of QSYQ in CI/RI. In addition, RT-qPCR was used to verify the accuracy of predicted signaling gene expression. As a result, improvement of neurological outcome, reduction of infarct volume and brain edema, a decrease in BBB disruption, and amelioration of histopathological alteration were observed in mice pretreated with QSYQ after experimental stroke surgery. Network pharmacology analysis revealed neuroinflammatory response was associated with the action of QSYQ in CI/RI. RT-qPCR data showed that the mice pretreated with QSYQ could significantly decrease IFNG-γ, IL-6, TNF-α, NF-κB p65, and TLR-4 mRNA levels and increase TGF-β1 mRNA level in the brain compared to the untreated mice after CI/RI (p < 0.05). In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. |
|---|---|
| AbstractList | Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the restoration of cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage is a complex pathological process with an unclear physiological mechanism, more attention is currently focused on the neuroinflammatory response of an ischemia/reperfusion origin, and anti-inflammatory appears to be a potential therapeutic strategy following ischemic stroke. QiShenYiQi (QSYQ), a component-based Chinese medicine with Qi-tonifying and blood-activating property, has pharmacological actions of anti-inflammatory, antioxidant, mitochondrial protectant, anti-apoptosis, and antiplatelet aggregation. We have previously reported that the cardioprotective effect of QSYQ against ischemia/reperfusion injury is via improvement of mitochondrial functional integrity. In this research work, we aimed to investigate the possible mechanism involved in the neuroprotection of QSYQ in mice model of cerebral ischemia/reperfusion injury based on the inflammatory pathway. The cerebral protection was evaluated in the stroke mice after 24 h reperfusion by assessing the neurological deficit, cerebral infarction, brain edema, BBB functionality, and via histopathological assessment. TCM-based network pharmacology method was performed to establish and analyze compound-target-disease & function-pathway network so as to find the possible mechanism linking to the role of QSYQ in CI/RI. In addition, RT-qPCR was used to verify the accuracy of predicted signaling gene expression. As a result, improvement of neurological outcome, reduction of infarct volume and brain edema, a decrease in BBB disruption, and amelioration of histopathological alteration were observed in mice pretreated with QSYQ after experimental stroke surgery. Network pharmacology analysis revealed neuroinflammatory response was associated with the action of QSYQ in CI/RI. RT-qPCR data showed that the mice pretreated with QSYQ could significantly decrease IFNG-γ, IL-6, TNF-α, NF-κB p65, and TLR-4 mRNA levels and increase TGF-β1 mRNA level in the brain compared to the untreated mice after CI/RI (p < 0.05). In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject.Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the restoration of cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage is a complex pathological process with an unclear physiological mechanism, more attention is currently focused on the neuroinflammatory response of an ischemia/reperfusion origin, and anti-inflammatory appears to be a potential therapeutic strategy following ischemic stroke. QiShenYiQi (QSYQ), a component-based Chinese medicine with Qi-tonifying and blood-activating property, has pharmacological actions of anti-inflammatory, antioxidant, mitochondrial protectant, anti-apoptosis, and antiplatelet aggregation. We have previously reported that the cardioprotective effect of QSYQ against ischemia/reperfusion injury is via improvement of mitochondrial functional integrity. In this research work, we aimed to investigate the possible mechanism involved in the neuroprotection of QSYQ in mice model of cerebral ischemia/reperfusion injury based on the inflammatory pathway. The cerebral protection was evaluated in the stroke mice after 24 h reperfusion by assessing the neurological deficit, cerebral infarction, brain edema, BBB functionality, and via histopathological assessment. TCM-based network pharmacology method was performed to establish and analyze compound-target-disease & function-pathway network so as to find the possible mechanism linking to the role of QSYQ in CI/RI. In addition, RT-qPCR was used to verify the accuracy of predicted signaling gene expression. As a result, improvement of neurological outcome, reduction of infarct volume and brain edema, a decrease in BBB disruption, and amelioration of histopathological alteration were observed in mice pretreated with QSYQ after experimental stroke surgery. Network pharmacology analysis revealed neuroinflammatory response was associated with the action of QSYQ in CI/RI. RT-qPCR data showed that the mice pretreated with QSYQ could significantly decrease IFNG-γ, IL-6, TNF-α, NF-κB p65, and TLR-4 mRNA levels and increase TGF-β1 mRNA level in the brain compared to the untreated mice after CI/RI (p < 0.05). In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. [Display omitted] Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the restoration of cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage is a complex pathological process with an unclear physiological mechanism, more attention is currently focused on the neuroinflammatory response of an ischemia/reperfusion origin, and anti-inflammatory appears to be a potential therapeutic strategy following ischemic stroke. QiShenYiQi (QSYQ), a component-based Chinese medicine with Qi-tonifying and blood-activating property, has pharmacological actions of anti-inflammatory, antioxidant, mitochondrial protectant, anti-apoptosis, and antiplatelet aggregation. We have previously reported that the cardioprotective effect of QSYQ against ischemia/reperfusion injury is via improvement of mitochondrial functional integrity. In this research work, we aimed to investigate the possible mechanism involved in the neuroprotection of QSYQ in mice model of cerebral ischemia/reperfusion injury based on the inflammatory pathway. The cerebral protection was evaluated in the stroke mice after 24 h reperfusion by assessing the neurological deficit, cerebral infarction, brain edema, BBB functionality, and via histopathological assessment. TCM-based network pharmacology method was performed to establish and analyze compound-target-disease & function-pathway network so as to find the possible mechanism linking to the role of QSYQ in CI/RI. In addition, RT-qPCR was used to verify the accuracy of predicted signaling gene expression. As a result, improvement of neurological outcome, reduction of infarct volume and brain edema, a decrease in BBB disruption, and amelioration of histopathological alteration were observed in mice pretreated with QSYQ after experimental stroke surgery. Network pharmacology analysis revealed neuroinflammatory response was associated with the action of QSYQ in CI/RI. RT-qPCR data showed that the mice pretreated with QSYQ could significantly decrease IFNG-γ, IL-6, TNF-α, NF-κB p65, and TLR-4 mRNA levels and increase TGF-β1 mRNA level in the brain compared to the untreated mice after CI/RI (p < 0.05). In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the restoration of cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage is a complex pathological process with an unclear physiological mechanism, more attention is currently focused on the neuroinflammatory response of an ischemia/reperfusion origin, and anti-inflammatory appears to be a potential therapeutic strategy following ischemic stroke. QiShenYiQi (QSYQ), a component-based Chinese medicine with Qi-tonifying and blood-activating property, has pharmacological actions of anti-inflammatory, antioxidant, mitochondrial protectant, anti-apoptosis, and antiplatelet aggregation. We have previously reported that the cardioprotective effect of QSYQ against ischemia/reperfusion injury is via improvement of mitochondrial functional integrity. In this research work, we aimed to investigate the possible mechanism involved in the neuroprotection of QSYQ in mice model of cerebral ischemia/reperfusion injury based on the inflammatory pathway. The cerebral protection was evaluated in the stroke mice after 24 h reperfusion by assessing the neurological deficit, cerebral infarction, brain edema, BBB functionality, and via histopathological assessment. TCM-based network pharmacology method was performed to establish and analyze compound-target-disease & function-pathway network so as to find the possible mechanism linking to the role of QSYQ in CI/RI. In addition, RT-qPCR was used to verify the accuracy of predicted signaling gene expression. As a result, improvement of neurological outcome, reduction of infarct volume and brain edema, a decrease in BBB disruption, and amelioration of histopathological alteration were observed in mice pretreated with QSYQ after experimental stroke surgery. Network pharmacology analysis revealed neuroinflammatory response was associated with the action of QSYQ in CI/RI. RT-qPCR data showed that the mice pretreated with QSYQ could significantly decrease IFNG-γ, IL-6, TNF-α, NF-κB p65, and TLR-4 mRNA levels and increase TGF-β1 mRNA level in the brain compared to the untreated mice after CI/RI (p < 0.05). In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. |
| ArticleNumber | 109945 |
| Author | Zhu, Lin Yang, Xinyue Zhang, Yiqian Wang, Xiaoying Wang, Yule Feng, Yuxin Liu, Xinyan Xiao, Guangxu He, Shuang Orgah, John Zhang, Boli Zhu, Yan |
| Author_xml | – sequence: 1 givenname: Yule surname: Wang fullname: Wang, Yule organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 2 givenname: Guangxu surname: Xiao fullname: Xiao, Guangxu organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 3 givenname: Shuang surname: He fullname: He, Shuang organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 4 givenname: Xinyan surname: Liu fullname: Liu, Xinyan organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 5 givenname: Lin surname: Zhu fullname: Zhu, Lin organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 6 givenname: Xinyue surname: Yang fullname: Yang, Xinyue organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 7 givenname: Yiqian surname: Zhang fullname: Zhang, Yiqian organization: State Key Laboratory of Core Technology in Innovative Chinese Medicine, Tianjin Tasly Holding Group Co., Ltd., Tianjin, China – sequence: 8 givenname: John surname: Orgah fullname: Orgah, John organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 9 givenname: Yuxin surname: Feng fullname: Feng, Yuxin organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 10 givenname: Xiaoying surname: Wang fullname: Wang, Xiaoying organization: Neuroscience Program, Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States – sequence: 11 givenname: Boli surname: Zhang fullname: Zhang, Boli organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China – sequence: 12 givenname: Yan orcidid: 0000-0002-3197-7936 surname: Zhu fullname: Zhu, Yan email: yanzhu.harvard@icloud.com organization: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32028240$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1u1DAURi1URKeFN0AoSzaZXjtxfhBCQhUUpEpQAQtWluO5Ye40sae2M2j69DhMu-lmVpatcz77-jtjJ9ZZZOw1hyUHXl1slh257VovBYj5qG1L-YwteCshrwDqE7aAWhZ5UQhxys5C2ACArIrmBTstktOIEhZs9927iCaSs5n-o8mGmGkzRcwMeuy8HjIKZo0j6QuPW_T9FGaW7Gby-6zbZzf0Y432N91QtiOdWZy8I9sPehx1dImxGP86f5uNrqOB7vV810v2vNdDwFcP6zn79fnTz8sv-fW3q6-XH69zI0Udcw69bngFvSxbzTWgqdK7uwb62shaSJP2RiK0fVs2jSka0SJgrw3nNSCuinP29pC79e5uwhDVmMbBYdAW3RSUKKSoSoCqSeibB3TqRlypradR-716_KsEvDsAxrsQPPbKUPw_TfSaBsVBzcWojToUo-Zi1KGYJJdP5Mf8I9qHg4bpk3aEXgVDaA2uyKfW1MrRsYD3TwLMQJaMHm5xf1z_B9MwwBU |
| CitedBy_id | crossref_primary_10_1016_j_neuroscience_2024_09_013 crossref_primary_10_1016_j_jep_2023_117610 crossref_primary_10_1016_j_biopha_2021_111828 crossref_primary_10_1016_j_intimp_2025_114229 crossref_primary_10_2174_1874467214666210811153610 crossref_primary_10_1016_j_phrs_2021_105460 crossref_primary_10_1016_j_jep_2021_114224 crossref_primary_10_1097_WNR_0000000000001940 crossref_primary_10_1093_bbb_zbab086 crossref_primary_10_3389_fphar_2021_759027 crossref_primary_10_1089_acm_2020_0455 crossref_primary_10_1177_09731296231215158 crossref_primary_10_1016_j_chmed_2020_12_003 crossref_primary_10_1016_j_phymed_2021_153637 crossref_primary_10_1016_j_phymed_2022_154609 crossref_primary_10_2147_DDDT_S479881 crossref_primary_10_3389_fphar_2022_934256 crossref_primary_10_3389_fnins_2022_901360 crossref_primary_10_1016_j_jep_2022_115301 crossref_primary_10_1007_s10565_024_09961_7 crossref_primary_10_1016_j_phymed_2022_154072 crossref_primary_10_3390_cimb46070437 crossref_primary_10_1007_s11356_023_30708_0 crossref_primary_10_1016_j_phymed_2022_154034 crossref_primary_10_12688_f1000research_151380_2 crossref_primary_10_12688_f1000research_151380_1 crossref_primary_10_1097_MD_0000000000039820 crossref_primary_10_1007_s12013_024_01597_y crossref_primary_10_1016_j_expneurol_2022_114266 crossref_primary_10_1080_13880209_2022_2103718 crossref_primary_10_1007_s11011_025_01570_5 crossref_primary_10_3390_antiox10071088 crossref_primary_10_3390_pharmaceutics13091357 crossref_primary_10_1002_brb3_3195 crossref_primary_10_1016_j_biopha_2023_114240 crossref_primary_10_1080_00207454_2023_2273767 crossref_primary_10_3389_fimmu_2022_1007341 crossref_primary_10_1186_s41016_021_00264_y crossref_primary_10_1016_j_biopha_2022_113744 crossref_primary_10_3390_ijms23179648 crossref_primary_10_4103_wjtcm_wjtcm_21_21 crossref_primary_10_2147_JIR_S448620 crossref_primary_10_2174_0115672026313555240515103132 crossref_primary_10_3390_ijms23010135 crossref_primary_10_3389_fphar_2021_770329 crossref_primary_10_3389_fphar_2022_963179 crossref_primary_10_3389_fphar_2021_688596 crossref_primary_10_1111_cns_14836 crossref_primary_10_1097_MD_0000000000034424 crossref_primary_10_1007_s43440_024_00620_6 crossref_primary_10_1177_02841851241275278 crossref_primary_10_3389_fphar_2021_760503 crossref_primary_10_1016_j_biopha_2020_110723 crossref_primary_10_1016_j_heliyon_2024_e39162 crossref_primary_10_1080_13880209_2022_2070221 crossref_primary_10_1186_s40580_024_00423_8 crossref_primary_10_3389_fcell_2021_649891 crossref_primary_10_1007_s10753_020_01303_z crossref_primary_10_2147_JIR_S473665 crossref_primary_10_1002_tox_23916 crossref_primary_10_1016_j_jep_2022_115953 crossref_primary_10_1016_j_jep_2022_115316 crossref_primary_10_1016_j_jep_2023_116507 crossref_primary_10_1016_j_phymed_2021_153702 crossref_primary_10_1186_s12951_024_02771_3 crossref_primary_10_3390_biomedicines11030689 crossref_primary_10_3389_fphar_2021_588587 crossref_primary_10_1016_j_mtbio_2025_101500 crossref_primary_10_1186_s12951_024_02584_4 |
| Cites_doi | 10.1038/s41598-017-14692-3 10.1016/j.brainresbull.2015.05.002 10.1007/s11356-017-0149-1 10.2147/DDDT.S82146 10.3389/fneur.2017.00467 10.1186/s12938-017-0359-2 10.1016/j.phymed.2010.03.017 10.3389/fphar.2018.00715 10.1016/S0140-6736(12)60738-7 10.1093/database/bax028 10.3389/fphar.2018.00692 10.1007/s004010050596 10.1016/j.jep.2018.02.041 10.1177/0271678X16679671 10.1161/01.STR.32.2.544 10.1016/j.neuroscience.2011.11.005 10.1161/01.STR.26.4.676 10.1016/j.imbio.2012.07.024 10.1038/s41598-017-07659-x 10.3724/SP.J.1009.2013.00110 10.1038/s41596-018-0066-x 10.1093/jnen/63.9.942 10.1016/j.phrs.2019.104386 10.1016/j.pharmthera.2017.03.005 10.1016/S0165-5728(01)00264-8 10.1161/01.STR.20.1.84 10.1038/jcbfm.2009.32 10.1016/j.apsb.2014.11.002 10.1038/nm.2399 10.1186/1758-2946-6-13 10.1002/j.2040-4603.2017.tb00741.x 10.1002/jnr.20180 10.1038/sj.bjp.0706837 10.1186/1472-6882-8-58 10.1016/j.jns.2014.02.002 10.1039/C7MB00003K 10.2174/1567202611666140530145643 10.1002/bmc.3468 10.1007/s00221-015-4352-3 10.1186/s12906-018-2356-9 10.1161/CIRCULATIONAHA.105.593046 10.1161/CIRCULATIONAHA.106.603431 10.4103/njcp.njcp_367_18 10.1152/ajpcell.00095.2018 10.1161/CIR.0000000000000659 10.1111/j.1600-0404.2005.00416.x 10.1093/nar/gku1055 10.1111/jnc.13607 10.3390/ijms13078219 10.1016/B978-0-12-394309-5.00006-7 10.1186/s12974-019-1516-2 10.1093/nar/gky1033 10.1002/bmc.4585 10.1161/01.STR.24.1.117 10.1155/2017/8424326 10.1007/s12035-017-0552-0 10.3390/ijms17071190 10.1038/sj.bjp.0706945 10.1007/s12035-014-8764-z 10.3390/molecules22071135 10.1016/j.neuroscience.2010.08.054 10.1093/nar/gkx1028 10.1111/j.1750-3639.2012.00614.x 10.1155/2017/7062714 10.1093/bioinformatics/btt703 10.1161/STROKEAHA.118.021754 10.1016/j.jstrokecerebrovasdis.2018.09.041 10.1212/CPJ.0000000000000632 10.1016/j.pneurobio.2017.10.001 10.1007/s00234-006-0183-z 10.1371/journal.pone.0148503 10.2174/0929867321666131228205146 10.1038/srep21146 10.1161/01.STR.0000120732.45951.26 10.1146/annurev.iy.12.040194.001041 10.3389/fphar.2019.01133 10.2174/0929867322666150209154036 10.1038/jcbfm.2012.88 10.1097/00004647-200209000-00004 10.3995/jstroke.8.1 10.1002/cpbi.27 10.1161/01.STR.31.7.1715 10.1016/j.molimm.2018.01.011 10.1016/j.jchromb.2018.10.011 10.3390/cells7120270 10.3389/fphys.2019.01174 10.3389/fphar.2019.00204 |
| ContentType | Journal Article |
| Copyright | 2020 The Authors Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
| Copyright_xml | – notice: 2020 The Authors – notice: Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.biopha.2020.109945 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1950-6007 |
| ExternalDocumentID | 32028240 10_1016_j_biopha_2020_109945 S0753332220301359 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABMAC ABMZM ABWVN ABXDB ABZDS ACDAQ ACIEU ACIUM ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGYEJ AHHHB AI. AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALCLG ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OD~ OGGZJ OK1 OO0 OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SDF SDG SDP SEM SES SEW SPT SSH SSP SSZ T5K VH1 WUQ Z5R ~02 ~G- 6I. AAFTH AFCTW AGRNS RIG AAYXX CITATION AACTN AFKWA AJOXV AMFUW CGR CUY CVF ECM EIF GROUPED_DOAJ NCXOZ NPM 7X8 |
| ID | FETCH-LOGICAL-c527t-10fa8160f549a1a0ec6282b80f7c5725cc62c5e09f9488c3829e0efac1170eed3 |
| IEDL.DBID | .~1 |
| ISSN | 0753-3322 1950-6007 |
| IngestDate | Mon Jul 21 11:09:49 EDT 2025 Wed Feb 19 02:29:51 EST 2025 Wed Aug 20 07:44:00 EDT 2025 Thu Apr 24 23:10:15 EDT 2025 Sat Jul 19 17:11:27 EDT 2025 Tue Aug 26 16:34:43 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | NO TTC BBB ASCVD HMGB1 HSPs NF-κB CI/RI Neuroinflammatory response QiShenYiQi Cerebral ischemia/reperfusion injury QSYQ EB MCAO CCA ECA IL-1 ICA H&E MMPs IFNG-γ IL-6 TNF-α ROS TCM-based network pharmacology CVDs TLRs TCM |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c527t-10fa8160f549a1a0ec6282b80f7c5725cc62c5e09f9488c3829e0efac1170eed3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-3197-7936 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0753332220301359 |
| PMID | 32028240 |
| PQID | 2352640068 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2352640068 pubmed_primary_32028240 crossref_citationtrail_10_1016_j_biopha_2020_109945 crossref_primary_10_1016_j_biopha_2020_109945 elsevier_sciencedirect_doi_10_1016_j_biopha_2020_109945 elsevier_clinicalkey_doi_10_1016_j_biopha_2020_109945 |
| PublicationCentury | 2000 |
| PublicationDate | May 2020 2020-05-00 2020-May 20200501 |
| PublicationDateYYYYMMDD | 2020-05-01 |
| PublicationDate_xml | – month: 05 year: 2020 text: May 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | France |
| PublicationPlace_xml | – name: France |
| PublicationTitle | Biomedicine & pharmacotherapy |
| PublicationTitleAlternate | Biomed Pharmacother |
| PublicationYear | 2020 |
| Publisher | Elsevier Masson SAS |
| Publisher_xml | – name: Elsevier Masson SAS |
| References | Xie, Zhou, Sun (bib0115) 2018; 7 Yoshimoto, Houkin, Tada, Abe (bib0410) 1997; 93 He, Ma, Li (bib0185) 2017; 37 Dobolyi, Vincze, Pal (bib0435) 2012; 13 Jiang, Andjelkovic, Zhu (bib0350) 2018; 163-164 Lambertsen, Biber, Finsen (bib0170) 2012; 32 Iadecola, Anrather (bib0440) 2011; 17 Tang, Xue, Bai (bib0140) 2010; 17 Ghatge, Nair, Sharma (bib0250) 2018; 17 Kim, Chen, Cheng (bib0295) 2019; 47 Haddad, Rhinn, Bloquel (bib0430) 2006; 149 Kramer, Green, Pollard (bib0315) 2014; 30 Chen, Zheng, Yan (bib0480) 2019; 33 Zheng, Zhang, Qiao (bib0305) 2015; 2015 Yuan, Ma, Cui (bib0360) 2017; 22 Zhang, Li, Li (bib0335) 2012; 201 Lin, Wang, Yu (bib0030) 2016; 5 Qian, Zhou, Qi (bib0485) 2018; 1102-1103 Zhang, Song, Zhang (bib0465) 2018; 16 Ghosh, Loffredo, Mitra (bib0230) 2018; 25 Amberger, Hamosh (bib0235) 2017; 58 Clark, Rinker, Lessov (bib0420) 2000; 31 Wang, Lu, Du (bib0370) 2017; 13 Dai, Chen, Chen (bib0280) 2018; 2018 Chen, Lehmann, Meyer (bib0020) 2019; 9 Lv, Wang, Shen (bib0135) 2015; 115 Longa, Weinstein, Carlson (bib0210) 1989; 20 Gorsuch, Chrysanthou, Schwaeble (bib0055) 2012; 217 Orgah, Yu, Zhao (bib0220) 2018; 9 Zhang, Yu, Zhang (bib0300) 2018; 219 Zhang, Xing, Chang (bib0320) 2019; 10 Wardlaw, Murray, Berge (bib0015) 2012; 379 Liu, Jiang, Zhang (bib0340) 2019; 18 Yang, Wang, Shi (bib0025) 2019; 10 Liu, Zhu, Zou (bib0405) 2015; 51 Liu, Guo, Wang (bib0290) 2016; 6 Wang, Ren, Liu (bib0325) 2016; 2016 Baeuerle, Henkel (bib0180) 1994; 12 Kalogeris, Baines, Krenz (bib0040) 2017; 7 Huang, Xie, Yu (bib0270) 2018; 46 Wang, Zhou, Xu (bib0105) 2017; 2017 Kawabori, Yenari (bib0160) 2015; 22 Pawate, Shen, Fan (bib0390) 2004; 77 Peng, Jiang, Farhan (bib0155) 2019; 10 Han, Li, Ma (bib0070) 2017; 177 Zhang, Yu, Zhang (bib0100) 2018; 219 Fang, Huang, Chen (bib0285) 2008; 8 Fan, Liao, Pan (bib0010) 2019; 28 Lyu, Yan, Liu (bib0225) 2017; 7 Yu, Zhang, Zhang (bib0095) 2017; 7 Sun, Xu, Gao (bib0330) 2019; 22 Sun, Fan, Han (bib0065) 2015; 5 Han, Zhou, Xing (bib0310) 2015; 29 Shvedova, Anfinogenova, Atochina-Vasserman (bib0035) 2018; 9 Pan, Konstas, Bateman (bib0050) 2007; 49 Mizuma, Yenari (bib0060) 2017; 8 Brown, Hem, Katz (bib0240) 2015; 43 Shang, Zhang, Yao (bib0080) 2013; 2013 Lambertsen, Gregersen, Meldgaard (bib0395) 2004; 63 Ru, Li, Wang (bib0265) 2014; 6 Hyakkoku, Hamanaka, Tsuruma (bib0470) 2010; 171 Benjamin, Muntner, Alonso (bib0005) 2019; 139 Jin, Liu (bib0355) 2014; 11 Yamasaki, Matsuura, Shozuhara (bib0400) 1995; 26 Zhao, Chen, Xie (bib0190) 2018; 55 Caso, Pradillo, Hurtado (bib0475) 2007; 115 Li, Kostulas, Huang (bib0380) 2001; 116 Lin, He, Wu (bib0215) 1993; 24 Li (bib0365) 2013; 11 Zhou, Liesz, Bauer (bib0385) 2013; 23 Xiang, Xiao, Shen (bib0460) 2018; 95 Chen, Zhou, Liu (bib0275) 2006; 149 Chen, Guo, Yang (bib0120) 2015; 233 Han, Li, Pan (bib0085) 2019 Chen, Wei, Wang (bib0090) 2015; 9 Waje-Andreassen, Kråkenes, Ulvestad (bib0415) 2005; 111 Berti, Williams, Moffett (bib0425) 2002; 22 Yu, Wang, Wang (bib0245) 2018; 18 Ronaldson, Demarco, Sanchez-Covarrubias (bib0445) 2009; 29 Fishilevich, Nudel, Rappaport (bib0255) 2017; 2017 Kalogeris, Baines, Krenz (bib0045) 2012; 298 Koizumi, Yoshida, Nakazawa (bib0205) 1986; 8 Pang, Ye, Che (bib0450) 2001; 32 Jayaraj, Azimullah, Beiram (bib0165) 2019; 16 Morris, Wright, Tan (bib0200) 2016; 11 Bertrand, Dygert, Toborek (bib0195) 2017 Kim, Kawabori, Yenari (bib0175) 2014; 21 Hou, Zhao, Shen (bib0130) 2016; 17 DiSabato, Quan (bib0150) 2016; 139 Abdullahi, Tripathi (bib0345) 2018; 315 Chen, Liu, Pan (bib0145) 2018; 49 Yilmaz, Arumugam, Stokes (bib0375) 2006; 113 Zou, Zhang, Feng (bib0125) 2017; 14 Cao, Wang, Li (bib0075) 2017; 2017 Nurmi, Lindsberg, Koistinaho (bib0455) 2004; 35 Rappaport, Fishilevich, Nudel (bib0260) 2017; 16 Bergmann, Lawler, Qu (bib0490) 2018; 13 Wang, Dong, Li (bib0110) 2014; 339 Longa (10.1016/j.biopha.2020.109945_bib0210) 1989; 20 Xie (10.1016/j.biopha.2020.109945_bib0115) 2018; 7 Hyakkoku (10.1016/j.biopha.2020.109945_bib0470) 2010; 171 Rappaport (10.1016/j.biopha.2020.109945_bib0260) 2017; 16 Zhang (10.1016/j.biopha.2020.109945_bib0300) 2018; 219 Iadecola (10.1016/j.biopha.2020.109945_bib0440) 2011; 17 Kramer (10.1016/j.biopha.2020.109945_bib0315) 2014; 30 Zou (10.1016/j.biopha.2020.109945_bib0125) 2017; 14 Zheng (10.1016/j.biopha.2020.109945_bib0305) 2015; 2015 Gorsuch (10.1016/j.biopha.2020.109945_bib0055) 2012; 217 Lambertsen (10.1016/j.biopha.2020.109945_bib0170) 2012; 32 Berti (10.1016/j.biopha.2020.109945_bib0425) 2002; 22 Hou (10.1016/j.biopha.2020.109945_bib0130) 2016; 17 Han (10.1016/j.biopha.2020.109945_bib0085) 2019 Clark (10.1016/j.biopha.2020.109945_bib0420) 2000; 31 Peng (10.1016/j.biopha.2020.109945_bib0155) 2019; 10 Wang (10.1016/j.biopha.2020.109945_bib0370) 2017; 13 Lin (10.1016/j.biopha.2020.109945_bib0215) 1993; 24 Yoshimoto (10.1016/j.biopha.2020.109945_bib0410) 1997; 93 Lin (10.1016/j.biopha.2020.109945_bib0030) 2016; 5 Orgah (10.1016/j.biopha.2020.109945_bib0220) 2018; 9 Ronaldson (10.1016/j.biopha.2020.109945_bib0445) 2009; 29 Chen (10.1016/j.biopha.2020.109945_bib0090) 2015; 9 Yu (10.1016/j.biopha.2020.109945_bib0245) 2018; 18 Dobolyi (10.1016/j.biopha.2020.109945_bib0435) 2012; 13 Chen (10.1016/j.biopha.2020.109945_bib0020) 2019; 9 Ghosh (10.1016/j.biopha.2020.109945_bib0230) 2018; 25 Yuan (10.1016/j.biopha.2020.109945_bib0360) 2017; 22 Zhao (10.1016/j.biopha.2020.109945_bib0190) 2018; 55 Bertrand (10.1016/j.biopha.2020.109945_bib0195) 2017 Zhang (10.1016/j.biopha.2020.109945_bib0335) 2012; 201 Yilmaz (10.1016/j.biopha.2020.109945_bib0375) 2006; 113 Lambertsen (10.1016/j.biopha.2020.109945_bib0395) 2004; 63 Morris (10.1016/j.biopha.2020.109945_bib0200) 2016; 11 Pawate (10.1016/j.biopha.2020.109945_bib0390) 2004; 77 Ru (10.1016/j.biopha.2020.109945_bib0265) 2014; 6 He (10.1016/j.biopha.2020.109945_bib0185) 2017; 37 Shvedova (10.1016/j.biopha.2020.109945_bib0035) 2018; 9 Xiang (10.1016/j.biopha.2020.109945_bib0460) 2018; 95 Chen (10.1016/j.biopha.2020.109945_bib0480) 2019; 33 Koizumi (10.1016/j.biopha.2020.109945_bib0205) 1986; 8 Pang (10.1016/j.biopha.2020.109945_bib0450) 2001; 32 Han (10.1016/j.biopha.2020.109945_bib0310) 2015; 29 Qian (10.1016/j.biopha.2020.109945_bib0485) 2018; 1102-1103 Chen (10.1016/j.biopha.2020.109945_bib0275) 2006; 149 Liu (10.1016/j.biopha.2020.109945_bib0405) 2015; 51 Sun (10.1016/j.biopha.2020.109945_bib0065) 2015; 5 Benjamin (10.1016/j.biopha.2020.109945_bib0005) 2019; 139 Shang (10.1016/j.biopha.2020.109945_bib0080) 2013; 2013 Jayaraj (10.1016/j.biopha.2020.109945_bib0165) 2019; 16 Amberger (10.1016/j.biopha.2020.109945_bib0235) 2017; 58 Tang (10.1016/j.biopha.2020.109945_bib0140) 2010; 17 Fishilevich (10.1016/j.biopha.2020.109945_bib0255) 2017; 2017 Fang (10.1016/j.biopha.2020.109945_bib0285) 2008; 8 Bergmann (10.1016/j.biopha.2020.109945_bib0490) 2018; 13 Cao (10.1016/j.biopha.2020.109945_bib0075) 2017; 2017 Zhang (10.1016/j.biopha.2020.109945_bib0100) 2018; 219 Zhou (10.1016/j.biopha.2020.109945_bib0385) 2013; 23 Dai (10.1016/j.biopha.2020.109945_bib0280) 2018; 2018 Kim (10.1016/j.biopha.2020.109945_bib0175) 2014; 21 Pan (10.1016/j.biopha.2020.109945_bib0050) 2007; 49 Wardlaw (10.1016/j.biopha.2020.109945_bib0015) 2012; 379 Li (10.1016/j.biopha.2020.109945_bib0380) 2001; 116 Kim (10.1016/j.biopha.2020.109945_bib0295) 2019; 47 Lyu (10.1016/j.biopha.2020.109945_bib0225) 2017; 7 Sun (10.1016/j.biopha.2020.109945_bib0330) 2019; 22 Haddad (10.1016/j.biopha.2020.109945_bib0430) 2006; 149 Huang (10.1016/j.biopha.2020.109945_bib0270) 2018; 46 Li (10.1016/j.biopha.2020.109945_bib0365) 2013; 11 Chen (10.1016/j.biopha.2020.109945_bib0120) 2015; 233 Waje-Andreassen (10.1016/j.biopha.2020.109945_bib0415) 2005; 111 Lv (10.1016/j.biopha.2020.109945_bib0135) 2015; 115 Yamasaki (10.1016/j.biopha.2020.109945_bib0400) 1995; 26 Ghatge (10.1016/j.biopha.2020.109945_bib0250) 2018; 17 Kalogeris (10.1016/j.biopha.2020.109945_bib0040) 2017; 7 DiSabato (10.1016/j.biopha.2020.109945_bib0150) 2016; 139 Yu (10.1016/j.biopha.2020.109945_bib0095) 2017; 7 Caso (10.1016/j.biopha.2020.109945_bib0475) 2007; 115 Liu (10.1016/j.biopha.2020.109945_bib0340) 2019; 18 Jiang (10.1016/j.biopha.2020.109945_bib0350) 2018; 163-164 Wang (10.1016/j.biopha.2020.109945_bib0325) 2016; 2016 Brown (10.1016/j.biopha.2020.109945_bib0240) 2015; 43 Jin (10.1016/j.biopha.2020.109945_bib0355) 2014; 11 Fan (10.1016/j.biopha.2020.109945_bib0010) 2019; 28 Wang (10.1016/j.biopha.2020.109945_bib0105) 2017; 2017 Liu (10.1016/j.biopha.2020.109945_bib0290) 2016; 6 Zhang (10.1016/j.biopha.2020.109945_bib0320) 2019; 10 Nurmi (10.1016/j.biopha.2020.109945_bib0455) 2004; 35 Kalogeris (10.1016/j.biopha.2020.109945_bib0045) 2012; 298 Kawabori (10.1016/j.biopha.2020.109945_bib0160) 2015; 22 Wang (10.1016/j.biopha.2020.109945_bib0110) 2014; 339 Baeuerle (10.1016/j.biopha.2020.109945_bib0180) 1994; 12 Zhang (10.1016/j.biopha.2020.109945_bib0465) 2018; 16 Mizuma (10.1016/j.biopha.2020.109945_bib0060) 2017; 8 Chen (10.1016/j.biopha.2020.109945_bib0145) 2018; 49 Han (10.1016/j.biopha.2020.109945_bib0070) 2017; 177 Yang (10.1016/j.biopha.2020.109945_bib0025) 2019; 10 Abdullahi (10.1016/j.biopha.2020.109945_bib0345) 2018; 315 |
| References_xml | – volume: 2017 year: 2017 ident: bib0105 article-title: Astragaloside IV for experimental focal cerebral ischemia: preclinical evidence and possible mechanisms publication-title: Oxid. Med. Cell. Longev. – volume: 177 start-page: 146 year: 2017 end-page: 173 ident: bib0070 article-title: Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion publication-title: Pharmacol. Ther. – volume: 21 start-page: 2076 year: 2014 end-page: 2097 ident: bib0175 article-title: Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets publication-title: Curr. Med. Chem. – volume: 28 start-page: 220 year: 2019 end-page: 226 ident: bib0010 article-title: Intravenous Thrombolysis Is Safe and Effective for the Cryptogenic Stroke in China: Data From the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) publication-title: J. Stroke Cerebrovasc. Dis. – volume: 139 start-page: e56 year: 2019 end-page: e528 ident: bib0005 article-title: Heart disease and stroke Statistics-2019 update: a report from the american heart association publication-title: Circulation – volume: 51 start-page: 743 year: 2015 end-page: 752 ident: bib0405 article-title: Knockdown of IL-1β improves hypoxia-ischemia brain associated with IL-6 up-regulation in cell and animal models publication-title: Mol. Neurobiol. – volume: 20 start-page: 84 year: 1989 end-page: 91 ident: bib0210 article-title: Reversible middle cerebral artery occlusion without craniectomy in rats publication-title: Stroke. – volume: 9 start-page: 692 year: 2018 ident: bib0220 article-title: Danhong injection reversed cardiac abnormality in brain-heart syndrome via local and remote β-Adrenergic receptor signaling publication-title: Front. Pharmacol. – volume: 10 start-page: 1174 year: 2019 ident: bib0025 article-title: Herbal compatibility of ginseng and rhubarb exerts synergistic neuroprotection in cerebral Ischemia/Reperfusion injury of rats publication-title: Front. Physiol. – volume: 17 start-page: 1145 year: 2010 end-page: 1149 ident: bib0140 article-title: The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats publication-title: Phytomedicine. – volume: 22 start-page: 1324 year: 2019 end-page: 1327 ident: bib0330 article-title: Clinical observation in edaravone treatment for acute cerebral infarction publication-title: Niger. J. Clin. Pract. – volume: 35 start-page: 987 year: 2004 end-page: 991 ident: bib0455 article-title: Nuclear factor-kappaB contributes to infarction after permanent focal ischemia publication-title: Stroke – volume: 115 start-page: 1599 year: 2007 end-page: 1608 ident: bib0475 article-title: Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke publication-title: Circulation – start-page: 54805 year: 2017 ident: bib0195 article-title: Induction of ischemic stroke and ischemia-reperfusion in mice using the middle artery occlusion technique and visualization of infarct area publication-title: J. Vis. Exp. – volume: 113 start-page: 2105 year: 2006 end-page: 2112 ident: bib0375 article-title: Role of T lymphocytes and interferon-gamma in ischemic stroke publication-title: Circulation. – volume: 11 start-page: 254 year: 2014 end-page: 262 ident: bib0355 article-title: Liu W.EArly ischemic blood brain barrier damage: a potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis publication-title: Curr. Neurovasc. Res. – volume: 43 start-page: D36 year: 2015 end-page: D42 ident: bib0240 article-title: Gene: a gene-centered information resource at NCBI publication-title: Nucleic Acids Res. – volume: 233 start-page: 2823 year: 2015 end-page: 2831 ident: bib0120 article-title: Protective effect of ginsenoside Rb1 on integrity of blood-brain barrier following cerebral ischemia publication-title: Exp. Brain Res. – volume: 12 start-page: 141 year: 1994 end-page: 179 ident: bib0180 article-title: Function and activation of NF-kappa B in the immune system publication-title: Annu. Rev. Immunol. – volume: 7 start-page: 270 year: 2018 ident: bib0115 article-title: Protective effects and target network analysis of ginsenoside Rg1 in cerebral ischemia and reperfusion injury: a comprehensive overview of experimental studies publication-title: Cells – volume: 2016 year: 2016 ident: bib0325 article-title: An overview of systematic reviews of danhong injection for ischemic stroke publication-title: Evid. Complement. Alternat. Med. – volume: 149 start-page: 1092 year: 2006 end-page: 1103 ident: bib0275 article-title: Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation publication-title: Br. J. Pharmacol. – volume: 14 start-page: 6012 year: 2017 end-page: 6016 ident: bib0125 article-title: Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats publication-title: Exp. Ther. Med. – volume: 32 start-page: 1677 year: 2012 end-page: 1698 ident: bib0170 article-title: Inflammatory cytokines in experimental and human stroke publication-title: J. Cereb. Blood Flow Metab. – volume: 8 start-page: 58 year: 2008 ident: bib0285 article-title: TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining publication-title: BMC Complement. Altern. Med. – volume: 5 start-page: 8 year: 2015 end-page: 24 ident: bib0065 article-title: Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage publication-title: Acta Pharm. Sin. B – volume: 22 start-page: 1068 year: 2002 end-page: 1079 ident: bib0425 article-title: Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury publication-title: J. Cereb. Blood Flow Metab. – volume: 219 start-page: 288 year: 2018 end-page: 298 ident: bib0100 article-title: An integrated evidence-based targeting strategy for determining combinatorial bioactive ingredients of a compound herbal medicine Qishen Yiqi dripping pills publication-title: J. Ethnopharmacol. – volume: 49 start-page: 2211 year: 2018 end-page: 2219 ident: bib0145 article-title: Angioedema and hemorrhage after 4.5-Hour tPA (TissueType plasminogen activator) thrombolysis ameliorated by T541 via restoring brain microvascular integrity publication-title: Stroke – volume: 25 start-page: 16493 year: 2018 end-page: 16507 ident: bib0230 article-title: PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations publication-title: Environ. Sci. Pollut. Res. Int. – volume: 6 start-page: 13 year: 2014 ident: bib0265 article-title: TCMSP: a database of systems pharmacology for drug discovery from herbal medicines publication-title: J. Cheminform. – volume: 17 start-page: 1190 year: 2016 ident: bib0130 article-title: Neuroprotective effect of salvianolic acids against cerebral Ischemia/Reperfusion injury publication-title: Int. J. Mol. Sci. – volume: 217 start-page: 1026 year: 2012 end-page: 1033 ident: bib0055 article-title: The complement system in ischemia-reperfusion injuries publication-title: Immunobiology – volume: 298 start-page: 229 year: 2012 end-page: 317 ident: bib0045 article-title: Cell biology of Ischemia/Reperfusion injury publication-title: Int. Rev. Cell Mol. Biol. – volume: 29 start-page: 1612 year: 2015 end-page: 1618 ident: bib0310 article-title: Identification of NF-κB inhibitors in Qishenyiqi dropping pills for myocardial infarction treatment based on bioactivity-integrated UPLC-Q/TOF MS publication-title: Biomed. Chromatogr. – volume: 16 start-page: 184 year: 2018 end-page: 193 ident: bib0465 article-title: Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation publication-title: Chin. J. Nat. Med. – volume: 16 start-page: 142 year: 2019 ident: bib0165 article-title: Neuroinflammation: friend and foe for ischemic stroke publication-title: J. Neuroinflammation – volume: 116 start-page: 5 year: 2001 end-page: 14 ident: bib0380 article-title: IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat publication-title: J. Neuroimmunol. – volume: 93 start-page: 154 year: 1997 end-page: 158 ident: bib0410 article-title: Induction of cytokines, chemokines and adhesion molecule mRNA in a rat forebrain reperfusion model publication-title: Acta Neuropathol. – volume: 339 start-page: 144 year: 2014 end-page: 148 ident: bib0110 article-title: Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats publication-title: J. Neurol. Sci. – volume: 7 start-page: 113 year: 2017 end-page: 170 ident: bib0040 article-title: Ischemia/Reperfusion publication-title: Compr. Physiol. – volume: 49 start-page: 93 year: 2007 end-page: 102 ident: bib0050 article-title: Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies publication-title: Neuroradiology – volume: 149 start-page: 23 year: 2006 end-page: 30 ident: bib0430 article-title: Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice publication-title: Br. J. Pharmacol. – volume: 10 start-page: 1133 year: 2019 ident: bib0320 article-title: Efficacy and safety of NaoShuanTong Capsule in the treatment of ischemic stroke: a meta-analysis publication-title: Front. Pharmacol. – volume: 115 start-page: 30 year: 2015 end-page: 36 ident: bib0135 article-title: Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats publication-title: Brain Res. Bull. – volume: 22 start-page: 1135 year: 2017 ident: bib0360 article-title: How can synergism of traditional medicines benefit from network pharmacology publication-title: Molecules – volume: 7 start-page: 7353 year: 2017 ident: bib0095 article-title: A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi publication-title: Sci. Rep. – volume: 63 start-page: 942 year: 2004 end-page: 955 ident: bib0395 article-title: A role for interferon-gamma in focal cerebral ischemia in mice publication-title: J. Neuropathol. Exp. Neurol. – volume: 1102-1103 start-page: 34 year: 2018 end-page: 44 ident: bib0485 article-title: A UHPLC-QTOF-MS/MS method for the simultaneous determination of eight triterpene compounds from Poria cocos (Schw.) Wolf extract in rat plasma: application to a comparative pharmacokinetic study publication-title: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. – volume: 2018 year: 2018 ident: bib0280 article-title: A network pharmacology-based approach to investigate the novel TCM formula against huntington’s disease and validated by support vector machine model publication-title: Evid. Complement. Alternat. Med. – volume: 13 start-page: 2827 year: 2018 end-page: 2843 ident: bib0490 article-title: Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics publication-title: Nat. Protoc. – volume: 5 start-page: 213 year: 2016 ident: bib0030 article-title: Ischemia-reperfusion injury in the brain: mechanisms and potential therapeutic strategies publication-title: Biochem. Pharmacol. (Los Angel) – volume: 55 start-page: 4311 year: 2018 end-page: 4319 ident: bib0190 article-title: Suppression of TLR4/NF-κB Signaling Pathway Improves Cerebral Ischemia-Reperfusion Injury in Rats publication-title: Mol. Neurobiol. – volume: 47 start-page: D1102 year: 2019 end-page: D1109 ident: bib0295 article-title: PubChem 2019 update: improved access to chemical data publication-title: Nucleic Acids Res. – volume: 201 start-page: 297 year: 2012 end-page: 306 ident: bib0335 article-title: Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury publication-title: Neuroscience – volume: 32 start-page: 544 year: 2001 end-page: 552 ident: bib0450 article-title: Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-ss1 expression publication-title: Stroke – volume: 29 start-page: 1084 year: 2009 end-page: 1098 ident: bib0445 article-title: Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain publication-title: J. Cereb. Blood Flow Metab. – volume: 219 start-page: 288 year: 2018 end-page: 298 ident: bib0300 article-title: An integrated evidence-based targeting strategy for determining combinatorialbioactive ingredients of a compound herbal medicine Qishen Yiqi dripping pills publication-title: J. Ethnopharmacol. – volume: 10 start-page: 204 year: 2019 ident: bib0155 article-title: Anti-inflammatory effects of traditional chinese medicines on preclinical in vivo models of brain ischemia-reperfusion-Injury: prospects for neuroprotective drug discovery and therapy publication-title: Front. Pharmacol. – volume: 77 start-page: 540 year: 2004 end-page: 551 ident: bib0390 article-title: Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma publication-title: J. Neurosci. Res. – volume: 2013 year: 2013 ident: bib0080 article-title: Qi-shen-yi-qi dripping pills for the secondary prevention of myocardial infarction: a randomised clinical trial publication-title: Evid. Complement. Alternat. Med. – volume: 58 year: 2017 ident: bib0235 article-title: Searching online mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes publication-title: Curr. Protoc. Bioinformatics – volume: 26 start-page: 676 year: 1995 end-page: 680 ident: bib0400 article-title: Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats publication-title: Stroke – volume: 9 start-page: 304 year: 2019 end-page: 308 ident: bib0020 article-title: Timing of symptomatic intracerebral hemorrhage after rt-PA treatment in ischemic stroke publication-title: Neurol. Clin. Pract. – volume: 17 start-page: 796 year: 2011 end-page: 808 ident: bib0440 article-title: The immunology of stroke: from mechanisms to translation publication-title: Nat. Med. – volume: 315 start-page: C343 year: 2018 end-page: C356 ident: bib0345 article-title: Ronaldson PT.BLood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection publication-title: Am. J. Physiol., Cell Physiol. – volume: 24 start-page: 117 year: 1993 end-page: 121 ident: bib0215 article-title: Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats publication-title: Stroke – volume: 18 start-page: 292 year: 2018 ident: bib0245 article-title: Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis publication-title: BMC Complement. Altern. Med. – volume: 30 start-page: 523 year: 2014 end-page: 530 ident: bib0315 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics. – volume: 6 start-page: 21146 year: 2016 ident: bib0290 article-title: BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of traditional chinese medicine publication-title: Sci. Rep. – volume: 18 start-page: 2437 year: 2019 end-page: 2442 ident: bib0340 article-title: Protective effect of edaravone on blood-brain barrier by affecting NRF-2/HO-1 signaling pathway publication-title: Exp. Ther. Med. – volume: 8 start-page: 467 year: 2017 ident: bib0060 article-title: Anti-inflammatory targets for the treatment of reperfusion injury in stroke publication-title: Front. Neurol. – volume: 7 start-page: 15427 year: 2017 ident: bib0225 article-title: Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection publication-title: Sci. Rep. – volume: 2017 year: 2017 ident: bib0255 article-title: GeneHancer:genome-wide integration of enhancers and target genes in GeneCards publication-title: Database (Oxford). – volume: 22 start-page: 1258 year: 2015 end-page: 1277 ident: bib0160 article-title: Inflammatory responses in brain ischemia publication-title: Curr. Med. Chem. – volume: 11 year: 2016 ident: bib0200 article-title: A comparative study of variables influencing ischemic injury in the longa and koizumi methods of intraluminal filament middle cerebral artery occlusion in mice publication-title: PLoS One – volume: 2017 start-page: 7062714 year: 2017 ident: bib0075 article-title: Practice of comparative effectiveness research to identify treatment characteristics of similar chinese patent medicine for angina pectoris publication-title: Evid. Complement. Alternat. Med. – year: 2019 ident: bib0085 article-title: Effects and mechanisms of QiShenYiQi pills and major ingredients on myocardial microcirculatory disturbance, cardiac injury and fibrosis induced by ischemia-reperfusion publication-title: Pharmacol. Res. – volume: 16 start-page: 72 year: 2017 ident: bib0260 article-title: Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect publication-title: Biomed. Eng. Online – volume: 31 start-page: 1715 year: 2000 end-page: s ident: bib0420 article-title: Lack of interleukin-6 expression is not protective against focal central nervous system ischemia publication-title: Stroke – volume: 23 start-page: 34 year: 2013 end-page: 44 ident: bib0385 article-title: Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models publication-title: Brain Pathol. – volume: 37 start-page: 2938 year: 2017 end-page: 2951 ident: bib0185 article-title: Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling publication-title: J. Cereb. Blood Flow Metab. – volume: 2015 year: 2015 ident: bib0305 article-title: The mechanism research of Qishen Yiqi Formula by module-network analysis publication-title: Evid. Complement. Alternat. Med. – volume: 111 start-page: 360 year: 2005 end-page: 365 ident: bib0415 article-title: IL-6: an early marker for outcome in acute ischemic stroke publication-title: Acta Neurol. Scand. – volume: 9 start-page: 715 year: 2018 ident: bib0035 article-title: C-jun N-Terminal kinases (JNKs) in myocardial and cerebral Ischemia/Reperfusion injury publication-title: Front. Pharmacol. – volume: 11 start-page: 110 year: 2013 end-page: 120 ident: bib0365 article-title: Zhang B.TRaditional Chinese medicine network pharmacology: theory,methodology and application publication-title: Chin. J. Nat. Med. – volume: 171 start-page: 258 year: 2010 end-page: 267 ident: bib0470 article-title: Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia publication-title: Neuroscience – volume: 46 start-page: D1117 year: 2018 end-page: D1120 ident: bib0270 article-title: TCMID 2.0: a comprehensive resource for TCM publication-title: Nucleic Acids Res. – volume: 379 start-page: 2364 year: 2012 end-page: 2372 ident: bib0015 article-title: Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis publication-title: Lancet – volume: 139 start-page: 136 year: 2016 end-page: 153 ident: bib0150 article-title: Godbout JP.Neuroinflammation: the devil is in the details publication-title: J. Neurochem. – volume: 95 start-page: 39 year: 2018 end-page: 46 ident: bib0460 article-title: Anti-inflammatory effects of anisalcohol on lipopolysaccharide-stimulated BV2 microglia via selective modulation of microglia polarization and down-regulation of NF-κB p65 and JNK activation publication-title: Mol. Immunol. – volume: 33 start-page: e4585 year: 2019 ident: bib0480 article-title: Validated UHPLC-MS/MS method for simultaneous determination of four triterpene saponins from Akebia trifoliata extract in rat plasma and its application to a pharmacokinetic study publication-title: Biomed. Chromatogr. – volume: 163-164 start-page: 144 year: 2018 end-page: 171 ident: bib0350 article-title: Blood-brain barrier dysfunction and recovery after ischemic stroke publication-title: Prog. Neurobiol. – volume: 9 start-page: 3051 year: 2015 end-page: 3066 ident: bib0090 article-title: Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions publication-title: Drug Des. Devel. Ther. – volume: 13 start-page: 1018 year: 2017 end-page: 1030 ident: bib0370 article-title: An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis publication-title: Mol. Biosyst. – volume: 17 start-page: 4253 year: 2018 end-page: 4264 ident: bib0250 article-title: Integrative gene ontology and network analysis of coronary artery disease associated genes suggests potential role of ErbB pathway gene EGFR publication-title: Mol. Med. Rep. – volume: 8 start-page: 1 year: 1986 end-page: 8 ident: bib0205 article-title: Experimental studies of ischemic brain edema 1.a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area publication-title: Jpn J Stroke – volume: 13 start-page: 8219 year: 2012 end-page: 8258 ident: bib0435 article-title: The neuroprotective functions of transforming growth factor beta proteins publication-title: Int. J. Mol. Sci. – volume: 7 start-page: 15427 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0225 article-title: Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection publication-title: Sci. Rep. doi: 10.1038/s41598-017-14692-3 – volume: 115 start-page: 30 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0135 article-title: Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2015.05.002 – volume: 25 start-page: 16493 issue: 17 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0230 article-title: PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-017-0149-1 – volume: 16 start-page: 184 issue: 3 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0465 article-title: Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation publication-title: Chin. J. Nat. Med. – volume: 9 start-page: 3051 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0090 article-title: Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions publication-title: Drug Des. Devel. Ther. doi: 10.2147/DDDT.S82146 – volume: 8 start-page: 467 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0060 article-title: Anti-inflammatory targets for the treatment of reperfusion injury in stroke publication-title: Front. Neurol. doi: 10.3389/fneur.2017.00467 – volume: 16 start-page: 72 issue: Suppl 1 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0260 article-title: Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect publication-title: Biomed. Eng. Online doi: 10.1186/s12938-017-0359-2 – volume: 17 start-page: 1145 issue: 14 year: 2010 ident: 10.1016/j.biopha.2020.109945_bib0140 article-title: The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats publication-title: Phytomedicine. doi: 10.1016/j.phymed.2010.03.017 – volume: 9 start-page: 715 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0035 article-title: C-jun N-Terminal kinases (JNKs) in myocardial and cerebral Ischemia/Reperfusion injury publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.00715 – volume: 379 start-page: 2364 issue: 9834 year: 2012 ident: 10.1016/j.biopha.2020.109945_bib0015 article-title: Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis publication-title: Lancet doi: 10.1016/S0140-6736(12)60738-7 – volume: 2017 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0255 article-title: GeneHancer:genome-wide integration of enhancers and target genes in GeneCards publication-title: Database (Oxford). doi: 10.1093/database/bax028 – volume: 9 start-page: 692 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0220 article-title: Danhong injection reversed cardiac abnormality in brain-heart syndrome via local and remote β-Adrenergic receptor signaling publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.00692 – volume: 93 start-page: 154 issue: 2 year: 1997 ident: 10.1016/j.biopha.2020.109945_bib0410 article-title: Induction of cytokines, chemokines and adhesion molecule mRNA in a rat forebrain reperfusion model publication-title: Acta Neuropathol. doi: 10.1007/s004010050596 – volume: 219 start-page: 288 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0300 article-title: An integrated evidence-based targeting strategy for determining combinatorialbioactive ingredients of a compound herbal medicine Qishen Yiqi dripping pills publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2018.02.041 – volume: 37 start-page: 2938 issue: 8 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0185 article-title: Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling publication-title: J. Cereb. Blood Flow Metab. doi: 10.1177/0271678X16679671 – volume: 14 start-page: 6012 issue: 6 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0125 article-title: Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats publication-title: Exp. Ther. Med. – volume: 32 start-page: 544 issue: 2 year: 2001 ident: 10.1016/j.biopha.2020.109945_bib0450 article-title: Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-ss1 expression publication-title: Stroke doi: 10.1161/01.STR.32.2.544 – volume: 201 start-page: 297 year: 2012 ident: 10.1016/j.biopha.2020.109945_bib0335 article-title: Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury publication-title: Neuroscience doi: 10.1016/j.neuroscience.2011.11.005 – volume: 26 start-page: 676 issue: 4 year: 1995 ident: 10.1016/j.biopha.2020.109945_bib0400 article-title: Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats publication-title: Stroke doi: 10.1161/01.STR.26.4.676 – volume: 217 start-page: 1026 issue: 11 year: 2012 ident: 10.1016/j.biopha.2020.109945_bib0055 article-title: The complement system in ischemia-reperfusion injuries publication-title: Immunobiology doi: 10.1016/j.imbio.2012.07.024 – volume: 7 start-page: 7353 issue: 1 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0095 article-title: A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi publication-title: Sci. Rep. doi: 10.1038/s41598-017-07659-x – volume: 11 start-page: 110 issue: 2 year: 2013 ident: 10.1016/j.biopha.2020.109945_bib0365 article-title: Zhang B.TRaditional Chinese medicine network pharmacology: theory,methodology and application publication-title: Chin. J. Nat. Med. doi: 10.3724/SP.J.1009.2013.00110 – volume: 13 start-page: 2827 issue: 12 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0490 article-title: Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics publication-title: Nat. Protoc. doi: 10.1038/s41596-018-0066-x – volume: 63 start-page: 942 issue: 9 year: 2004 ident: 10.1016/j.biopha.2020.109945_bib0395 article-title: A role for interferon-gamma in focal cerebral ischemia in mice publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/63.9.942 – year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0085 article-title: Effects and mechanisms of QiShenYiQi pills and major ingredients on myocardial microcirculatory disturbance, cardiac injury and fibrosis induced by ischemia-reperfusion publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2019.104386 – volume: 2016 year: 2016 ident: 10.1016/j.biopha.2020.109945_bib0325 article-title: An overview of systematic reviews of danhong injection for ischemic stroke publication-title: Evid. Complement. Alternat. Med. – volume: 177 start-page: 146 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0070 article-title: Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2017.03.005 – volume: 116 start-page: 5 year: 2001 ident: 10.1016/j.biopha.2020.109945_bib0380 article-title: IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat publication-title: J. Neuroimmunol. doi: 10.1016/S0165-5728(01)00264-8 – volume: 20 start-page: 84 issue: 1 year: 1989 ident: 10.1016/j.biopha.2020.109945_bib0210 article-title: Reversible middle cerebral artery occlusion without craniectomy in rats publication-title: Stroke. doi: 10.1161/01.STR.20.1.84 – volume: 29 start-page: 1084 issue: 6 year: 2009 ident: 10.1016/j.biopha.2020.109945_bib0445 article-title: Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2009.32 – volume: 5 start-page: 8 issue: 1 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0065 article-title: Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2014.11.002 – volume: 17 start-page: 796 issue: 7 year: 2011 ident: 10.1016/j.biopha.2020.109945_bib0440 article-title: The immunology of stroke: from mechanisms to translation publication-title: Nat. Med. doi: 10.1038/nm.2399 – volume: 6 start-page: 13 year: 2014 ident: 10.1016/j.biopha.2020.109945_bib0265 article-title: TCMSP: a database of systems pharmacology for drug discovery from herbal medicines publication-title: J. Cheminform. doi: 10.1186/1758-2946-6-13 – volume: 7 start-page: 113 issue: 1 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0040 article-title: Ischemia/Reperfusion publication-title: Compr. Physiol. doi: 10.1002/j.2040-4603.2017.tb00741.x – volume: 2018 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0280 article-title: A network pharmacology-based approach to investigate the novel TCM formula against huntington’s disease and validated by support vector machine model publication-title: Evid. Complement. Alternat. Med. – volume: 77 start-page: 540 issue: 4 year: 2004 ident: 10.1016/j.biopha.2020.109945_bib0390 article-title: Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma publication-title: J. Neurosci. Res. doi: 10.1002/jnr.20180 – volume: 149 start-page: 23 issue: 1 year: 2006 ident: 10.1016/j.biopha.2020.109945_bib0430 article-title: Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0706837 – volume: 8 start-page: 58 year: 2008 ident: 10.1016/j.biopha.2020.109945_bib0285 article-title: TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining publication-title: BMC Complement. Altern. Med. doi: 10.1186/1472-6882-8-58 – volume: 339 start-page: 144 issue: 1-2 year: 2014 ident: 10.1016/j.biopha.2020.109945_bib0110 article-title: Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2014.02.002 – volume: 13 start-page: 1018 issue: 5 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0370 article-title: An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis publication-title: Mol. Biosyst. doi: 10.1039/C7MB00003K – volume: 11 start-page: 254 issue: 3 year: 2014 ident: 10.1016/j.biopha.2020.109945_bib0355 article-title: Liu W.EArly ischemic blood brain barrier damage: a potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis publication-title: Curr. Neurovasc. Res. doi: 10.2174/1567202611666140530145643 – volume: 29 start-page: 1612 issue: 10 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0310 article-title: Identification of NF-κB inhibitors in Qishenyiqi dropping pills for myocardial infarction treatment based on bioactivity-integrated UPLC-Q/TOF MS publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.3468 – volume: 5 start-page: 213 issue: 4 year: 2016 ident: 10.1016/j.biopha.2020.109945_bib0030 article-title: Ischemia-reperfusion injury in the brain: mechanisms and potential therapeutic strategies publication-title: Biochem. Pharmacol. (Los Angel) – volume: 233 start-page: 2823 issue: 10 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0120 article-title: Protective effect of ginsenoside Rb1 on integrity of blood-brain barrier following cerebral ischemia publication-title: Exp. Brain Res. doi: 10.1007/s00221-015-4352-3 – volume: 18 start-page: 292 issue: 1 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0245 article-title: Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis publication-title: BMC Complement. Altern. Med. doi: 10.1186/s12906-018-2356-9 – volume: 113 start-page: 2105 issue: 17 year: 2006 ident: 10.1016/j.biopha.2020.109945_bib0375 article-title: Role of T lymphocytes and interferon-gamma in ischemic stroke publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.105.593046 – volume: 115 start-page: 1599 issue: 12 year: 2007 ident: 10.1016/j.biopha.2020.109945_bib0475 article-title: Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.603431 – start-page: 54805 issue: 120 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0195 article-title: Induction of ischemic stroke and ischemia-reperfusion in mice using the middle artery occlusion technique and visualization of infarct area publication-title: J. Vis. Exp. – volume: 22 start-page: 1324 issue: Oct 10 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0330 article-title: Clinical observation in edaravone treatment for acute cerebral infarction publication-title: Niger. J. Clin. Pract. doi: 10.4103/njcp.njcp_367_18 – volume: 315 start-page: C343 issue: 3 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0345 article-title: Ronaldson PT.BLood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection publication-title: Am. J. Physiol., Cell Physiol. doi: 10.1152/ajpcell.00095.2018 – volume: 139 start-page: e56 issue: 10 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0005 article-title: Heart disease and stroke Statistics-2019 update: a report from the american heart association publication-title: Circulation doi: 10.1161/CIR.0000000000000659 – volume: 111 start-page: 360 issue: 6 year: 2005 ident: 10.1016/j.biopha.2020.109945_bib0415 article-title: IL-6: an early marker for outcome in acute ischemic stroke publication-title: Acta Neurol. Scand. doi: 10.1111/j.1600-0404.2005.00416.x – volume: 43 start-page: D36 issue: Database issue year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0240 article-title: Gene: a gene-centered information resource at NCBI publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1055 – volume: 139 start-page: 136 issue: Suppl 2 year: 2016 ident: 10.1016/j.biopha.2020.109945_bib0150 article-title: Godbout JP.Neuroinflammation: the devil is in the details publication-title: J. Neurochem. doi: 10.1111/jnc.13607 – volume: 13 start-page: 8219 issue: 7 year: 2012 ident: 10.1016/j.biopha.2020.109945_bib0435 article-title: The neuroprotective functions of transforming growth factor beta proteins publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms13078219 – volume: 298 start-page: 229 year: 2012 ident: 10.1016/j.biopha.2020.109945_bib0045 article-title: Cell biology of Ischemia/Reperfusion injury publication-title: Int. Rev. Cell Mol. Biol. doi: 10.1016/B978-0-12-394309-5.00006-7 – volume: 16 start-page: 142 issue: 1 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0165 article-title: Neuroinflammation: friend and foe for ischemic stroke publication-title: J. Neuroinflammation doi: 10.1186/s12974-019-1516-2 – volume: 47 start-page: D1102 issue: D1 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0295 article-title: PubChem 2019 update: improved access to chemical data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1033 – volume: 33 start-page: e4585 issue: 10 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0480 article-title: Validated UHPLC-MS/MS method for simultaneous determination of four triterpene saponins from Akebia trifoliata extract in rat plasma and its application to a pharmacokinetic study publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.4585 – volume: 24 start-page: 117 issue: 1 year: 1993 ident: 10.1016/j.biopha.2020.109945_bib0215 article-title: Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats publication-title: Stroke doi: 10.1161/01.STR.24.1.117 – volume: 2017 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0105 article-title: Astragaloside IV for experimental focal cerebral ischemia: preclinical evidence and possible mechanisms publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2017/8424326 – volume: 17 start-page: 4253 issue: 3 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0250 article-title: Integrative gene ontology and network analysis of coronary artery disease associated genes suggests potential role of ErbB pathway gene EGFR publication-title: Mol. Med. Rep. – volume: 2013 year: 2013 ident: 10.1016/j.biopha.2020.109945_bib0080 article-title: Qi-shen-yi-qi dripping pills for the secondary prevention of myocardial infarction: a randomised clinical trial publication-title: Evid. Complement. Alternat. Med. – volume: 55 start-page: 4311 issue: 5 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0190 article-title: Suppression of TLR4/NF-κB Signaling Pathway Improves Cerebral Ischemia-Reperfusion Injury in Rats publication-title: Mol. Neurobiol. doi: 10.1007/s12035-017-0552-0 – volume: 17 start-page: 1190 issue: 7 year: 2016 ident: 10.1016/j.biopha.2020.109945_bib0130 article-title: Neuroprotective effect of salvianolic acids against cerebral Ischemia/Reperfusion injury publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms17071190 – volume: 149 start-page: 1092 issue: 8 year: 2006 ident: 10.1016/j.biopha.2020.109945_bib0275 article-title: Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0706945 – volume: 51 start-page: 743 issue: 2 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0405 article-title: Knockdown of IL-1β improves hypoxia-ischemia brain associated with IL-6 up-regulation in cell and animal models publication-title: Mol. Neurobiol. doi: 10.1007/s12035-014-8764-z – volume: 22 start-page: 1135 issue: 7 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0360 article-title: How can synergism of traditional medicines benefit from network pharmacology publication-title: Molecules doi: 10.3390/molecules22071135 – volume: 171 start-page: 258 issue: 1 year: 2010 ident: 10.1016/j.biopha.2020.109945_bib0470 article-title: Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.08.054 – volume: 46 start-page: D1117 issue: D1 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0270 article-title: TCMID 2.0: a comprehensive resource for TCM publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx1028 – volume: 23 start-page: 34 issue: 1 year: 2013 ident: 10.1016/j.biopha.2020.109945_bib0385 article-title: Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models publication-title: Brain Pathol. doi: 10.1111/j.1750-3639.2012.00614.x – volume: 2017 start-page: 7062714 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0075 article-title: Practice of comparative effectiveness research to identify treatment characteristics of similar chinese patent medicine for angina pectoris publication-title: Evid. Complement. Alternat. Med. doi: 10.1155/2017/7062714 – volume: 30 start-page: 523 issue: 4 year: 2014 ident: 10.1016/j.biopha.2020.109945_bib0315 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics. doi: 10.1093/bioinformatics/btt703 – volume: 2015 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0305 article-title: The mechanism research of Qishen Yiqi Formula by module-network analysis publication-title: Evid. Complement. Alternat. Med. – volume: 49 start-page: 2211 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0145 article-title: Angioedema and hemorrhage after 4.5-Hour tPA (TissueType plasminogen activator) thrombolysis ameliorated by T541 via restoring brain microvascular integrity publication-title: Stroke doi: 10.1161/STROKEAHA.118.021754 – volume: 18 start-page: 2437 issue: 4 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0340 article-title: Protective effect of edaravone on blood-brain barrier by affecting NRF-2/HO-1 signaling pathway publication-title: Exp. Ther. Med. – volume: 28 start-page: 220 issue: 1 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0010 article-title: Intravenous Thrombolysis Is Safe and Effective for the Cryptogenic Stroke in China: Data From the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2018.09.041 – volume: 9 start-page: 304 issue: 4 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0020 article-title: Timing of symptomatic intracerebral hemorrhage after rt-PA treatment in ischemic stroke publication-title: Neurol. Clin. Pract. doi: 10.1212/CPJ.0000000000000632 – volume: 163-164 start-page: 144 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0350 article-title: Blood-brain barrier dysfunction and recovery after ischemic stroke publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2017.10.001 – volume: 49 start-page: 93 issue: 2 year: 2007 ident: 10.1016/j.biopha.2020.109945_bib0050 article-title: Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies publication-title: Neuroradiology doi: 10.1007/s00234-006-0183-z – volume: 11 issue: 2 year: 2016 ident: 10.1016/j.biopha.2020.109945_bib0200 article-title: A comparative study of variables influencing ischemic injury in the longa and koizumi methods of intraluminal filament middle cerebral artery occlusion in mice publication-title: PLoS One doi: 10.1371/journal.pone.0148503 – volume: 21 start-page: 2076 issue: 18 year: 2014 ident: 10.1016/j.biopha.2020.109945_bib0175 article-title: Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets publication-title: Curr. Med. Chem. doi: 10.2174/0929867321666131228205146 – volume: 6 start-page: 21146 year: 2016 ident: 10.1016/j.biopha.2020.109945_bib0290 article-title: BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of traditional chinese medicine publication-title: Sci. Rep. doi: 10.1038/srep21146 – volume: 35 start-page: 987 issue: 4 year: 2004 ident: 10.1016/j.biopha.2020.109945_bib0455 article-title: Nuclear factor-kappaB contributes to infarction after permanent focal ischemia publication-title: Stroke doi: 10.1161/01.STR.0000120732.45951.26 – volume: 12 start-page: 141 year: 1994 ident: 10.1016/j.biopha.2020.109945_bib0180 article-title: Function and activation of NF-kappa B in the immune system publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.iy.12.040194.001041 – volume: 10 start-page: 1133 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0320 article-title: Efficacy and safety of NaoShuanTong Capsule in the treatment of ischemic stroke: a meta-analysis publication-title: Front. Pharmacol. doi: 10.3389/fphar.2019.01133 – volume: 22 start-page: 1258 issue: 10 year: 2015 ident: 10.1016/j.biopha.2020.109945_bib0160 article-title: Inflammatory responses in brain ischemia publication-title: Curr. Med. Chem. doi: 10.2174/0929867322666150209154036 – volume: 32 start-page: 1677 issue: 9 year: 2012 ident: 10.1016/j.biopha.2020.109945_bib0170 article-title: Inflammatory cytokines in experimental and human stroke publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2012.88 – volume: 219 start-page: 288 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0100 article-title: An integrated evidence-based targeting strategy for determining combinatorial bioactive ingredients of a compound herbal medicine Qishen Yiqi dripping pills publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2018.02.041 – volume: 22 start-page: 1068 issue: 9 year: 2002 ident: 10.1016/j.biopha.2020.109945_bib0425 article-title: Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury publication-title: J. Cereb. Blood Flow Metab. doi: 10.1097/00004647-200209000-00004 – volume: 8 start-page: 1 year: 1986 ident: 10.1016/j.biopha.2020.109945_bib0205 article-title: Experimental studies of ischemic brain edema 1.a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area publication-title: Jpn J Stroke doi: 10.3995/jstroke.8.1 – volume: 58 year: 2017 ident: 10.1016/j.biopha.2020.109945_bib0235 article-title: Searching online mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes publication-title: Curr. Protoc. Bioinformatics doi: 10.1002/cpbi.27 – volume: 31 start-page: 1715 issue: 7 year: 2000 ident: 10.1016/j.biopha.2020.109945_bib0420 article-title: Lack of interleukin-6 expression is not protective against focal central nervous system ischemia publication-title: Stroke doi: 10.1161/01.STR.31.7.1715 – volume: 95 start-page: 39 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0460 article-title: Anti-inflammatory effects of anisalcohol on lipopolysaccharide-stimulated BV2 microglia via selective modulation of microglia polarization and down-regulation of NF-κB p65 and JNK activation publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2018.01.011 – volume: 1102-1103 start-page: 34 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0485 article-title: A UHPLC-QTOF-MS/MS method for the simultaneous determination of eight triterpene compounds from Poria cocos (Schw.) Wolf extract in rat plasma: application to a comparative pharmacokinetic study publication-title: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2018.10.011 – volume: 7 start-page: 270 issue: 12 year: 2018 ident: 10.1016/j.biopha.2020.109945_bib0115 article-title: Protective effects and target network analysis of ginsenoside Rg1 in cerebral ischemia and reperfusion injury: a comprehensive overview of experimental studies publication-title: Cells doi: 10.3390/cells7120270 – volume: 10 start-page: 1174 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0025 article-title: Herbal compatibility of ginseng and rhubarb exerts synergistic neuroprotection in cerebral Ischemia/Reperfusion injury of rats publication-title: Front. Physiol. doi: 10.3389/fphys.2019.01174 – volume: 10 start-page: 204 year: 2019 ident: 10.1016/j.biopha.2020.109945_bib0155 article-title: Anti-inflammatory effects of traditional chinese medicines on preclinical in vivo models of brain ischemia-reperfusion-Injury: prospects for neuroprotective drug discovery and therapy publication-title: Front. Pharmacol. doi: 10.3389/fphar.2019.00204 |
| SSID | ssj0005638 |
| Score | 2.5385551 |
| Snippet | [Display omitted]
Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the... Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 109945 |
| SubjectTerms | Animals Blood-Brain Barrier - pathology Brain Edema - pathology Brain Ischemia - prevention & control Cerebral ischemia/reperfusion injury Disease Models, Animal Drugs, Chinese Herbal - pharmacology Inflammation - drug therapy Inflammation - physiopathology Ischemic Stroke - prevention & control Male Mice Mice, Inbred ICR Neuroinflammatory response Neuroprotective Agents - pharmacology QiShenYiQi Reperfusion Injury - drug therapy Reperfusion Injury - physiopathology RNA, Messenger - metabolism TCM-based network pharmacology Transforming Growth Factor beta1 - genetics |
| Title | Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0753332220301359 https://dx.doi.org/10.1016/j.biopha.2020.109945 https://www.ncbi.nlm.nih.gov/pubmed/32028240 https://www.proquest.com/docview/2352640068 |
| Volume | 125 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED9KB2MvY-u-snVFg9GnenEkf8iPpaxkGy0pbaF7EpIidSqNE9KkkJf-7buz7HSDjY492pEcW3e-O_nu9zuAj9x6Z4VJEymFSdDj20Q6oxMtPbeuGucDTQDno-NieJ59vcgvNuCgw8JQWWVr-6NNb6x1e6bfrmZ_FkL_FJ2dEJQooKhe5ATiy7KStPzT3S9lHkXTzZoGJzS6g881NV4mTImUiWPMRLxKFYGa_uye_hZ-Nm7o8Bk8beNHth9v8TlsuHoLHh-1GfIt2B1FLurVHju7h1bd7LFdNrpnqV69gNtRZGhAuTB9qQOGiUzb5cIx6-aUTb5mAXe-bhKIQ2rm5n5JH9ZYqK9QDMys2Ek4_eHq7-EksNugWcOMifqKKjZpUvd4pikxZ5MpVeBGvOdLOD_8fHYwTNomDInNeblAM-21HBSpx42kHujU2QJ3aUamvrR5yXOLxzZ3aeUrtAVWSF651HltqaUNOmDxCjbrae3eAMPlFSUf488Z2g1uTFEOMj-WJceLGT3ugejWXtmWoZwaZVyrrhTtSkWJKZKYihLrQbKeNYsMHQ-Mzzuxqg59ivZSoQt5YF65nvebhv7DzA-d9ih8eSkjo2s3Xd4oTt0JMoLp9OB1VKv1M1Bje4nx1tv__t938ISOYnnmNmwu5kv3HkOohdlp3pEdeLT_5dvw-CexXx2- |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTxsxEB5RkNpeKqCvtEBdqeLENhvv-4gQKLQEBREkerJsx26NyCYKCVIu_e2dWe8GkKioelw_9uEZz4x3Zr4B-MK1NTpSYZDnkQpQ4-sgN0oGMrdcm2KYdCQlOPdO0-5F_O0yuVyBgyYXhsIqa9nvZXolreuWdr2a7Ylz7XNUdlFEjgKy6qOkeAZrMW5fKmPw9fe9OI-0KmdNowMa3uTPVUFeyo0JlYmj0UTASgVlNT2un_5mf1Z66GgdXtUGJNv377gBK6bchOe92kW-Cbt9D0a92GODu9yqmz22y_p3MNWL13Db9xANSBgmf0qHdiKTej4zTJspuZOvmcOjrxk5ApGamKmd05815sorpANTC3bmzn-Z8oc7c-zWSVZBYyLDIo-NKt89tlQx5mw0phBcn_D5Bi6ODgcH3aCuwhDohGczlNNW5p00tHiSlB0ZGp3iMU3loc10kvFE47VOTFjYAoWBRgIUJjRWaqppgxo4egur5bg074Hh8kYZH2J3jIKDK5VmndgO84zjzZQctiBq1l7oGqKcKmVciyYW7Up4igmimPAUa0GwnDXxEB1PjE8asoom_RQFpkAd8sS8bDnvAYv-w8zPDfcI3L3kkpGlGc9vBKfyBDHl6bTgnWer5TdQZfscDa4P__3cT_CiO-idiJPj0-8f4SX1-FjNLVidTedmG-2pmdqp9ssfA7gfTA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Protection+against+acute+cerebral+ischemia%2Freperfusion+injury+by+QiShenYiQi+via+neuroinflammatory+network+mobilization&rft.jtitle=Biomedicine+%26+pharmacotherapy&rft.au=Wang%2C+Yule&rft.au=Xiao%2C+Guangxu&rft.au=He%2C+Shuang&rft.au=Liu%2C+Xinyan&rft.date=2020-05-01&rft.issn=0753-3322&rft.volume=125&rft.spage=109945&rft_id=info:doi/10.1016%2Fj.biopha.2020.109945&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_biopha_2020_109945 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0753-3322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0753-3322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0753-3322&client=summon |