Development and characterization of chimera of yellow fever virus vaccine strain and Tick-Borne encephalitis virus

Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus va...

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Published inPloS one Vol. 18; no. 5; p. e0284823
Main Authors Kuznetsova, Nadezhda, Siniavin, Andrei, Butenko, Alexander, Larichev, Victor, Kozlova, Alina, Usachev, Evgeny, Nikiforova, Maria, Usacheva, Olga, Shchetinin, Alexey, Pochtovyi, Andrei, Shidlovskaya, Elena, Odintsova, Alina, Belyaeva, Elizaveta, Voskoboinikov, Aleksander, Bessonova, Arina, Vasilchenko, Lyudmila, Karganova, Galina, Zlobin, Vladimir, Logunov, Denis, Gushchin, Vladimir, Gintsburg, Alexander
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 10.05.2023
Subjects
Animals
Antibodies
Arachnids
Biology and Life Sciences
Care and treatment
Cell culture
Central nervous system
Cloning
Complications and side effects
Cytomegalovirus
Dengue fever
Diagnosis
Encephalitis
Encephalitis Viruses, Tick-Borne
Encephalitis, Tick-Borne
Fever
Genomes
Humans
Hybrid structures
Immunoglobulins
Invasiveness
Mammalian cells
Mammals
Medicine and Health Sciences
Mice
Neurotropism
Neurovirulence
Pathogens
Research and Analysis Methods
Severe acute respiratory syndrome coronavirus 2
Tick-borne encephalitis
Vaccines
Vector-borne diseases
Vectors (Biology)
Viral Vaccines
Viruses
West Nile virus
Yellow fever
Yellow Fever Vaccine - genetics
Yellow fever virus - genetics
Zika virus
Russia
United Kingdom > UK
United States > US
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Abstract Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 107-106 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
AbstractList Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 10 7 −10 6 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 107−106 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 10.sup.7 -10.sup.6 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 107-106 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 10 7 −10 6 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
Audience Academic
Author Butenko, Alexander
Siniavin, Andrei
Usacheva, Olga
Gushchin, Vladimir
Vasilchenko, Lyudmila
Voskoboinikov, Aleksander
Usachev, Evgeny
Kozlova, Alina
Shchetinin, Alexey
Karganova, Galina
Kuznetsova, Nadezhda
Larichev, Victor
Shidlovskaya, Elena
Logunov, Denis
Belyaeva, Elizaveta
Nikiforova, Maria
Odintsova, Alina
Zlobin, Vladimir
Gintsburg, Alexander
Pochtovyi, Andrei
Bessonova, Arina
AuthorAffiliation 5 Institute for Translational Medicine and Biotechnology, Sechenov University, Moscow, Russia
4 Laboratory of Biology of Arboviruses, FSASI Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of RAS, Moscow, Russia
University of Pécs: Pecsi Tudomanyegyetem, HUNGARY
6 Department of Infectiology and Virology, Federal State Autonomous Educational Institution of Higher Education I M Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
2 Department of Molecular Neuroimmune Signalling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
1 Federal State Budgetary Institution "National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya" of the Ministry of Health of the Russian Federation, Moscow, Russia
3 Department of Virology, Lomonosov Moscow State University, Moscow, Ru
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  organization: Department of Infectiology and Virology, Federal State Autonomous Educational Institution of Higher Education I M Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37163522$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1128/JVI.73.4.3095-3101.1999
10.1016/S0264-410X(03)00488-2
10.1073/pnas.89.21.10532
10.1093/infdis/jiq003
10.1586/erv.11.7
10.1371/journal.pone.0159564
10.1517/14712598.2012.704908
10.1128/JVI.79.13.8602-8613.2005
10.1093/oxfordjournals.aje.a118408
10.1016/j.ttbdis.2022.101972
10.1016/j.antiviral.2019.01.014
10.1038/s41586-020-3035-9
10.1016/j.vaccine.2014.02.046
10.1128/JVI.78.22.12497-12507.2004
10.1371/journal.pone.0059347
10.1080/21645515.2019.1658503
10.1086/649916
10.1038/s41598-018-31375-9
10.1016/j.vaccine.2007.12.015
10.1128/JVI.02255-09
10.1016/j.vaccine.2014.10.004
10.1038/s41541-018-0092-2
10.1073/pnas.95.4.1746
10.4269/ajtmh.2001.65.405
10.1016/j.vaccine.2012.08.063
10.1016/j.vaccine.2013.12.050
10.1016/j.vaccine.2016.11.062
10.1586/14760584.2016.1123097
10.1016/j.virol.2005.12.001
10.1073/pnas.022652799
10.1016/j.vaccine.2005.07.067
10.1128/JVI.74.7.3020-3028.2000
10.1099/vir.0.068023-0
10.1006/viro.2000.0426
ContentType Journal Article
Copyright Copyright: © 2023 Kuznetsova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COPYRIGHT 2023 Public Library of Science
2023 Kuznetsova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 Kuznetsova et al 2023 Kuznetsova et al
2023 Kuznetsova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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– notice: 2023 Kuznetsova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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– notice: 2023 Kuznetsova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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References H-J Wang (pone.0284823.ref036) 2014; 32
VA Jenkins (pone.0284823.ref003) 2022; 13
M Giel-Moloney (pone.0284823.ref013) 2018; 8
SS Whitehead (pone.0284823.ref032) 2003; 21
R Biedenbender (pone.0284823.ref011) 2011
K Chokephaibulkit (pone.0284823.ref005) 2016; 15
SB Halstead (pone.0284823.ref006) 2011; 10
Central Research Institute (pone.0284823.ref025) 2017
CY Huang (pone.0284823.ref034) 2000; 74
J-S Driouich (pone.0284823.ref022) 2019; 11
LJ Reed (pone.0284823.ref027) 1938
MC Bonaldo (pone.0284823.ref017) 2010; 84
F Aubry (pone.0284823.ref021) 2014; 95
TP Monath (pone.0284823.ref020) 2015; 33
MB Appaiahgari (pone.0284823.ref004) 2012; 12
AG Pletnev (pone.0284823.ref031) 2002; 99
AA Rumyantsev (pone.0284823.ref039) 2006; 24
SJ Thomas (pone.0284823.ref008) 2019; 15
TJ Chambers (pone.0284823.ref029) 1999; 73
AG Pletnev (pone.0284823.ref030) 1998; 95
J Arroyo (pone.0284823.ref010) 2004; 78
D Ruzek (pone.0284823.ref001) 2019; 164
T Chotpitayasunondh (pone.0284823.ref007) 2017; 35
L Sanchez-Felipe (pone.0284823.ref019) 2021; 590
OV Morozova (pone.0284823.ref026) 2014; 32
RT Nogueira (pone.0284823.ref016) 2013; 8
AG Pletnev (pone.0284823.ref035) 2000; 274
AG Pletnev (pone.0284823.ref037) 1992; 89
AP Durbin (pone.0284823.ref033) 2001; 65
PF Wright (pone.0284823.ref028) 2008; 26
D Morrison (pone.0284823.ref040) 2010; 201
M Kubinski (pone.0284823.ref038) 2020; 8
SM Ali (pone.0284823.ref023) 2018; 13
pone.0284823.ref002
DB Kum (pone.0284823.ref014) 2018; 3
PJ Bredenbeek (pone.0284823.ref018) 2006; 345
B Guy (pone.0284823.ref009) 2017; 16
GH Dayan (pone.0284823.ref012) 2012; 30
MC Bonaldo (pone.0284823.ref015) 2005; 79
L de Fabritus (pone.0284823.ref024) 2016; 11
References_xml – volume: 73
  start-page: 3095
  year: 1999
  ident: pone.0284823.ref029
  article-title: Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties
  publication-title: J Virol
  doi: 10.1128/JVI.73.4.3095-3101.1999
  contributor:
    fullname: TJ Chambers
– volume: 21
  start-page: 4307
  year: 2003
  ident: pone.0284823.ref032
  article-title: Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys
  publication-title: Vaccine
  doi: 10.1016/S0264-410X(03)00488-2
  contributor:
    fullname: SS Whitehead
– volume: 89
  start-page: 10532
  year: 1992
  ident: pone.0284823.ref037
  article-title: Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.89.21.10532
  contributor:
    fullname: AG Pletnev
– start-page: 75
  year: 2011
  ident: pone.0284823.ref011
  article-title: Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Investigate the Immunogenicity and Safety of a West Nile Virus Vaccine in Healthy Adults
  publication-title: The Journal of Infectious Diseases
  doi: 10.1093/infdis/jiq003
  contributor:
    fullname: R Biedenbender
– volume: 13
  year: 2018
  ident: pone.0284823.ref023
  article-title: Comparison of chikungunya viruses generated using infectious clone or the Infectious Subgenomic Amplicons (ISA) method in Aedes mosquitoes
  publication-title: PLoS One
  contributor:
    fullname: SM Ali
– volume: 11
  year: 2019
  ident: pone.0284823.ref022
  article-title: Reverse Genetics of RNA Viruses: ISA-Based Approach to Control Viral Population Diversity without Modifying Virus Phenotype
  publication-title: Viruses
  contributor:
    fullname: J-S Driouich
– volume: 10
  start-page: 355
  year: 2011
  ident: pone.0284823.ref006
  article-title: New Japanese encephalitis vaccines: alternatives to production in mouse brain
  publication-title: Expert Rev Vaccines
  doi: 10.1586/erv.11.7
  contributor:
    fullname: SB Halstead
– volume: 11
  year: 2016
  ident: pone.0284823.ref024
  article-title: Utilisation of ISA Reverse Genetics and Large-Scale Random Codon Re-Encoding to Produce Attenuated Strains of Tick-Borne Encephalitis Virus within Days
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0159564
  contributor:
    fullname: L de Fabritus
– volume: 12
  start-page: 1251
  year: 2012
  ident: pone.0284823.ref004
  article-title: Clinical development of IMOJEV ®—a recombinant Japanese encephalitis chimeric vaccine (JE-CV)
  publication-title: Expert Opin Biol Ther
  doi: 10.1517/14712598.2012.704908
  contributor:
    fullname: MB Appaiahgari
– volume: 79
  start-page: 8602
  year: 2005
  ident: pone.0284823.ref015
  article-title: Attenuation of recombinant yellow fever 17D viruses expressing foreign protein epitopes at the surface
  publication-title: J Virol
  doi: 10.1128/JVI.79.13.8602-8613.2005
  contributor:
    fullname: MC Bonaldo
– start-page: 493
  year: 1938
  ident: pone.0284823.ref027
  article-title: A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12
  publication-title: American Journal of Epidemiology
  doi: 10.1093/oxfordjournals.aje.a118408
  contributor:
    fullname: LJ Reed
– volume: 13
  start-page: 101972
  year: 2022
  ident: pone.0284823.ref003
  article-title: The epidemiology of infectious diseases in Europe in 2020 versus 2017–2019 and the rise of tick-borne encephalitis (1995–2020)
  publication-title: Ticks Tick Borne Dis
  doi: 10.1016/j.ttbdis.2022.101972
  contributor:
    fullname: VA Jenkins
– volume: 164
  start-page: 23
  year: 2019
  ident: pone.0284823.ref001
  article-title: Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines
  publication-title: Antiviral Res
  doi: 10.1016/j.antiviral.2019.01.014
  contributor:
    fullname: D Ruzek
– volume: 16
  start-page: 1
  year: 2017
  ident: pone.0284823.ref009
  article-title: A recombinant live attenuated tetravalent vaccine for the prevention of dengue
  publication-title: Expert Rev Vaccines
  contributor:
    fullname: B Guy
– volume: 590
  start-page: 320
  year: 2021
  ident: pone.0284823.ref019
  article-title: A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
  publication-title: Nature
  doi: 10.1038/s41586-020-3035-9
  contributor:
    fullname: L Sanchez-Felipe
– volume: 8
  year: 2020
  ident: pone.0284823.ref038
  article-title: Tick-Borne Encephalitis Virus: A Quest for Better Vaccines against a Virus on the Rise
  publication-title: Vaccines (Basel)
  contributor:
    fullname: M Kubinski
– volume: 32
  year: 2014
  ident: pone.0284823.ref026
  article-title: Evaluation of immune response and protective effect of four vaccines against the tick-borne encephalitis virus
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2014.02.046
  contributor:
    fullname: OV Morozova
– volume: 78
  start-page: 12497
  year: 2004
  ident: pone.0284823.ref010
  article-title: ChimeriVax-West Nile virus live-attenuated vaccine: preclinical evaluation of safety, immunogenicity, and efficacy
  publication-title: J Virol
  doi: 10.1128/JVI.78.22.12497-12507.2004
  contributor:
    fullname: J Arroyo
– volume: 8
  start-page: e59347
  year: 2013
  ident: pone.0284823.ref016
  article-title: Recombinant yellow fever viruses elicit CD8+ T cell responses and protective immunity against Trypanosoma cruzi
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0059347
  contributor:
    fullname: RT Nogueira
– volume: 15
  start-page: 2295
  year: 2019
  ident: pone.0284823.ref008
  article-title: A review of Dengvaxia®: development to deployment
  publication-title: Hum Vaccin Immunother
  doi: 10.1080/21645515.2019.1658503
  contributor:
    fullname: SJ Thomas
– ident: pone.0284823.ref002
– volume: 201
  start-page: 370
  year: 2010
  ident: pone.0284823.ref040
  article-title: A novel tetravalent dengue vaccine is well tolerated and immunogenic against all 4 serotypes in flavivirus-naive adults
  publication-title: J Infect Dis
  doi: 10.1086/649916
  contributor:
    fullname: D Morrison
– volume: 8
  start-page: 13206
  year: 2018
  ident: pone.0284823.ref013
  article-title: Chimeric yellow fever 17D-Zika virus (ChimeriVax-Zika) as a live-attenuated Zika virus vaccine
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-31375-9
  contributor:
    fullname: M Giel-Moloney
– volume: 26
  start-page: 882
  year: 2008
  ident: pone.0284823.ref028
  article-title: Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2007.12.015
  contributor:
    fullname: PF Wright
– volume: 84
  start-page: 3699
  year: 2010
  ident: pone.0284823.ref017
  article-title: Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques
  publication-title: J Virol
  doi: 10.1128/JVI.02255-09
  contributor:
    fullname: MC Bonaldo
– start-page: 2336
  year: 2017
  ident: pone.0284823.ref025
  article-title: ESTABLISHMENT OF PLAQUE ASSAY METHOD FOR TITRATING YELLOW FEVER VACCINE
  publication-title: International Journal of Advanced Research
  contributor:
    fullname: Central Research Institute
– volume: 33
  start-page: 62
  year: 2015
  ident: pone.0284823.ref020
  article-title: Live virus vaccines based on a yellow fever vaccine backbone: standardized template with key considerations for a risk/benefit assessment
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2014.10.004
  contributor:
    fullname: TP Monath
– volume: 3
  start-page: 56
  year: 2018
  ident: pone.0284823.ref014
  article-title: A yellow fever-Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-018-0092-2
  contributor:
    fullname: DB Kum
– volume: 95
  start-page: 1746
  year: 1998
  ident: pone.0284823.ref030
  article-title: Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.95.4.1746
  contributor:
    fullname: AG Pletnev
– volume: 65
  start-page: 405
  year: 2001
  ident: pone.0284823.ref033
  article-title: Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3’-untranslated region
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.2001.65.405
  contributor:
    fullname: AP Durbin
– volume: 30
  start-page: 6656
  year: 2012
  ident: pone.0284823.ref012
  article-title: Phase II, dose ranging study of the safety and immunogenicity of single dose West Nile vaccine in healthy adults ≥ 50 years of age
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.08.063
  contributor:
    fullname: GH Dayan
– volume: 32
  start-page: 949
  year: 2014
  ident: pone.0284823.ref036
  article-title: Recombinant chimeric Japanese encephalitis virus/tick-borne encephalitis virus is attenuated and protective in mice
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2013.12.050
  contributor:
    fullname: H-J Wang
– volume: 35
  start-page: 299
  year: 2017
  ident: pone.0284823.ref007
  article-title: Post-licensure, phase IV, safety study of a live attenuated Japanese encephalitis recombinant vaccine in children in Thailand
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2016.11.062
  contributor:
    fullname: T Chotpitayasunondh
– volume: 15
  start-page: 153
  year: 2016
  ident: pone.0284823.ref005
  article-title: Safety and immunogenicity of a live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®) in children
  publication-title: Expert Rev Vaccines
  doi: 10.1586/14760584.2016.1123097
  contributor:
    fullname: K Chokephaibulkit
– volume: 345
  start-page: 299
  year: 2006
  ident: pone.0284823.ref018
  article-title: A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins
  publication-title: Virology
  doi: 10.1016/j.virol.2005.12.001
  contributor:
    fullname: PJ Bredenbeek
– volume: 99
  start-page: 3036
  year: 2002
  ident: pone.0284823.ref031
  article-title: West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.022652799
  contributor:
    fullname: AG Pletnev
– volume: 24
  start-page: 133
  year: 2006
  ident: pone.0284823.ref039
  article-title: Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeys
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2005.07.067
  contributor:
    fullname: AA Rumyantsev
– volume: 74
  start-page: 3020
  year: 2000
  ident: pone.0284823.ref034
  article-title: Chimeric dengue type 2 (vaccine strain PDK-53)/dengue type 1 virus as a potential candidate dengue type 1 virus vaccine
  publication-title: J Virol
  doi: 10.1128/JVI.74.7.3020-3028.2000
  contributor:
    fullname: CY Huang
– volume: 95
  start-page: 2462
  year: 2014
  ident: pone.0284823.ref021
  article-title: Single-stranded positive-sense RNA viruses generated in days using infectious subgenomic amplicons
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.068023-0
  contributor:
    fullname: F Aubry
– volume: 274
  start-page: 26
  year: 2000
  ident: pone.0284823.ref035
  article-title: Chimeric Langat/Dengue viruses protect mice from heterologous challenge with the highly virulent strains of tick-borne encephalitis virus
  publication-title: Virology
  doi: 10.1006/viro.2000.0426
  contributor:
    fullname: AG Pletnev
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Snippet Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in...
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SubjectTerms Animals
Antibodies
Arachnids
Biology and Life Sciences
Care and treatment
Cell culture
Central nervous system
Cloning
Complications and side effects
Cytomegalovirus
Dengue fever
Diagnosis
Encephalitis
Encephalitis Viruses, Tick-Borne
Encephalitis, Tick-Borne
Fever
Genomes
Humans
Hybrid structures
Immunoglobulins
Invasiveness
Mammalian cells
Mammals
Medicine and Health Sciences
Mice
Neurotropism
Neurovirulence
Pathogens
Research and Analysis Methods
Severe acute respiratory syndrome coronavirus 2
Tick-borne encephalitis
Vaccines
Vector-borne diseases
Vectors (Biology)
Viral Vaccines
Viruses
West Nile virus
Yellow fever
Yellow Fever Vaccine - genetics
Yellow fever virus - genetics
Zika virus
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Title Development and characterization of chimera of yellow fever virus vaccine strain and Tick-Borne encephalitis virus
URI https://www.ncbi.nlm.nih.gov/pubmed/37163522
https://www.proquest.com/docview/2811920817/abstract/
https://search.proquest.com/docview/2812507515
https://pubmed.ncbi.nlm.nih.gov/PMC10171666
http://dx.doi.org/10.1371/journal.pone.0284823
Volume 18
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