Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects

• Published in: Movement disorders Vol. 29; no. 8; pp. 991 - 998
• Main Authors: Gray, Madison T., Munoz, David G., Gray, Douglas A., Schlossmacher, Michael G., Woulfe, John M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2014; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; alpha-Synuclein - analysis; alpha-Synuclein - metabolism; Antigens, CD - metabolism; Antigens, CD34 - metabolism; Antigens, Differentiation, Myelomonocytic - metabolism; enteric nervous system; Gastric Mucosa - metabolism; Gastrointestinal Tract - metabolism; Humans; Macrophages - metabolism; Middle Aged; Movement disorders; mucosal plexus; Nerve Fibers - metabolism; Parkinson's disease; Synaptophysin - metabolism; Ubiquitin Thiolesterase - metabolism; Vasoactive Intestinal Peptide - metabolism; vermiform appendix; α-synuclein; vermiform appendix; Parkinson's disease; enteric nervous system; mucosal plexus; α-synuclein

ABSTRACT Parkinson's disease is characterized by the pathological aggregation of Alpha‐synuclein. The dual‐hit hypothesis proposed by Braak implicates the enteric nervous system as an initial site of α‐synuclein aggregation with subsequent spread to the central nervous system. Regional variatio...