Exposure-Response Analysis of Sonidegib (LDE225), an Oral Inhibitor of the Hedgehog Signaling Pathway, for Effectiveness and Safety in Patients With Advanced Solid Tumors
Sonidegib selectively inhibits smoothened protein, suppresses the growth of Hedgehog pathway-dependent tumors, and has recently been approved in the indication of locally advanced basal cell carcinoma. A comprehensive exposure-response analysis was conducted to further characterize the relationship...
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Published in | Journal of clinical pharmacology Vol. 56; no. 11; p. 1406 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
01.11.2016
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Subjects | |
Online Access | Get more information |
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