The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells

• Published in: The journal of clinical endocrinology and metabolism Vol. 100; no. 10; pp. E1280 - E1288
• Main Authors: Rice, Gregory E, Scholz-Romero, Katherin, Sweeney, Emma, Peiris, Hassendrini, Kobayashi, Miharu, Duncombe, Gregory, Mitchell, Murray D, Salomon, Carlos
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.10.2015; Copyright by The Endocrine Society
• Subjects: Cytokines - metabolism; Exosomes - drug effects; Exosomes - metabolism; Female; Glucose - pharmacology; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Pregnancy; Pregnancy Trimester, First - metabolism; Trophoblasts - drug effects; Trophoblasts - metabolism

Context: Hyperglycemia and hypoxia are risk factors of metabolic complication during pregnancy. The interactions between oxygen and glucose-sensing pathways that regulate exosome bioactivity from placental cells, however, have not been established. Objective: The aim of this study was to test the hy...