Early molecular assessment of osseointegration in humans

• Published in: Clinical oral implants research Vol. 25; no. 11; pp. 1273 - 1285
• Main Authors: Thalji, Ghadeer N., Nares, Salvador, Cooper, Lyndon F.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.11.2014; Wiley Subscription Services, Inc
• Subjects: Adherent cells; Aged; Amino Acid Transport Systems, Neutral - genetics; Angiogenesis; Antigens, CD20 - genetics; Biological activity; Biomarkers - analysis; biomaterials; Biomechanics; bone implant interactions; Bone implants; Bone-Implant Interface - anatomy & histology; CCL18 protein; Chemokines, CC - genetics; Collagen; Collagen - genetics; Dental Implants; Dental Materials - chemistry; Dental Prosthesis Design; DNA microarrays; Extracellular matrix; Extracellular Matrix - genetics; Female; Fibrillogenesis; Gene expression; Gene Expression Profiling - methods; Gene regulation; Genomes; Humans; Immune response; Immune system; Immunomodulation; Implantation; Inflammation; Macrophage Activation - genetics; Macrophages; Male; Membrane Proteins - genetics; Middle Aged; Neovascularization, Physiologic - genetics; Nerve Tissue Proteins - genetics; Osseointegration; Osseointegration - genetics; Physical properties; Receptors, Immunologic - genetics; Ribonucleic acid; RNA; Scavenger Receptors, Class A - genetics; Surface Properties; Surgical implants; Titanium - chemistry; Topography; Topology; Transcription; Transcription, Genetic - genetics; wound healing; wound healing; bone implant interactions; biomaterials

Objective To determine the early temporal‐wide genome transcription regulation by the surface topography at the bone–implant interface of implants bearing microroughened or superimposed nanosurface topology. Materials and methods Four commercially pure titanium implants (2.2 × 5.0 mm) with either a...