Reactive Hyperemia Occurs Via Activation of Inwardly Rectifying Potassium Channels and Na+/K+-ATPase in Humans

• Published in: Circulation research Vol. 113; no. 8; pp. 1023 - 1032
• Main Authors: Crecelius, Anne R., Richards, Jennifer C., Luckasen, Gary J., Larson, Dennis G., Dinenno, Frank A.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 27.09.2013
• Subjects: Adolescent; Adult; Analysis of Variance; Blood Flow Velocity; Brachial Artery - drug effects; Brachial Artery - enzymology; Brachial Artery - physiopathology; Case-Control Studies; Cyclooxygenase Inhibitors - administration & dosage; Endothelium, Vascular - enzymology; Endothelium, Vascular - physiopathology; Female; Forearm - blood supply; Hemodynamics - drug effects; Humans; Hyperemia - enzymology; Hyperemia - physiopathology; Infusions, Intra-Arterial; Male; Microcirculation; Nitric Oxide - metabolism; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase - metabolism; Plethysmography; Potassium Channel Blockers - administration & dosage; Potassium Channels, Inwardly Rectifying - antagonists & inhibitors; Potassium Channels, Inwardly Rectifying - metabolism; Prostaglandins - metabolism; Regional Blood Flow; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors; Sodium-Potassium-Exchanging ATPase - metabolism; Time Factors; Vasodilation; Vasodilator Agents - administration & dosage; Young Adult; hyperpolarization; blood flow regulation; vasodilation; ischemia

RATIONALE:Reactive hyperemia (RH) in the forearm circulation is an important marker of cardiovascular health, yet the underlying vasodilator signaling pathways are controversial and thus remain unclear. OBJECTIVE:We hypothesized that RH occurs via activation of inwardly rectifying potassium (KIR) ch...