Vertical sleeve gastrectomy improves indices of metabolic disease in rodent model of surgical menopause

• Published in: Menopause (New York, N.Y.) Vol. 24; no. 4; p. 426
• Main Authors: Lawson, William J, Shirey, Kristin, Spann, Redin A, Zamarripa, Carlos A, Hosler, Jonathan P, Grayson, Bernadette E
• Format: Journal Article
• Language: English
• Published: United States 01.04.2017
• Subjects: Adenosine Triphosphate - biosynthesis; Adiposity; Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Bariatric Surgery - methods; Blood Glucose - metabolism; Disease Models, Animal; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - pathology; Female; Gastrectomy - methods; Liver - metabolism; Liver - pathology; Menopause; Mitochondria, Liver - metabolism; Obesity - complications; Obesity - metabolism; Obesity - surgery; Ovariectomy; Rats; Rats, Long-Evans; Triglycerides - metabolism; Weight Loss

Although women are the most common recipients of weight loss surgeries for the amelioration of the comorbidities of obesity, few studies have addressed the efficacy of these procedures with specific attention to reproductive stage. Here we ask in a rodent model of vertical sleeve gastrectomy (VSG) w...