Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging

• Published in: Neuroscience Vol. 474; pp. 63 - 79
• Main Authors: Benveniste, Helene, Lee, Hedok, Ozturk, Burhan, Chen, Xinan, Koundal, Sunil, Vaska, Paul, Tannenbaum, Allen, Volkow, Nora D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 15.10.2021
• Subjects: cerebrospinal fluid; gadolinium; glymphatic; lymphatic; magnetic resonance imaging; positron emission tomography; VFA-SPGR; magnetic resonance imaging; DCE-MRI; TSC; CNS; MW; ER; CSF; cerebrospinal fluid; glymphatic; positron emission tomography; ISF; PET; gadolinium; lymphatic

•DCE-MRI is a robust imaging platform for quantifying glymphatic transport.•Glymphatic transport and CSF flow dynamics is dependent on body posture.•T1 mapping can quantify glymphatic transport and cervical lymph node drainage concurrently.•Glymphatic transport kinetics are heterogenous across brain...