Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease

• Published in: Journal of gastroenterology and hepatology Vol. 27; no. s2; pp. 89 - 93
• Main Author: Gao, Bin
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.03.2012
• Subjects: alcoholic liver disease; Animals; Anti-Inflammatory Agents - therapeutic use; Cytokines - metabolism; Cytokines - therapeutic use; Cytoprotection; Humans; Immunity, Innate - drug effects; Inflammation Mediators - metabolism; interleukin-10; Interleukin-10 - metabolism; Interleukin-22; interleukin-6; Interleukin-6 - metabolism; Interleukins - metabolism; Interleukins - therapeutic use; Kupffer Cells - drug effects; Kupffer Cells - immunology; Liver - drug effects; Liver - immunology; Liver - pathology; Liver Diseases, Alcoholic - drug therapy; Liver Diseases, Alcoholic - immunology; Liver Diseases, Alcoholic - pathology; STAT3 Transcription Factor - metabolism; Treatment Outcome

The activation of innate immunity by various factors (e.g. lipopolysaccharide and complements) plays an important role in initiating and promoting alcoholic liver injury via the stimulation of Kupffer cells to induce oxidative stress and to produce pro‐inflammatory cytokines (e.g. tumor necrosis fac...