Prediction of in vitro response to interferon‐α in renal cell carcinoma cell lines

• Published in: Cancer science Vol. 98; no. 4; pp. 529 - 534
• Main Authors: Shimazui, Toru, Ami, Yoshihiro, Yoshikawa, Kazuhiro, Uchida, Kazuhiko, Kojima, Takahiro, Oikawa, Takehiro, Nakamura, Kogenta, Honda, Nobuaki, Hinotsu, Shiro, Miyazaki, Jun, Kunita, Noriko, Akaza, Hideyuki
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.04.2007
• Subjects: Antineoplastic Agents - pharmacology; Carcinoma, Renal Cell - drug therapy; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Interferon alpha-2; Interferon-alpha - pharmacology; Kidney Neoplasms - drug therapy; Models, Genetic; Original; Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger - analysis; Tumor Cells, Cultured

We analyzed the correlation between interferon‐α (IFNα) response and gene expression profiles to predict IFNα sensitivity and identified key molecules regulating the IFNα response in renal cell carcinoma (RCC) cell lines. To classify eight RCC cell lines of the SKRC series into three subgroups accor...