Targeting the conserved coronavirus octamer motif GGAAGAGC is a strategy for the development of coronavirus vaccine

• Published in: Virology journal Vol. 20; no. 1; p. 267
• Main Authors: Lin, Ching-Hung, Hsieh, Feng-Cheng, Chang, Yu-Chia, Yang, Cheng-Yao, Hsu, Hsuan-Wei, Yang, Chun-Chun, Tam, Hon-Man-Herman, Wu, Hung-Yi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.11.2023; BioMed Central; BMC
• Subjects: 3' Untranslated regions; Animals; Biological response modifiers; Cell culture; Cells, Cultured; Coronaviridae; Coronavirus; Coronavirus octamer; Coronaviruses; COVID-19 Vaccines; Disease control; Gene expression; Genomes; Health aspects; Hepatitis; Histopathology; Humans; Identification and classification; Immune response; Infections; Interferon; interferons; Interferons - genetics; Laboratory animals; Medical research; Medicine, Experimental; Mice; Multiplicity of infection; Murine hepatitis virus; Murine hepatitis virus - genetics; mutants; Mutation; Phenotypes; Proteins; Replication; Respiratory diseases; RNA; SARS-CoV-2 - genetics; Severe acute respiratory syndrome coronavirus 2; Structure; survival rate; Translation; Vaccine; Vaccine development; Vaccines; Viruses; weight loss; Western blotting; Taiwan; United States > US; Replication; Translation; Vaccine; Coronavirus; Coronavirus octamer

Coronaviruses are pathogens of humans and animals that cause widespread and costly diseases. The development of effective strategies to combat the threat of coronaviruses is therefore a top priority. The conserved coronavirus octamer motif 5'GGAAGAGC3' exists in the 3' untranslated re...