Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease

• Published in: American journal of respiratory and critical care medicine Vol. 186; no. 11; pp. 1117 - 1124
• Main Authors: Mallia, Patrick, Footitt, Joseph, Sotero, Rosa, Jepson, Annette, Contoli, Marco, Trujillo-Torralbo, Maria-Belen, Kebadze, Tatiana, Aniscenko, Julia, Oleszkiewicz, Gregory, Gray, Katrina, Message, Simon D., Ito, Kazuhiro, Barnes, Peter J., Adcock, Ian M., Papi, Alberto, Stanciu, Luminita A., Elkin, Sarah L., Kon, Onn M., Johnson, Malcolm, Johnston, Sebastian L.
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 01.12.2012
• Subjects: Adult; Aged; Airway management; Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antimicrobial Cationic Peptides - metabolism; Bacterial infections; Bacterial Infections - etiology; Bacterial Infections - physiopathology; Biological and medical sciences; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, asthma; Cohort Studies; Coinfection - etiology; Coinfection - physiopathology; Disease Progression; Elafin - analysis; Elafin - metabolism; Female; Humans; Hypotheses; Inflammation Mediators - analysis; Intensive care medicine; Male; Medical sciences; Middle Aged; Neutrophils; Peptides; Picornaviridae Infections - complications; Picornaviridae Infections - physiopathology; Pneumology; Polymerase chain reaction; Polymerase Chain Reaction - methods; Prognosis; Prospective Studies; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - microbiology; Pulmonary Disease, Chronic Obstructive - virology; Rhinovirus; Risk Assessment; Secretory Leukocyte Peptidase Inhibitor - analysis; Secretory Leukocyte Peptidase Inhibitor - metabolism; Serum Amyloid P-Component - analysis; Serum Amyloid P-Component - metabolism; Severity of Illness Index; Smoking; Sputum - cytology; Statistics, Nonparametric; Streptococcus infections; Viruses; United Kingdom > UK; Lung disease; disease exacerbation; Intensive care; bacteria; Respiratory disease; Picornaviridae; Virus; Infection; Bacteriosis; Bronchus disease; Chronic obstructive pulmonary disease; Resuscitation; Rhinovirus

Chronic obstructive pulmonary disease (COPD) exacerbations are associated with virus (mostly rhinovirus) and bacterial infections, but it is not known whether rhinovirus infections precipitate secondary bacterial infections. To investigate relationships between rhinovirus infection and bacterial inf...