Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease - Mallia, Patrick; Footitt, Joseph; Sotero, Rosa; Jepson, Annette; Contoli, Marco; Trujillo-Torralbo, Maria-Belen; Kebadze, Tatiana; Aniscenko, Julia; Oleszkiewicz, Gregory; Gray, Katrina; Message, Simon D.; Ito, Kazuhiro; et al. (American journal of respiratory and critical care medicine, 2012)
Keywords: Adult; Aged; Airway management; Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antimicrobial Cationic Peptides - metabolism; Bacterial infections; Bacterial Infections - etiology; Bacterial Infections - physiopathology; Biological and medical sciences; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, asthma; Cohort Studies; Coinfection - etiology; Coinfection - physiopathology; Disease Progression; Elafin - analysis; Elafin - metabolism; Female; Humans; Hypotheses; Inflammation Mediators - analysis; Intensive care medicine; Male; Medical sciences; Middle Aged; Neutrophils; Peptides; Picornaviridae Infections - complications; Picornaviridae Infections - physiopathology; Pneumology; Polymerase chain reaction; Polymerase Chain Reaction - methods; Prognosis; Prospective Studies; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - microbiology; Pulmonary Disease, Chronic Obstructive - virology; Rhinovirus; Risk Assessment; Secretory Leukocyte Peptidase Inhibitor - analysis; Secretory Leukocyte Peptidase Inhibitor - metabolism; Serum Amyloid P-Component - analysis; Serum Amyloid P-Component - metabolism; Severity of Illness Index; Smoking; Sputum - cytology; Statistics, Nonparametric; Streptococcus infections; Viruses; United Kingdom--UK; Lung disease; disease exacerbation; Intensive care; bacteria; Respiratory disease; Picornaviridae; Virus; Infection; Bacteriosis; Bronchus disease; Chronic obstructive pulmonary disease; Resuscitation; Rhinovirus