Changes in Poly(ADP-Ribosyl)ation Patterns in Workers Exposed to BTX

• Published in: PloS one Vol. 9; no. 9; p. e106146
• Main Authors: Sha, Yan, Zhou, Wei, Yang, Zhenyu, Zhu, Xiaoling, Xiang, Yingping, Li, Tiandi, Zhu, Dexiang, Yang, Xinyue
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2014; Public Library of Science (PLoS)
• Subjects: Aberration; Acute myeloid leukemia; Adenosine diphosphate; ADP-ribosylation; Adult; Airborne sensing; Benzene; Benzene - poisoning; Biology and Life Sciences; Cancer; Case-Control Studies; Chemical compounds; Chromatography; Containers; CpG islands; Cytokinesis; Cytokinesis - drug effects; Cytotoxicity; Damage detection; Deoxyribonucleic acid; Disease prevention; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA damage; DNA methylation; DNA-Binding Proteins - metabolism; DNMT1 protein; Employment; Environmental monitoring; Enzymes; Exposure; Family medical history; Female; Gene expression; Hematologic Tests; Hematology; Humans; Hydrocarbons; Leukemia; Lymphocytes; Male; Medicine and Health Sciences; Metabolism; Metabolites; Methylation; Micronuclei, Chromosome-Defective - drug effects; Myeloid leukemia; Occupational diseases; Occupational exposure; Occupational Exposure - adverse effects; Occupational hazards; Occupational health; Poisoning; Poly Adenosine Diphosphate Ribose - metabolism; Poly(ADP-ribose); Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerase 1; Poly(ADP-ribose) Polymerases - metabolism; Real-Time Polymerase Chain Reaction; Ribose; RNA, Messenger - genetics; RNA, Messenger - metabolism; Studies; Toluene; Toluene - poisoning; Toxicity; Workforce; Xylene; Xylenes - poisoning

Occupational exposure to (benzene, toluene and xylene, BTX is common in the Chinese workplace. Chronic occupational exposure to benzene is associated with an increased risk of hematological malignancies such as acute myeloid leukemia (AML), but the underlying mechanisms are still unclear. This study...