A Critical Role of the mTOR/eIF2α Pathway in Hypoxia-Induced Pulmonary Hypertension

• Published in: PloS one Vol. 10; no. 6; p. e0130806
• Main Authors: Wang, Ai-ping, Li, Xiao-hui, Yang, Yong-mei, Li, Wen-qun, Zhang, Wang, Hu, Chang-ping, Zhang, Zheng, Li, Yuan-jian
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.06.2015; Public Library of Science (PLoS)
• Subjects: Animals; Arteries; c-Myc protein; Cell cycle; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Cyclin-dependent kinases; Eukaryotic Initiation Factor-2 - metabolism; Hemodynamics - drug effects; Hypertension; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - metabolism; Hypertension, Pulmonary - pathology; Hypertension, Pulmonary - physiopathology; Hypoxia; Hypoxia - complications; Hypoxia - pathology; Hypoxia - physiopathology; Inhibitors; Initiation factor eIF-2α; Kinases; Male; Muscles; Myc protein; Myocytes, Smooth Muscle - metabolism; Proto-Oncogene Proteins c-myc - metabolism; Pulmonary artery; Pulmonary Artery - pathology; Rapamycin; Rats; Rats, Sprague-Dawley; RNA, Small Interfering - metabolism; Rodents; Signal Transduction - drug effects; Signaling; siRNA; Sirolimus - pharmacology; Smooth muscle; TOR protein; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; Translation; Up-Regulation - drug effects; Vascular Remodeling - drug effects; Veins & arteries; China

Enhanced proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is a key pathological component of vascular remodeling in hypoxia-induced pulmonary hypertension (HPH). Mammalian targeting of rapamycin (mTOR) signaling has been shown to play a role in protein translation and partic...