Association of Single Nucleotide Polymorphisms in the Lens Epithelium-Derived Growth Factor (LEDGF/p75) with HIV-1 Infection Outcomes in Brazilian HIV-1+ Individuals

• Published in: PloS one Vol. 9; no. 7; p. e101780
• Main Authors: Passaes, Caroline Pereira Bittencourt, Cardoso, Cynthia Chester, Caetano, Diogo Gama, Teixeira, Sylvia Lopes Maia, Guimarães, Monick Lindenmeyer, Campos, Dayse Pereira, Veloso, Valdilea Gonçalves, Babic, Dunja Z., Stevenson, Mario, Moraes, Milton Ozório, Morgado, Mariza Gonçalves
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.07.2014; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Alleles; Biology and Life Sciences; Brazil - epidemiology; Cohort Studies; Disease Progression; Drug therapy; Epithelium; Female; Gene expression; Genomes; Growth factors; Haplotypes; HIV; HIV Infections - epidemiology; HIV Infections - genetics; HIV Infections - pathology; HIV-1 - isolation & purification; HIV-1 - physiology; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Integrase; Intercellular Signaling Peptides and Proteins - genetics; Leukocytes (mononuclear); Linkage disequilibrium; Male; Medicine; Medicine and Health Sciences; Middle Aged; Patients; Peripheral blood mononuclear cells; Phenotypes; Polymorphism, Single Nucleotide; Regression analysis; Regression models; Single-nucleotide polymorphism; Virus Integration; Young Adult; Brazil; United States > US; Rio de Janeiro Brazil

The lens epithelium-derived growth factor p75 (LEDGF/p75), coded by the PSIP1 gene, is an important host co-factor that interacts with HIV-1 integrase to target integration of viral cDNA into active genes. The aim of this study was to investigate the association of SNPs in the PSIP1 gene with diseas...