Functional characterization of Plasmodium berghei PSOP25 during ookinete development and as a malaria transmission-blocking vaccine candidate

• Published in: Parasites & vectors Vol. 10; no. 1; p. 8
• Main Authors: Zheng, Wenqi, Liu, Fei, He, Yiwen, Liu, Qingyang, Humphreys, Gregory B., Tsuboi, Takafumi, Fan, Qi, Luo, Enjie, Cao, Yaming, Cui, Liwang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 05.01.2017
• Subjects: Animals; Antibodies, Protozoan - immunology; antibody formation; Antigens, Protozoan - genetics; Antigens, Protozoan - immunology; Culicidae; Disease Models, Animal; Disease Transmission, Infectious - prevention & control; fluorescent antibody technique; Gene Deletion; genes; genetic engineering; humans; Immunization, Passive; malaria; Malaria - prevention & control; Malaria Vaccines - immunology; Mice; midgut; monoclonal antibodies; oocysts; ookinetes; Plasmodium berghei; Plasmodium berghei - genetics; Plasmodium berghei - growth & development; Plasmodium berghei - immunology; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Protozoan Proteins - metabolism; recombinant proteins; surface proteins; vaccines; Western blotting; Plasmodium berghei; Ookinete; PSOP25; Transmission-blocking vaccine

Plasmodium ookinete surface proteins as post-fertilization target antigens are potential malaria transmission-blocking vaccine (TBV) candidates. Putative secreted ookinete protein 25 (PSOP25) is a highly conserved ookinete surface protein, and has been shown to be a promising novel TBV target. Here,...