Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

• Published in: PloS one Vol. 9; no. 10; p. e110024
• Main Authors: Wang, Yue, Jin, Shijie, Sonobe, Yoshifumi, Cheng, Yi, Horiuchi, Hiroshi, Parajuli, Bijay, Kawanokuchi, Jun, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.10.2014; Public Library of Science (PLoS)
• Subjects: Amyotrophic lateral sclerosis; Animals; Astrocytes; Astrocytes - metabolism; Biology and Life Sciences; Blood; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Brain research; CCL20 protein; Cell culture; Cell division; Cell Line; Cell migration; Central nervous system; Chemokines; Chemokines - genetics; Chemokines - metabolism; Conditioning; Cytokines; Disease; Disruption; Down-Regulation; Endothelial cells; Environmental health; Gene Expression; Hedgehog protein; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Homeostasis; IL-1β; Inflammation; Integrity; Interleukin-1beta - physiology; Interleukins; Medical research; Medicine; Medicine and Health Sciences; Membrane permeability; Mice; Microglia; Monocyte chemoattractant protein 1; Multiple sclerosis; Nervous system; Neurological diseases; Paracrine Communication; Parkinson's disease; Pericytes; Permeability; Proteins; R&D; Research & development; Therapeutic applications; Tight Junctions - metabolism; United States > US; Japan

The blood-brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglia...