Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes - Wang, Yue; Jin, Shijie; Sonobe, Yoshifumi; Cheng, Yi; Horiuchi, Hiroshi; Parajuli, Bijay; Kawanokuchi, Jun; Mizuno, Tetsuya; Takeuchi, Hideyuki; Suzumura, Akio (PloS one, 2014)
Keywords: Amyotrophic lateral sclerosis; Animals; Astrocytes; Astrocytes - metabolism; Biology and Life Sciences; Blood; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Brain research; CCL20 protein; Cell culture; Cell division; Cell Line; Cell migration; Central nervous system; Chemokines; Chemokines - genetics; Chemokines - metabolism; Conditioning; Cytokines; Disease; Disruption; Down-Regulation; Endothelial cells; Environmental health; Gene Expression; Hedgehog protein; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Homeostasis; IL-1β; Inflammation; Integrity; Interleukin-1beta - physiology; Interleukins; Medical research; Medicine; Medicine and Health Sciences; Membrane permeability; Mice; Microglia; Monocyte chemoattractant protein 1; Multiple sclerosis; Nervous system; Neurological diseases; Paracrine Communication; Parkinson's disease; Pericytes; Permeability; Proteins; R&D; Research & development; Therapeutic applications; Tight Junctions - metabolism; United States--US; Japan